Protein Alignment ash1 and Kmt2c

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_006535745.1
• Gene: Kmt2c / 231051
• MGIID: 2444959
• Length: 4976
• Species: Mus musculus
• Alignment Length: 1935
• Identity: 347/1935 - (17%)
• Similarity: 583/1935 - (30%)
• Gaps: 758/1935 - (39%)

  Fly    38 QSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKP--------------PKSRKMSTQDT 88
            ||.|..:....:..|......::.:....|..|.|::..|              |.|.....::.
Mouse  3350 QSNSASAHLPLNPPRIQPPIAQLSLKTCTPAPGTVSSANPQNGPPPRVEFDDNNPFSESFQERER 3414

  Fly    89 ESGCSEA-------------KNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSED 140
            :....|.             :.||:.:::::::..|..      ::..:::..||:..:.||...
Mouse  3415 KERLREQQERQRVQLMQEVDRQRALQQRMEMEQHCLMG------AELANRTPVSQMPFYGSDRPC 3473

  Fly   141 DL-----PLK---VHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNEL--PNLVQAAIKRVES 195
            |.     ||:   .|||:...||....:|.....|.|......::...::  |:.|..:......
Mouse  3474 DFLQPPRPLQQSPQHQQQIGPVLQQQNVQQGSVNSPPNQTFMQTNEQRQVGPPSFVPDSPSASGG 3538

  Fly   196 DTEDTTVE--------GSFRKA---------------AKDKNLPQYQS---TLLQDFMEKTQMLG 234
            .....:|:        .||:::               ..:.|:|..|.   |..|::...:|.|.
Mouse  3539 SPNFHSVKPGHGNLPGSSFQQSPLRPPFTPILPGTSPVANSNVPCGQDPAVTQGQNYSGSSQSLI 3603

  Fly   235 QTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKK--------VVPTVPAPGNSGPAINESADSG 291
            |..:..:.|||              .:|:|.|.||        ..|:.|....:.|     ...|
Mouse  3604 QLYSDIIPEEK--------------GKKKRTRKKKKDDDAESGKAPSTPHSDCAAP-----LTPG 3649

  Fly   292 VISTTSTTQSTTPSPKMQNENAVPTGSLPI----ASSSKPKIDMAYLDKRMYATERVLYPPPRSK 352
            :..||||...::||...|.....|...:|:    .|:.:|.|:          :|..|   |.|:
Mouse  3650 LSETTSTPAVSSPSELPQQRQQEPVEPVPVPTPNVSAGQPCIE----------SENKL---PNSE 3701

  Fly   353 --RRQNNKKT---------ACSSSNK-EELQLD-----PLWREIDVNKKFRLRSMSVGAASGTGA 400
              :..:|::|         :..:.|| ||::|:     |...:..|.:|             ||
Mouse  3702 FIKETSNQQTHVNAEADKPSVETPNKTEEIKLEKAETQPSQEDTKVEEK-------------TG- 3752

  Fly   401 STTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSD 465
                 :|:....:|.||..     |..||...:.           :||.
Mouse  3753 -----NKIKDIVAGPVSSI-----QCPSHPVGTP-----------TTKG---------------- 3780

  Fly   466 CKESGKSGLR-MRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPS-LKSLPT 528
              ::|...|: :.:.::||.||....:.|           ||..:||.:..:.|.|.| .:.|.|
Mouse  3781 --DTGNELLKHLLKNKKASSLLTQKPEGT-----------LSSDESSTKDGKLIEKQSPAEGLQT 3832

  Fly   529 TSASKKYGEINRYVTTGQYFGRGGS-LSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAAS 592
            ..|..:.|           ||.|.| |..|:..:...|..::|.:... .|::.:.|.|:.....
Mouse  3833 LGAQMQGG-----------FGGGNSQLPKTDGASENKKQRSKRTQRTG-EKAAPRSKKRKKDEEE 3885

  Fly   593 MCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLL 657
            ..:.|.|.          .||:|.|
Mouse  3886 KQAMYSSS----------DSFTHLK---------------------------------------- 3900

  Fly   658 ADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPL--VDFAMLSASASGTPNG 720
                            |||:|                   ..|.||:  |:||..      .|.|
Mouse  3901 ----------------QQLSL-------------------LPLMEPIIGVNFAHF------LPYG 3924

  Fly   721 SGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEV----------AFANGKLN 775
            ||..|..|:.......:......|.:...:.|::.|..| ..|||.:          ..|||...
Mouse  3925 SGQFNSGTRLLGTFGSAALEGVSDYYSQLIYKQNNLSNP-PTPPASLPPTPPPMACQKMANGFAT 3988

  Fly   776 AEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNN 840
            .|..|..|....|            ..|..||.||...|..:|.....|.:.|
Mouse  3989 TEELAGKAGVLVS------------HEVARALGPKPFQLPFRPQDDLLARAIA------------ 4029

  Fly   841 SISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPL 905
              .|.|.:|: |:||.:......            :.:::|...|....|..|.|
Mouse  4030 --QGPKTVDV-PASLPTPPHNNH------------EELRIQDHYGDRDTPDSFVP---------- 4069

  Fly   906 SKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKIN-------- 962
            |...|||:.....:.|.||.  :||:..:.|...::..|...:|.|...:|...|..
Mouse  4070 SSSPESVVGVEVNKYPDLSL--VKEEPPEPVPSPIIPILPSISGKNSESRRNDIKTEPGTLFFTS 4132

  Fly   963 ---------RTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAP 1018
                     |:|..:|.......:.|..::.|            .....|...|..|:..|..||
Mouse  4133 PFGSSPNGPRSGLISVAITLHPTAAENISSVV------------AAFSDLLHVRIPNSYEVSNAP 4185

  Fly  1019 N-PPL---DCERVPQAGEARETFVAR----TNQKAPRLSVVALERLQRPQT-------------- 1061
            : ||:   ...||..:.|.|:..:.|    .:...|||:  ...||::|..
Mouse  4186 DVPPMGLVSSHRVNPSLEYRQHLLLRGPPPGSANPPRLA--TSYRLKQPNVPFPPTSNGLSGYKD 4248

  Fly  1062 ----PARG---RP---------------------------------------------------- 1067
                ||.|   ||
Mouse  4249 SSHGPAEGASLRPQWCCHCKVVILGSGVRKSCKDLTFVNKGSRENTKRMEKDIVFCSNNCFILYS 4313

  Fly  1068 ---RGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQ---------PVLEE---PPPTPP-- 1115
               :.:...|:|...:.||.|.|     .|:|...:....         |..:|   ||.:||
Mouse  4314 SAAQAKNSDNKESLPSLPQSPMK-----EPSKAFHQYSNNISTLDVHCLPQFQEKVSPPASPPIS 4373

  Fly  1116 -------------PQQKK--NKMEPNIR-LPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQ 1164
                         |.:.|  .|::|.:| :|.|::     .|:...|:.:    |.:.||
Mouse  4374 FPPAFEAAKVESKPDELKVTVKLKPRLRTVPVGLE-----DCRPLNKKWR----GMKWKK----- 4424

  Fly  1165 PVTVEEIPPE---IPVSQEEIDAEAEAKRLDSIPTEHDPLP-----------ASESHNPGPQD-- 1213
             .::..:.|:   .|..::|||  ...|:|.:. .:.||:|           ..:....||..
Mouse  4425 -WSIHIVIPKGTFKPPCEDEID--EFLKKLGTC-LKPDPVPKDCRKCCFCHEEGDGLTDGPARLL 4485

  Fly  1214 --------YASC----SESSEDKAST-----TSLRKLSKVK-----KTYLVAGLF----SNHY-- 1250
                    :.:|    :|..|.:|..     .:||:..::|     ||...:|..    :|.|
Mouse  4486 NLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHF 4550

  Fly  1251 -------------KQSLMPPPAKVNKKPGLEEQ-------------------------------- 1270
                         |..|.|    ::|..|:.||
Mouse  4551 TCATKAQCMFFKDKTMLCP----MHKPKGIHEQQLSYFAVFRRVYVQRDEVRQIASIVQRGERDH 4611

  Fly  1271 ---VG--------------------PASLLP------------------------------PPPY 1282
               ||                    |.:|.|                              .|.:
Mouse  4612 TFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVF 4676

  Fly  1283 CEKYLRRTEMDFEL----PYDIW------WAYTNSKLPTRNVVPSWNYRK------IRTNVYAES 1331
            ..:.:.:...|..|    |.|:|      .|....|.....:.|:  |.|      :..:..|.
Mouse  4677 VIRIVEQGHEDLVLSDSSPKDVWDKILEPVACVRKKSEMLQLFPA--YLKGEDLFGLTVSAVAR- 4738

  Fly  1332 VRPNLAGFDHPTCNCKN----QGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAV---- 1388
            :..:|.|.:    .|:|    .|....::..|      ..:|:.|...|...:..::|..:
Mouse  4739 IAESLPGVE----ACENYTFRYGRNPLMELPL------AVNPTGCARSEPKMSAHVKRFVLRPHT 4793

  Fly  1389 -------------------APGVERFMTAD----------------------KGWGVRTKLPIAK 1412
                               ||..::|:.:.                      :|.|:.....|.|
Mouse  4794 LNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAARDIEK 4858

  Fly  1413 GTYILEYVGEVVTEKEFKQRMASIYLNDTHH-YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEM 1476
            .|.::||:|.:: ..|...|...:|.:.... |...:|...|||....|...|::||||.|||..
Mouse  4859 HTMVIEYIGTII-RNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVA 4922

  Fly  1477 QKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            :..:.....::::.:.|.|::||||.|||.|...:.....||.|....||
Mouse  4923 EVVTFERGHKIIISSNRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCR 4972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	81/518 (16%)
		AWS	1340..1388	CDD:197795	8/51 (16%)
		SET_ASH1L	1391..1531	CDD:380951	41/159 (26%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Kmt2c	XP_006535745.1	ePHD1_KMT2C	247..330	CDD:277166
		PHD1_KMT2C_like	343..388	CDD:276984
		PHD2_KMT2C	390..435	CDD:277069
		PHD3_KMT2C	466..517	CDD:276986
		PHD4_KMT2C	947..1003	CDD:277071
		PHD5_KMT2C_like	1004..1050	CDD:276988
		RanBP2-type Zn finger	1079..1101	CDD:275375
		PHD6_KMT2C	1081..1131	CDD:277073
		HMG-box_KMT2C	1640..1720	CDD:438835
		PHA03247	<1880..2370	CDD:223021
		PHA03247	<2146..2753	CDD:223021
		Myosin_tail_1	<3192..>3274	CDD:460256
		Atrophin-1	3289..>3601	CDD:460830	39/256 (15%)
		ePHD2_KMT2C	4467..4571	CDD:277167	17/107 (16%)
		FYRN	4616..4667	CDD:461787	4/50 (8%)
		FYRC	4673..4757	CDD:461788	16/90 (18%)
		SET_KMT2C_2D	4823..4975	CDD:380948	40/151 (26%)