Protein Alignment ash1 and SETD1B

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001340274.1
• Gene: SETD1B / 23067
• HGNCID: 29187
• Length: 1966
• Species: Homo sapiens
• Alignment Length: 73
• Identity: 17/73 - (23%)
• Similarity: 26/73 - (35%)
• Gaps: 30/73 - (41%)

  Fly    14 IHPVDVIEGVCPLCLNERLLVVASLQRLRPPCPPSSYQTIPKTILQNSSRKKPIR------LFSF 72
            :.|.||:    .||:...:|:..:|             |:|..:.       |:|      ||..
Human   360 VDPFDVL----ILCVRVAVLIAVTL-------------TVPIVLF-------PVRRAIQQMLFQN 400

  Fly    73 FSFFELRH 80
            ..|..|||
Human   401 QEFSWLRH 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021
		AWS	1340..1388	CDD:197795
		SET_ASH1L	1391..1531	CDD:380951
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
SETD1B	NP_001340274.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068	68..98
		RRM_Set1B	101..193	CDD:409965
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..660		17/73 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..719
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	963..1462
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1501..1541
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1606
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1636..1668
		N-SET	1679..1821	CDD:463344
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	1745..1750
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1767..1800
		RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827	1798..1803
		SET_SETD1	1815..1962	CDD:380946