DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ash1 and Kmt2c

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_006535745.1 Gene:Kmt2c / 231051 MGIID:2444959 Length:4976 Species:Mus musculus


Alignment Length:1935 Identity:347/1935 - (17%)
Similarity:583/1935 - (30%) Gaps:758/1935 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 QSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKP--------------PKSRKMSTQDT 88
            ||.|..:....:..|......::.:....|..|.|::..|              |.|.....::.
Mouse  3350 QSNSASAHLPLNPPRIQPPIAQLSLKTCTPAPGTVSSANPQNGPPPRVEFDDNNPFSESFQERER 3414

  Fly    89 ESGCSEA-------------KNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSED 140
            :....|.             :.||:.:::::::..|..      ::..:::..||:..:.||...
Mouse  3415 KERLREQQERQRVQLMQEVDRQRALQQRMEMEQHCLMG------AELANRTPVSQMPFYGSDRPC 3473

  Fly   141 DL-----PLK---VHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNEL--PNLVQAAIKRVES 195
            |.     ||:   .|||:...||....:|.....|.|......::...::  |:.|..:......
Mouse  3474 DFLQPPRPLQQSPQHQQQIGPVLQQQNVQQGSVNSPPNQTFMQTNEQRQVGPPSFVPDSPSASGG 3538

  Fly   196 DTEDTTVE--------GSFRKA---------------AKDKNLPQYQS---TLLQDFMEKTQMLG 234
            .....:|:        .||:::               ..:.|:|..|.   |..|::...:|.|.
Mouse  3539 SPNFHSVKPGHGNLPGSSFQQSPLRPPFTPILPGTSPVANSNVPCGQDPAVTQGQNYSGSSQSLI 3603

  Fly   235 QTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKK--------VVPTVPAPGNSGPAINESADSG 291
            |..:..:.|||              .:|:|.|.||        ..|:.|....:.|     ...|
Mouse  3604 QLYSDIIPEEK--------------GKKKRTRKKKKDDDAESGKAPSTPHSDCAAP-----LTPG 3649

  Fly   292 VISTTSTTQSTTPSPKMQNENAVPTGSLPI----ASSSKPKIDMAYLDKRMYATERVLYPPPRSK 352
            :..||||...::||...|.....|...:|:    .|:.:|.|:          :|..|   |.|:
Mouse  3650 LSETTSTPAVSSPSELPQQRQQEPVEPVPVPTPNVSAGQPCIE----------SENKL---PNSE 3701

  Fly   353 --RRQNNKKT---------ACSSSNK-EELQLD-----PLWREIDVNKKFRLRSMSVGAASGTGA 400
              :..:|::|         :..:.|| ||::|:     |...:..|.:|             || 
Mouse  3702 FIKETSNQQTHVNAEADKPSVETPNKTEEIKLEKAETQPSQEDTKVEEK-------------TG- 3752

  Fly   401 STTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSD 465
                 :|:....:|.||..     |..||...:.           :||.                
Mouse  3753 -----NKIKDIVAGPVSSI-----QCPSHPVGTP-----------TTKG---------------- 3780

  Fly   466 CKESGKSGLR-MRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPS-LKSLPT 528
              ::|...|: :.:.::||.||....:.|           ||..:||.:..:.|.|.| .:.|.|
Mouse  3781 --DTGNELLKHLLKNKKASSLLTQKPEGT-----------LSSDESSTKDGKLIEKQSPAEGLQT 3832

  Fly   529 TSASKKYGEINRYVTTGQYFGRGGS-LSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAAS 592
            ..|..:.|           ||.|.| |..|:..:...|..::|.:... .|::.:.|.|:.....
Mouse  3833 LGAQMQGG-----------FGGGNSQLPKTDGASENKKQRSKRTQRTG-EKAAPRSKKRKKDEEE 3885

  Fly   593 MCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLL 657
            ..:.|.|.          .||:|.|                                        
Mouse  3886 KQAMYSSS----------DSFTHLK---------------------------------------- 3900

  Fly   658 ADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPL--VDFAMLSASASGTPNG 720
                            |||:|                   ..|.||:  |:||..      .|.|
Mouse  3901 ----------------QQLSL-------------------LPLMEPIIGVNFAHF------LPYG 3924

  Fly   721 SGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEV----------AFANGKLN 775
            ||..|..|:.......:......|.:...:.|::.|..| ..|||.:          ..|||...
Mouse  3925 SGQFNSGTRLLGTFGSAALEGVSDYYSQLIYKQNNLSNP-PTPPASLPPTPPPMACQKMANGFAT 3988

  Fly   776 AEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNN 840
            .|..|..|....|            ..|..||.||...|..:|.....|.:.|            
Mouse  3989 TEELAGKAGVLVS------------HEVARALGPKPFQLPFRPQDDLLARAIA------------ 4029

  Fly   841 SISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPL 905
              .|.|.:|: |:||.:......            :.:::|...|....|..|.|          
Mouse  4030 --QGPKTVDV-PASLPTPPHNNH------------EELRIQDHYGDRDTPDSFVP---------- 4069

  Fly   906 SKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKIN-------- 962
            |...|||:.....:.|.||.  :||:..:.|...::..|...:|.|...:|...|..        
Mouse  4070 SSSPESVVGVEVNKYPDLSL--VKEEPPEPVPSPIIPILPSISGKNSESRRNDIKTEPGTLFFTS 4132

  Fly   963 ---------RTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAP 1018
                     |:|..:|.......:.|..::.|            .....|...|..|:..|..||
Mouse  4133 PFGSSPNGPRSGLISVAITLHPTAAENISSVV------------AAFSDLLHVRIPNSYEVSNAP 4185

  Fly  1019 N-PPL---DCERVPQAGEARETFVAR----TNQKAPRLSVVALERLQRPQT-------------- 1061
            : ||:   ...||..:.|.|:..:.|    .:...|||:  ...||::|..              
Mouse  4186 DVPPMGLVSSHRVNPSLEYRQHLLLRGPPPGSANPPRLA--TSYRLKQPNVPFPPTSNGLSGYKD 4248

  Fly  1062 ----PARG---RP---------------------------------------------------- 1067
                ||.|   ||                                                    
Mouse  4249 SSHGPAEGASLRPQWCCHCKVVILGSGVRKSCKDLTFVNKGSRENTKRMEKDIVFCSNNCFILYS 4313

  Fly  1068 ---RGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQ---------PVLEE---PPPTPP-- 1115
               :.:...|:|...:.||.|.|     .|:|...:....         |..:|   ||.:||  
Mouse  4314 SAAQAKNSDNKESLPSLPQSPMK-----EPSKAFHQYSNNISTLDVHCLPQFQEKVSPPASPPIS 4373

  Fly  1116 -------------PQQKK--NKMEPNIR-LPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQ 1164
                         |.:.|  .|::|.:| :|.|::     .|:...|:.:    |.:.||     
Mouse  4374 FPPAFEAAKVESKPDELKVTVKLKPRLRTVPVGLE-----DCRPLNKKWR----GMKWKK----- 4424

  Fly  1165 PVTVEEIPPE---IPVSQEEIDAEAEAKRLDSIPTEHDPLP-----------ASESHNPGPQD-- 1213
             .::..:.|:   .|..::|||  ...|:|.:. .:.||:|           ..:....||..  
Mouse  4425 -WSIHIVIPKGTFKPPCEDEID--EFLKKLGTC-LKPDPVPKDCRKCCFCHEEGDGLTDGPARLL 4485

  Fly  1214 --------YASC----SESSEDKAST-----TSLRKLSKVK-----KTYLVAGLF----SNHY-- 1250
                    :.:|    :|..|.:|..     .:||:..::|     ||...:|..    :|.|  
Mouse  4486 NLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHF 4550

  Fly  1251 -------------KQSLMPPPAKVNKKPGLEEQ-------------------------------- 1270
                         |..|.|    ::|..|:.||                                
Mouse  4551 TCATKAQCMFFKDKTMLCP----MHKPKGIHEQQLSYFAVFRRVYVQRDEVRQIASIVQRGERDH 4611

  Fly  1271 ---VG--------------------PASLLP------------------------------PPPY 1282
               ||                    |.:|.|                              .|.:
Mouse  4612 TFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVF 4676

  Fly  1283 CEKYLRRTEMDFEL----PYDIW------WAYTNSKLPTRNVVPSWNYRK------IRTNVYAES 1331
            ..:.:.:...|..|    |.|:|      .|....|.....:.|:  |.|      :..:..|. 
Mouse  4677 VIRIVEQGHEDLVLSDSSPKDVWDKILEPVACVRKKSEMLQLFPA--YLKGEDLFGLTVSAVAR- 4738

  Fly  1332 VRPNLAGFDHPTCNCKN----QGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAV---- 1388
            :..:|.|.:    .|:|    .|....::..|      ..:|:.|...|...:..::|..:    
Mouse  4739 IAESLPGVE----ACENYTFRYGRNPLMELPL------AVNPTGCARSEPKMSAHVKRFVLRPHT 4793

  Fly  1389 -------------------APGVERFMTAD----------------------KGWGVRTKLPIAK 1412
                               ||..::|:.:.                      :|.|:.....|.|
Mouse  4794 LNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAARDIEK 4858

  Fly  1413 GTYILEYVGEVVTEKEFKQRMASIYLNDTHH-YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEM 1476
            .|.::||:|.:: ..|...|...:|.:.... |...:|...|||....|...|::||||.|||..
Mouse  4859 HTMVIEYIGTII-RNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVA 4922

  Fly  1477 QKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            :..:.....::::.:.|.|::||||.|||.|...:.....||.|....||
Mouse  4923 EVVTFERGHKIIISSNRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCR 4972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 8/51 (16%)
SET 1392..1512 CDD:214614 36/142 (25%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Kmt2cXP_006535745.1 PHD2_KMT2C 390..435 CDD:277069
PHD3_KMT2C 466..517 CDD:276986
PHD4_KMT2C 947..1003 CDD:277071
PHD5_KMT2C_like 1004..1050 CDD:276988
RanBP2-type Zn finger 1079..1101 CDD:275375
PHD6_KMT2C 1081..1131 CDD:277073
HMG-box 1661..1712 CDD:381793
Tma16 1699..>1782 CDD:371407
PHA03247 <1880..2370 CDD:223021
PHA03247 <2146..2753 CDD:223021
PKK 3189..3275 CDD:372134
Atrophin-1 3288..>3590 CDD:367360 37/245 (15%)
ePHD2_KMT2C 4467..4571 CDD:277167 17/107 (16%)
FYRN 4616..4667 CDD:368685 4/50 (8%)
FYRC 4673..4757 CDD:368686 16/90 (18%)
SET_KMT2C_2D 4823..4975 CDD:380948 40/151 (26%)
ePHD1_KMT2C 247..330 CDD:277166
PHD1_KMT2C_like 343..388 CDD:276984
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848440
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.960

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