DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ash1 and Dido1

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_780760.2 Gene:Dido1 / 23856 MGIID:1344352 Length:2256 Species:Mus musculus


Alignment Length:1509 Identity:291/1509 - (19%)
Similarity:485/1509 - (32%) Gaps:529/1509 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VLETQRAQESGSENEETDS-----------------ITDQSSQSKSIKSATQFSVQRSDTDGLRM 60
            :|:.| .:.:||..:|.||                 :..:|.:.:.||.    .::::.....:.
Mouse   318 ILQVQ-DETNGSATDEQDSGCRSVGADGTDCTSIGTVEQKSGEDQGIKG----RIEKAANPSGKK 377

  Fly    61 RISAIRPTLGVVATKKPPKSRKMSTQDTESGCSE--------AKNRAVSKKVKVKRKKLASSSGI 117
            ::...:|   ||.....||.       ...|||.        ..|..:.|......:.|  |||.
Mouse   378 KLKIFQP---VVEAPGAPKC-------IGPGCSSVAQPDSVYCSNDCILKHAAATMRFL--SSGK 430

  Fly   118 SKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNEL 182
            .:..|..:..|::...||      ||                        |.::.:||.      
Mouse   431 EQKTKPKEKVKTKPEKFS------LP------------------------KCSVQVGIK------ 459

  Fly   183 PNLVQAAIKRVESDTEDTTV---------EGSFRKAAKDKNLPQYQS-----TLLQDFMEKTQML 233
               :.:..||:.|:..:..|         |.|.::||.:.:.|.:.|     .:..:..||...|
Mouse   460 ---ISSVHKRLASEKRENPVKKVMLASRSETSGKEAACESSTPSWASDHNYNAVKPEKPEKPTAL 521

  Fly   234 GQTVNAKLAEEKVAKAKEETLVQTAVPRK---------RRGRPKKVVPTVPAP----GNSGPAIN 285
            ..|:.:|..::. .:.::.|:....:|:|         |:..|:.:||....|    ..:.|||.
Mouse   522 SPTLLSKSMKDD-RRVEDRTMAAVTIPKKALPSASLVGRQTSPRNLVPKKLPPYSNMAGAKPAIK 585

  Fly   286 E--SADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYL----DKRMYATERV 344
            :  |...|.|     .:...||..:...:|...|..|:.::||.....|.:    .|.|.|....
Mouse   586 KLPSGFKGTI-----PKRPWPSATLSGTSARQAGPTPMTAASKKLPGSAAVVGVTRKPMSANVPA 645

  Fly   345 LYP-------------PPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAAS 396
            ..|             .|.|:.|||.::     |.||     .||:.::.:....:....||   
Mouse   646 ASPAPGRLGPVSPAPSQPNSQIRQNIRR-----SLKE-----ILWKRVNDSDDLIMTENEVG--- 697

  Fly   397 GTGASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCG 461
                      |:                  :.|.....:.......:||.:|             
Mouse   698 ----------KI------------------ALHIEKEMFNLFQVTDNRYKSK------------- 721

  Fly   462 YRS------DCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISK 520
            |||      |.|..|.....:|.:...:.|::...::.|                |:|.:.:..|
Mouse   722 YRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELV----------------SKELSMWTEK 770

  Fly   521 PSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKS 585
            |: ||: ..|.:|...|..:..|..:          |.||         .:::|..|.|..:.:|
Mouse   771 PT-KSV-IESRTKLLNESKKNTTKPE----------TIPD---------MEDSPPVSDSEEQQES 814

  Fly   586 RRS----SAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDR 646
            .|:    |||.:...:.|.:.....:||...|..|                       |:|...:
Mouse   815 VRAAPEKSAAPLLDVFSSMLKDTTSQHRAHLFDLN-----------------------CKICTGQ 856

  Fly   647 LTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLS 711
            :..|..:                |:|.:|       ..|..||  |...|.|..|.|        
Mouse   857 VPSSEDE----------------PAPKKQ-------KLSASSK--KEDFKPRHDSSP-------- 888

  Fly   712 ASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNA 776
              .:..||.:.....:|...:......:|:|    .|..:::.:..:||:..|...:.  |.|:.
Mouse   889 --PNAVPNTADEGIADTLPENASEPDPESTS----SLNQERKCFPESPGDSHPEPSSL--GGLSP 945

  Fly   777 EAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNS 841
            .  :|:..:...|..|.|     .|..::||                :||....:.:...:||:.
Mouse   946 S--SASGGSGVVTTVTMS-----GRDPRTAL----------------SGSCTVTASMAAHLDNSQ 987

  Fly   842 ISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFE--PSVELEIQIP 904
            .|..||..|.|:...::..:    :...|.|::.|...|..|    |.|.:.|  ...|.:..:.
Mouse   988 ASETKLDMIKPALTSAVVPK----SILAKPSSSPDPRYLSVP----PSPSISESRSPPEGDTTLF 1044

  Fly   905 LSKLN---------ESV---ITKAEVESPLLSALD-IKEDTKKEVGQRVVETLLHKTGGNLLLKR 956
            ||:||         :||   :|||   .|:...|| :.||         :...:| .||.:..| 
Mouse  1045 LSRLNTIWKGFINMQSVAKFVTKA---YPVSGCLDYLSED---------LPDTIH-IGGRIAPK- 1095

  Fly   957 KRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSS---------NNV 1012
                   |.:..|.:.|..||.|   ..:|..| |..:.::....||....||         ||.
Mouse  1096 -------TVWDYVGKLKSSVSKE---LCLIRFH-PATEEEEVAYISLYSYFSSRGRFGVVANNNR 1149

  Fly  1013 NVQ-------AAPNP------PLD-----------------CERVPQAGEARETFVARTNQKAPR 1047
            :|:       :|.:|      |.:                 |::|.:...|.|  :.:|::|..|
Mouse  1150 HVKDLYLIPLSAKDPVPSKLLPFEGPGLESPRPNIILGLVICQKVKRPSSAGE--LDKTDEKRTR 1212

  Fly  1048 LSVVALERLQRPQTPARGRPRGRKP------------KNREQAEAAPQPPPKSEPEI-------- 1092
            |....||....|:..| ..|..:||            .:.....:.|.|||..||.:        
Mouse  1213 LQQEELETSVYPKVTA-ALPSEKKPPKYSVHSIDTAATSTTPPGSPPPPPPLPEPPVLKILSSLK 1276

  Fly  1093 --------RPAKKRGRQPKQPVLEEPPPTPPPQQ--------KKNKMEPNIRLPDG--IDPNTNF 1139
                    .|..........||......|..|.:        ||...||:.:...|  :.|:.:.
Mouse  1277 PGSTSTVTAPTTAAITTTASPVTAATSKTASPLEHILQTLFGKKKSFEPSGKESVGSTLSPHQDS 1341

  Fly  1140 SCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPAS 1204
            ..|           |.......|:....|::.      .|...|...|.:..|..|  :||   .
Mouse  1342 KAK-----------GEDTMSAAPLLDPIVQQF------GQFSKDKALEEEEEDDRP--YDP---E 1384

  Fly  1205 ESHNPG------------PQDYASCSESSE------DKASTTSL------------RKLSKVKKT 1239
            |.:||.            |.|..|.||::|      |....|.|            |...||..|
Mouse  1385 EEYNPDRAFHTLLAEPGRPHDVQSVSETAEREEVAYDPEDETILEEAKVTIDDLPNRMCMKVSAT 1449

  Fly  1240 YLVAGLFSNHYKQSLMPPP---AKVNK-----KPGLEEQ----------VGPA--------SLLP 1278
            ...|...::....||:...   .::||     |..||||          ||.:        :|:.
Mouse  1450 ERPADFTTDASSASLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMS 1514

  Fly  1279 PPPYCEKYLRRTEM 1292
            |||  :..|.:||:
Mouse  1515 PPP--KSSLGKTEL 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795
SET 1392..1512 CDD:214614
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Dido1NP_780760.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..256
TNG2 <157..299 CDD:227367
Nuclear localization signal. /evidence=ECO:0000255 162..170
Nuclear localization signal. /evidence=ECO:0000255 182..190
PHD_DIDO1_like 263..316 CDD:277109
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..535 11/54 (20%)
PHA03247 <483..663 CDD:223021 37/185 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..624 6/25 (24%)
PRK14954 <600..>665 CDD:184918 13/64 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 641..668 4/26 (15%)
TFS2M 669..770 CDD:128786 25/170 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 778..822 12/62 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..970 30/177 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1039 8/31 (26%)
SPOC 1045..1190 CDD:369497 37/169 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1197..1218 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1288 7/42 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1320..1347 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1362..1421 16/69 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1509..1609 7/20 (35%)
PHA03247 <1571..2083 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1630..2256
SF-CC1 2142..>2180 CDD:273721
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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