DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Nsd3

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_001074738.1	Gene:	Nsd3 / 234135	MGIID:	2142581	Length:	1446	Species:	Mus musculus

Alignment Length:	1706	Identity:	353/1706 - (20%)
Similarity:	566/1706 - (33%)	Gaps:	529/1706 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 PNLVQAAIKRVES--DTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEK 245
            |.|:.:|..|.|.  |.....||        |.....:::||.|.|                  :
Mouse    20 PQLIDSANIRQEDAFDNHSDIVE--------DGGPTPFEATLQQGF------------------Q 58

  Fly   246 VAKAKEETLVQTAVPRKRRGRPKKV----VPTVPAPGNSGPAINESADS-GVISTTSTTQ----- 300
            .....|:      :|....|.|..:    ..|...|.|..|  |.||:. |.:...|.|.
Mouse    59 YPPTTED------LPPLTNGYPPSISLYETQTKYPPYNQYP--NGSANGFGAVRNFSPTDYYHSE 115

  Fly   301 --STTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACS 363
              :|.|...::..:......||......|                   |||...:....|||
Mouse   116 IPNTRPHEILEKPSPPQPPPLPPPPPPPP-------------------PPPSVPQTVIPKKT--- 158

  Fly   364 SSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQRSS 428
              ...|::| .:.:.|...::.              ..:::|..:|       ::..:..|.:|.
Mouse   159 --GSPEIKL-KITKTIQNGREL--------------FESSLCGDLL-------NEVQASEHTKSK 199

  Fly   429 HNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLK------ 487
            |.                     ||:.:.|    :|:..||.:|     .:||:..:.|
Mouse   200 HE---------------------SRKEKRK----KSNRHESSRS-----EERRSHKIPKLEPEGQ 234

  Fly   488 -------SSADDTVEDQDILQLAGLSLGQSSEESNEYIS-KPSLKSLPTTSASKKYGEINRYVTT 544
                   .:|.:...::.:|:              |.|. :|.|.|:|||..|           |
Mouse   235 NRPNERVDTAPEKPREEPVLK--------------EAIPVQPILSSVPTTETS-----------T 274

  Fly   545 GQYFGRGG---SLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRR 606
            |..|..|.   |...|.|  :...|::...:....||.:                     :|..|
Mouse   275 GVKFQVGDLVWSKVGTYP--WWPCMVSSDPQLEVHSKIN---------------------TRGAR 316

  Fly   607 RHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRL---TGSSGKEKLLADANKLQAT-- 666
            .:..:.||:..                    .|..:.:.|:   .|....|:|||:|.| ||:
Mouse   317 EYHVQFFSNQP--------------------ERAWVHEKRVREYKGHEQYEELLAEAAK-QASNH 360

  Fly   667 -----LAAPSPAQQLTLNGGGPASTLSKPLKRGLKKR--KLSEPLVDFAMLSASASGTPNGSGSS 724
                 :..|.|.::......|.|.. .|.||...::|  :.:...:|.....||:....|.:..:
Mouse   361 SEKQKIRKPRPQRERAQWDIGIAHA-EKALKMTREERVEQYTFIYIDKQPEEASSQAKKNVTSKT 424

  Fly   725 NGNTKRRHKK------SQSN-----DSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEA 778
            .....||.:.      .|:|     .|.|..|.:...::||..|...|.||.::          |
Mouse   425 EVKKPRRPRSVLNSQPEQTNAGEVASSQSSTDLRRQSQRRHTSLEEEEPPPVKI----------A 479

  Fly   779 WAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPL----RIVVDN 839
            |..|||               .:|:.:::|..|..|..|..::         ||:    ::....
Mouse   480 WKTAAA---------------RKSLPASITMHKGSLDLQKCNM---------SPVVKIEQVFALQ 520

  Fly   840 NSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSA-AKDLVQLQSPA--GSYPPPGVFEPSVELEI 901
            |:...||.:|       ......:|...|.::|. .:|.:.:.||:  ...|......|......
Mouse   521 NATGDGKFID-------QFVYSTKGIGNKTEISVRGQDRLIISSPSQRSEKPAQSASSPEATSGS 578

  Fly   902 QIPLSKLNE--SVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLH---KTGGNLLLKRKRKKI 961
            ..|:.|..:  |:.|::|.|.   ||..:   .||::.:..|||...   |||    |::...:|
Mouse   579 AGPVEKKQQRRSIRTRSESEK---SAEVV---PKKKIKKEQVETAPQASLKTG----LQKGASEI 633

  Fly   962 NRTGFPTVRRKKRKVSVEQQTTAV---------------------IDEHEPEFDPDDEPLQSLRE 1005
            :.:..|..:|.:....||..:...                     :|......|.|....||:..
Mouse   634 SDSCKPLKKRSRASTDVETASCTYRDTSDSDSRGLSDGQVGFGKQVDSPSATADADASDAQSVDS 698

  Fly  1006 TRSSNNVNVQAAPNPPLDCER-----VPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARG 1065
            :.|...|...........||:     |...||....|....      |.:.|:
Mouse   699 SLSRRGVGTSKKDTVCQVCEKAGDCLVACEGECCRHFHVEC------LGLTAV------------ 745

  Fly  1066 RPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIR-L 1129
             |.|.  ...|:.|....|       ....|..|:..|:..:.        ...|...|..:| .
Mouse   746 -PEGH--FTCEECETGQHP-------CFSCKVSGKDVKRCSVS--------VCGKFYHEACVRKF 792

  Fly  1130 PDGIDPNTNFSCK----IRLKRRKNLEAGTQPKKEKPVQ-PVTVE-----EIPPEIPVSQEEIDA 1184
            |..|..:..|.|.    ......|::...::.:..:.:: ||...     .....:.||...:..
Mouse   793 PTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLRCPVAYHVGDACVAAGSVSVSSHILIC 857

  Fly  1185 EAEAKRLDS----------------IPTEH-DPLPASESHNPGPQDYASCSESSEDK-------- 1224
            ...:||...                |..:| ||:.:|.::    :.:...|||:..:
Mouse   858 SNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAY----KSHYLLSESNRAELMKLPMIP 918

  Fly  1225 ASTTSLRKLSKVKKTYLVAGLFSNHYKQSL---MPP------PAKVNKKPGLEEQV--------- 1271
            :|:.|.::..|..:........::.:.:.|   ||.      ..|..||...::.|
Mouse   919 SSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRW 983

  Fly  1272 GPASLLPP--PPYCEKYLRRTEMDFEL----PYDIWWAYTNSKLP-------------------- 1310
            .||.:..|  .|...:.|:....||.:    .:|.:|.:.....|
Mouse   984 WPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAEGQTSINKTFK 1048

  Fly  1311 ----------------------------TRNVVPSWNYRKIRTNVYAESVRPNLAGFDH-PTCNC 1346
                                        :|...|   |:.|:.|.....|:..:|.... |.|||
Mouse  1049 KALEEAAKRFQELKAQRESKEALEMERTSRKPPP---YKHIKANKVIGKVQVQVADLSEIPRCNC 1110

  Fly  1347 KNQGEKSC-LDN-CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLP 1409
            |...|..| |:: |||||...||.|..||||::|:||...:. :.|..|...|..:|||:|||..
Mouse  1111 KPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKR-LYPDAEVIKTERRGWGLRTKRS 1174

  Fly  1410 IAKGTYILEYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPN 1473
            |.||.::.|||||::.|:|.:.|:...:.|. |:.|.|.:....:||....|:..||:||||.||
Mouse  1175 IKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPN 1239

  Fly  1474 CEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQP-CRCNTPQCRGVIGGKSQRVK 1537
            ||.|||:|||..|:.|||...|..|.|||::||....  ..|:. |.|....|.|.:|     |:
Mouse  1240 CETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCL--GNGRTVCHCGADNCSGFLG-----VR 1297

  Fly  1538 P----LPAVEAKPSGEGLSGRNGRQRKQKAKK-HAQR--QAG----------KDISSAVAVAKL- 1584
            |    ..||:.|.....|..|  |:.|.:||. |...  |.|          ||...|..:..|
Mouse  1298 PKSACTSAVDEKTKNAKLKKR--RKVKAEAKPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLN 1360

  Fly  1585 --QPLSEKEK----------KLVRQFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGDIP 1637
              ||...|.:          .:...|..|...:|     |||........:|....|..::.|
Mouse  1361 LTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSF-----CKAHGKGALVPSALEGRLCCSSHD-- 1418

  Fly  1638 GRRPSTPSSPSLAAQI 1653
               |::|.||...::|
Mouse  1419 ---PASPVSPEYWSKI 1431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	23/50 (46%)
		SET	1392..1512	CDD:214614	53/120 (44%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Nsd3	NP_001074738.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..257		15/109 (14%)
		MSH6_like	277..393	CDD:99898	30/160 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..377		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..476		15/64 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..705		33/164 (20%)
		PHD_SF	713..755	CDD:304600	11/62 (18%)
		PHD2_NSD3	761..807	CDD:277122	11/60 (18%)
		PHD_SF	808..860	CDD:304600	5/51 (10%)
		PHD4_NSD3	927..962	CDD:277128	4/34 (12%)
		WHSC1_related	968..1061	CDD:99899	11/92 (12%)
		AWS	1104..1154	CDD:197795	23/50 (46%)
		SET	1155..1278	CDD:214614	54/124 (44%)
		PHD5_NSD3	1332..1374	CDD:277131	9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950