Protein Alignment ash1 and Setd2

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_036010808.1
• Gene: Setd2 / 235626
• MGIID: 1918177
• Length: 2551
• Species: Mus musculus
• Alignment Length: 2301
• Identity: 479/2301 - (20%)
• Similarity: 764/2301 - (33%)
• Gaps: 778/2301 - (33%)

  Fly    77 PPK-----SRKMSTQDTES---GCSEAKNRAVSKKVKVKR------------KKLASSSGISKSD 121
            |||     ..:..|.|..|   |..|.:|....|:.|::.            |.:|||..:.|..
Mouse    10 PPKMGDFYDPEHPTPDMFSWLNGSREEENETYHKQAKIENVQKTGFIKGPVFKGVASSRFLPKGT 74

  Fly   122 K----VSKSKKSQIS-AFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNE 181
            |    :.:..:.::| :||      ...|..|.|    .|:|:....||          .|.::.
Mouse    75 KTKVNLEEQGRQKVSFSFS------FTKKTLQNR----FLTALSNEKQS----------DSPNSP 119

  Fly   182 LPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKV 246
            .|.|...:..:|:.|..||.       .|.:::.|......|.....|..:|..|...:||....
Mouse   120 APPLQVDSNPKVKMDAGDTF-------PATEESSPPKSRVELGRIHFKKHLLHVTSRPQLAASTT 177

  Fly   247 AKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKMQNE 311
            |          |.|         :.||...|.....::.:|..|.........|:::|||..|.
Mouse   178 A----------ASP---------LPPTTQLPAVLAESMIDSPPSSPPPPPPPPQASSPSPPAQI- 222

  Fly   312 NAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPP--------PRSKRRQ-----------NN 357
                  |.|:|....|            ||..:..||        .|:::..           :.
Mouse   223 ------SEPVALPQPP------------ATALMTSPPGPLPGDVAVRAQKESPVKSGPEVLEVDT 269

  Fly   358 KKTACSSSNKEEL------QLDPLWREID--VNKKFRLRSMSVGAASGTGASTTICSKVLAAKS- 413
            |:...|:|.:|..      |.|.|.::.|  :.|:..:         ..|:..::.||..::|.
Mouse   270 KQDIVSNSLEEHTVQTLKEQADHLLQKEDSHIGKEEEV---------SDGSKISLSSKKASSKKK 325

  Fly   414 ---------GYVSDYGSVRHQRSSHNHN-----------SGYKSDASCKS--------------- 443
                     |..||..|||...|..:|:           ...||.|..||
Mouse   326 SSQFEGTFLGSESDEDSVRTSSSQRSHDLKSSTSIDKERDFKKSSAPSKSEDLGKSSRSKTERDD 390

  Fly   444 ------------RYSTKSCMS----RRSRAKSCGYRSDCKESGKSGLRMRRKRRA---------- 482
                        ||.:..|.|    ||||::|   |||  .:.::.|...|..|:
Mouse   391 RYCSYSKLERDTRYVSSRCRSERDRRRSRSRS---RSD--RASRTSLSYSRSERSHYYDSERRYH 450

  Fly   483 --------SMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEY-------ISKPSLKSLPTTSAS 532
                    :...:...|:...             :||:..:||       .|..|.:.|.|:|:.
Mouse   451 RSSPYRERTRYSRPYTDNRAR-------------ESSDSEDEYKKTYPRRTSAHSYRDLRTSSSY 502

  Fly   533 KKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPS--KSSC----KIKSRRSSAA 591
            .|:....:..|:.....|.|        .:.||:..:.|.|....  |..|    ::..||.|:.
Mouse   503 SKFDRDCKTETSYLEMERRG--------KYTSKLERESKRTSEHETIKRCCSPPNELGFRRGSSY 559

  Fly   592 S----MCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEI-----EIITSTFNSRCRIQDDRL 647
            |    ..|.|.|.:|        ||.|.|.... :|...||:     :..:.:..:.|
Mouse   560 SKHDNSTSRYKSALS--------KSISKNDKFK-NSFCCTELNEENKQSHSFSLQTPC------- 608

  Fly   648 TGSSGKEKLLADANKL--QATLAAPSPAQQLTLNGGGPA------STLSKPL------KRGLKKR 698
              |.|.|  |...||:  :....:|:|:.||   ...|.      |.:.||.      :..:|:.
Mouse   609 --SKGSE--LRTINKISEREKTGSPTPSNQL---NDSPTFKKLDESPVLKPEFIGHDGRESIKEL 666

  Fly   699 KLS----EPLVDFAMLSASASGTP-------------------------NGSG----------SS 724
            :||    :.|.:|..:..:.:|:|                         .||.          ||
Mouse   667 ELSKVKNDQLRNFCSIELNVNGSPETEADVATFCTSKTDAISMTSDDSVTGSEVSPLIKACMLSS 731

  Fly   725 NG-------------NTKRRHKKSQS-----NDSSSPDDHKL-----------------PLKKRH 754
            ||             :|.|:|..|:|     ....||...||                 |:.|||
Mouse   732 NGFQNVGRCRERDSDDTCRQHNTSKSPFREMEPLLSPHHDKLMSLPVKTIDYPKTLIKEPVDKRH 796

  Fly   755 ---------YLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSAL--- 807
                     ...:|.|.|.||        |||..|       .|.|:.|....:..| |:.:
Mouse   797 SCCKTKDSDIYCSPNENPEAE--------NAEPSA-------MTISSHSFVNVHLES-KTVICDN 845

  Fly   808 -TPKKRH---LLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAK 868
             .|..||   ..::.....|:.||||::..          .|....|..|.:.||:....|...:
Mouse   846 REPTDRHSENTCDEYKQSIGSTSSASHNHF----------DGLYEPIGSSGISSLQSPPSGIRCE 900

  Fly   869 QKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIK---- 929
            :..|...|.|:                          ||.....:..|..|:.:.|||...
Mouse   901 ENTSPTLDAVE--------------------------SKKGIDFLKYARKETDVGSALPDSGKGF 939

  Fly   930 --EDTKKEV--GQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQ-TTAVIDEH 989
              |:....|  ||.:.|.   :..||.:|..:|      |.|.:     .:..||: .|.:.|:.
Mouse   940 SWENRHNNVLSGQSLQEA---QEEGNSILHERR------GRPEI-----PLDEEQRGHTHISDDS 990

  Fly   990 EPEFDPD--------DEPLQSLRETRSSNNVNV-----------QAAPNPPLDCERVPQAGEARE 1035
            |..|..|        |....:|:...|.|...:           .|:.:...|.|..    |:.:
Mouse   991 EVVFPYDLNLTMEDSDGITYTLKCDSSGNAPEIVSTVHEDYSGSSASSSDESDSEDT----ESDD 1051

  Fly  1036 TFVARTNQKA----PRLSVVALERLQR------------------------------------PQ 1060
            :.:.|...::    |:.|.:.:|....                                    .|
Mouse  1052 SSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYKHYSDRWEDGLETRRHAYEEEYESKGCSQ 1116

  Fly  1061 TPA----RGRPR---------GRKPKNR---------EQAEAAPQPPPKSE------PEIRPAKK 1097
            |..    :|..|         |||..|.         :..::..|...:|:      ||.....|
Mouse  1117 TEKYFLHKGTERSAESCYSQFGRKADNHLPDIAHAQSDGVDSTSQTDSRSDHLGHLNPEDTLRAK 1181

  Fly  1098 RGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGI---DPNTNFSCKIRLKRRKNLEAGTQ--- 1156
            ..|..:.||..:.....|.:.::..:..|  .||..   ....:||....:.|...|.:..:
Mouse  1182 TSRPQELPVYSDDFEDLPNKSRQQMIFSN--RPDSSRLGKTELSFSSSCDISRMDGLHSSEELRN 1244

  Fly  1157 -----PKKEKPV----QP-------------VTVEEI--------------------PPEIPVSQ 1179
                 .::|:|.    ||             .:.|..                    ||...::.
Mouse  1245 LGWDFSQQERPTTTYQQPDSSYGTCGTHKYQQSTEHYGGTHNYWQGNGYWDPRSAGRPPGTGLAY 1309

  Fly  1180 EEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAG 1244
            :.|..:......|....|......|.||...|.:.....:  :||.|..:....|...|..||..
Mouse  1310 DRIQGQVPDSLTDDREEEEHWDQRSGSHFSSPSNKFFFHQ--KDKGSVQAPEISSNSIKDALVMN 1372

  Fly  1245 L---FSNHYKQSLMP---PPAK----------------VNKKPGLEEQVGPASLLPPPPYCEKYL 1287
            .   ||.:::::.:.   ||.|                ..||..:|.:.|.:|:   |.:.|...
Mouse  1373 ERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGELQARKKVRVEMEQGESSV---PQHSELMG 1434

  Fly  1288 RRTEM-DFELPYDIWWAYTN-SKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFD--HPTCNC-- 1346
            ....| ||..| ..|..:.. .|:|.       .:..|..|||....:.|.:..|  ...|.|
Mouse  1435 PSCAMDDFRDP-QRWKEFAKLGKMPC-------YFDLIEENVYLTERKKNKSHRDIKRMQCECTP 1491

  Fly  1347 -----KNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQR--HAVAPGVERFMTADKGWGV 1404
                 :.|||.:|.::||||::..||| |.||.|:.|.|::.||  ||   .||..:|..||||:
Mouse  1492 LSKDERAQGEVACGEDCLNRLLMIECS-SRCPNGDYCSNRRFQRKQHA---DVEVILTEKKGWGL 1552

  Fly  1405 RTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLN-DTHHYCLHLDGGLVIDGQRMGSDCRFVNH 1468
            |....:...|::|||.|||:..||||.|:.....| :.|:|.:.|....:||..:.|:..||:||
Mouse  1553 RAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNH 1617

  Fly  1469 SCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGG-- 1531
            |||||||.|||:|||..|:..|..:.:..|.|||:||.|..:. .|.|.|.|.:..|||.:||
Mouse  1618 SCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYG-KEAQKCFCGSANCRGYLGGEN 1681

  Fly  1532 -----------KSQRVKPLPAVEAK-----PSGEGLSGRN-------------GRQRKQKAKKHA 1567
                       |.:|.:...:|:.:     .:|||||.:|             ..::|....|..
Mouse  1682 RVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLKLI 1746

  Fly  1568 QRQAGKDISSA-----------VAVAKLQPLSEKEKKLVRQFNTFLVRNFEKI------------ 1609
            |....:....:           :.:|:|....|..:||..:    :::..|.:
Mouse  1747 QNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEE----IIKTLEHLPIPTKNMLEESK 1807

  Fly  1610 ------RRCKAKRA-----------SDAAATASSPALGTTNGDIPGRRPSTPSSPSLAAQISALC 1657
                  |..:.|.|           |:..:.|.:| |.|.:   |..:|||.....
Mouse  1808 VLPIIQRWSQTKTAVPQLSEGDGYSSENTSRAHTP-LNTPD---PSAKPSTEMDTD--------- 1859

  Fly  1658 SPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMET---LKMSDLLTTVSSKKKKPIKTTLSG 1719
            :|:.:..|.|       ::.....|...:.|:.|.:|.   .:..|.|.||:.::.:.:::  ..
Mouse  1860 TPKKLIFRRL-------KIISENSMDSAVSDVTSELECKDGKEDLDQLETVTVEEDEELQS--QQ 1915

  Fly  1720 KLGSTAATSKVEFRSIQAQVEQGHYKTPQ-EFDDHMQQLFVEAKQQHG-----------DDEGKE 1772
            .|......||||   .:|.:|.....|.: |.|..     .|.|..:|           ..:.:|
Mouse  1916 LLPQQLCESKVE---SEATIEVSKLPTSEPEADTE-----TEPKDSNGTKLEETIAEETPSQDEE 1972

  Fly  1773 KALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKP-KEVL-----SSEEEPGKIAVKKSPGAKE 1831
            :.:..::....|:.....|.:.::.  ::.|.|:|. |||.     |..|:...:|.:....|..
Mouse  1973 EGVSDVESERSQEPPDKTVDISDLA--TKLLDSWKDLKEVYRIPKKSQTEKESTVAERGRDAAAF 2035

  Fly  1832 RDSPIVPLKVTPP--PLLPIEASPDE 1855
            ||.       |.|  |....|..||:
Mouse  2036 RDQ-------TAPKTPNRSRERDPDK 2054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	62/400 (16%)
		AWS	1340..1388	CDD:197795	23/58 (40%)
		SET_ASH1L	1391..1531	CDD:380951	60/140 (43%)
		Bromo_ASH1	1680..1787	CDD:99955	23/121 (19%)
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Setd2	XP_036010808.1	AWS	1483..1537	CDD:197795	21/54 (39%)
		SET_SETD2	1537..1678	CDD:380949	62/144 (43%)
		WW	2378..2407	CDD:459800
		SRI	2454..2542	CDD:462404