DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Setdb2

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_001307649.1	Gene:	Setdb2 / 239122	MGIID:	2685139	Length:	697	Species:	Mus musculus

Alignment Length:	670	Identity:	133/670 - (19%)
Similarity:	225/670 - (33%)	Gaps:	211/670 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1108 EEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRK-----NLEAGTQPKKEKPVQ--- 1164
            :..|.|...|:.|:...|:.    ..|.:....|.|....:|     ..:|....|||.|:.
Mouse    70 DHTPVTQSEQENKSSAVPSA----SCDNSCPKGCTIPSPGKKVFLPVKNKADNLVKKEAPLHISF 130

  Fly  1165 -------------PVTVE-EIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYA 1215
                         |:::: |.|.::|:       ....:|..:....|    :|..|    .:|.
Mouse   131 HRHICSRTCLMETPLSLKGENPLQLPI-------RCHFQRRHAKTNSH----SSALH----VNYK 180

  Fly  1216 S-CSESSEDKASTTSLRKLSKV-------KKTYLVAGLFS---------NHYKQSLMPPPAKVNK 1263
            : |..         :||.:.:|       :..:|....||         ||.||:.:.....::.
Mouse   181 TPCGR---------NLRNMEEVFHYLLETECNFLFTDNFSFNTYVQLTRNHPKQNEVVSDVDISN 236

  Fly  1264 KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPT---RNVVPSWNYRKIRT 1325
              |:|.    .|:    |:|      .|:|            |||||.   ||.|....|....:
Mouse   237 --GVES----VSI----PFC------NEID------------NSKLPRFKYRNTVWPRIYHLNFS 273

  Fly  1326 NVYAESVRPNLAGFDHPTCNC-----KNQGEKSCL----DNC-------LNRMVYT---ECSPSN 1371
            |::::|...:....|...|.|     ||  .|:|.    ..|       |.|::.|   ||: ..
Mouse   274 NMFSDSCDCSEGCIDIKKCACLQLTAKN--AKACPLSSDGECAGYKYKRLQRLIPTGIYECN-LL 335

  Fly  1372 CPAGEK-CRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEY--------------VG 1421
            |...:: |:|:.|| |.|...::.|.:..||||||....|.|||::..|              :|
Mouse   336 CKCNKQMCQNRVIQ-HGVRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLRRATPEKTNIG 399

  Fly  1422 E-------VVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDC--RFVNHSCEPNCEMQ 1477
            |       :|.....|:|...:..:|...:|         |..: ..||  :......||..||.
Mouse   400 ENGREQQHIVKNSFSKKRKLEVVCSDCDAHC---------DSPK-AEDCPPKLSGDLKEPAVEMN 454

  Fly  1478 KWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAV 1542
            ..:::....     ...|...:..|..:::|..|              .|.:...|
Mouse   455 HRNISRTQH-----HSVIRRTKSKTTVFHYSEKN--------------MGFVCSDS--------- 491

  Fly  1543 EAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKKLVRQFNTFLV---- 1603
             |.|     ..:||.:..|:......|:|.:|:||       .|..:.|...:.:.:...:
Mouse   492 -AAP-----EDKNGFKPAQEHVNSEARRAHEDLSS-------NPAGDSEDTQLTESDVIDITASR 543

  Fly  1604 RNFEKIRRCKAKRASDAAATASSPALGTTNGDIPGRRPSTPSSPSLAAQISALCSPRNIKTRGLT 1668
            .:.....|||.....|...|....       ::||:: |....|:.:....|||.......|
Mouse   544 EDSAPAYRCKHATIVDRKDTKQVL-------EVPGKK-SQEEEPAASQSQQALCDEELPSER--- 597

  Fly  1669 QAVHDPELEKMAKMAVVLRD 1688
            ..:....|.:::|.::.|.|
Mouse   598 TKIPSASLMQLSKESLFLLD 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	19/67 (28%)
		SET	1392..1512	CDD:214614	29/142 (20%)
		Bromo_ASH1	1680..1787	CDD:99955	3/9 (33%)
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Setdb2	NP_001307649.1	HMT_MBD	152..212	CDD:238689	13/83 (16%)
		Pre-SET	234..346	CDD:282838	33/142 (23%)
		SET	354..>395	CDD:214614	12/40 (30%)
		SET	<612..674	CDD:214614	2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930