DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and SETD1B

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001340274.1 Gene:SETD1B / 23067 HGNCID:29187 Length:1966 Species:Homo sapiens


Alignment Length:1272 Identity:241/1272 - (18%)
Similarity:407/1272 - (31%) Gaps:433/1272 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   491 DDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLS 555
            |:..:.::.:..|.|:..:|.|..:|...||..:.......|...||...|...|...|..|::.
Human   894 DEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIR 958

  Fly   556 ATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLN 620
                   :.....:|||.|..:.|..:.:.|.|::       |........|.|.:..:      
Human   959 -------LPSFKVKRKEPPDTTSSGDQKRLRPSTS-------VDEEDEESERERDRDMA------ 1003

  Fly   621 IDSKLLTEIEIITSTFNSRCRI--QDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGP 683
                            ::.|.:  :|.:..|...:                  ||:.|.|:.||.
Human  1004 ----------------DTPCELAKRDPKGVGVRRR------------------PARPLELDSGGE 1034

  Fly   684 ASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKL 748
            ..          :|..||   ...:..::|:||:...|.||:.:.|...::|...:..:.::.: 
Human  1035 ED----------EKESLS---ASSSSSASSSSGSSTTSPSSSASDKEEEQESTEEEEEAEEEEE- 1085

  Fly   749 PLKKRHYLLTPGERPPAEVAFANGKLNA-------------EAWAAAAAAAKSTASTKSQAQFNA 800
                       .|.|.::::.::....:             |:.......|.|.||.|.:...:.
Human  1086 -----------EEVPRSQLSSSSTSSTSDKDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDE 1139

  Fly   801 RSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGG 865
            ....|.:|.|........:|.|....|:|.|                   ||||  |..::....
Human  1140 EETVSIVTSKAEATSSSESSESSEFESSSES-------------------SPSS--SEDEEEVVA 1183

  Fly   866 AAKQKVSAAKDLVQLQSPAGSYP------------PPGV-------FEPSVELEIQIPLSKLNES 911
            ..:::....:::|..:|.|.:.|            .||.       .|..|::|.:....:...|
Human  1184 REEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPS 1248

  Fly   912 VITKAEVESPLLSALDIKEDTK---KEVGQRVVETLLHKTGGNLLL-KRKRKKIN-RTGFPTVRR 971
            ::.    |.||...::...|::   :|.|       |.:.|..||. :...|::. |......|.
Human  1249 MLD----EPPLPVGVEEPADSREPPEEPG-------LSQEGAMLLSPEPPAKEVEARPPLSPERA 1302

  Fly   972 KKRKVSVEQQTTAVI--------------------------DEHEPEFDPDDEPLQ--------- 1001
            .:..:.||.:...::                          |...|...|  |||.         
Human  1303 PEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPP--EPLAEDHPPHTPG 1365

  Fly  1002 ---SLRETRSSNNVNVQAAPNPPLD------CERVPQAGEARETFVARTNQKAPRLSVVALERLQ 1057
               ||.:::|:..|.......|||.      ....||...:..::.|    .:|.||...|    
Human  1366 LCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPA----PSPSLSSGGL---- 1422

  Fly  1058 RPQTPARG--------------------RPRGRKPKNREQAEA-------------APQPPPKSE 1089
             |:||.|.                    .|.||:.:......:             .|.|.|.:.
Human  1423 -PRTPGRDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLAL 1486

  Fly  1090 PEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPN-------------IRLPDG--------- 1132
            |.:..|:.|...|..|:|..|..:.||..|:....|.             :|.|.|         
Human  1487 PAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLL 1551

  Fly  1133 --------IDPNTNFSCKIRLK-RRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEA 1188
                    :.|:|:....:.|. |...:.|...|...:|..|      ||..||...::    ..
Human  1552 LPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPP------PPPPPVEPTKL----PF 1606

  Fly  1189 KRLDS-IPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQ 1252
            |.||: .|:|..|        |||:.....:|...:.|.:....:....|:            .:
Human  1607 KELDNQWPSEAIP--------PGPRGRDEVTEEYMELAKSRGPWRRPPKKR------------HE 1651

  Fly  1253 SLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFE---LPYDIW------------- 1301
            .|:||             .|...|.||.|     |.|...:||   :.||||             
Human  1652 DLVPP-------------AGSPELSPPQP-----LFRPRSEFEEMTILYDIWNGGIDEEDIRFLC 1698

  Fly  1302 --------------------WAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNC 1346
                                |.|.          ||.:....:.....:.:|      :|.|...
Human  1699 VTYERLLQQDNGMDWLNDTLWVYH----------PSTSLSSAKKKKRDDGIR------EHVTGCA 1747

  Fly  1347 KNQG----EKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHA-VAPGVE------RFMTADK 1400
            :::|    :|......||.   :..|....||..:..:...|.|| ...|.|      |.:::..
Human  1748 RSEGFYTIDKKDKLRYLNS---SRASTDEPPADTQGMSIPAQPHASTRAGSERRSEQRRLLSSFT 1809

  Fly  1401 G----------------------------WGVRTKLPIAKGTYILEYVGEVV-------TEKEFK 1430
            |                            ||:....|||....::||||:.:       .||.::
Human  1810 GSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYE 1874

  Fly  1431 -QRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRA 1494
             :.:.|.|:       ..:|...:||..:.|:..||:||||.|||..:..:|....::|:::|:.
Human  1875 DEGIGSSYM-------FRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQH 1932

  Fly  1495 IEEGEELTYDYNFSLFNPSEGQ--PCRCNTPQCRGVI 1529
            |...||:||||.|    |.|..  ||.|.:..|||.:
Human  1933 INVNEEITYDYKF----PIEDVKIPCLCGSENCRGTL 1965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 12/52 (23%)
SET 1392..1512 CDD:214614 40/161 (25%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
SETD1BNP_001340274.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
RRM_Set1B 101..193 CDD:240993
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..660
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..719
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..1462 103/613 (17%)
Trypan_PARP <1237..1308 CDD:330686 15/81 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1501..1541 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1555..1606 12/60 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1668 10/61 (16%)
N-SET 1679..1821 CDD:314603 25/160 (16%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1745..1750 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1767..1800 8/32 (25%)
SET 1834..1949 CDD:214614 38/125 (30%)
PostSET 1950..1966 CDD:214703 6/16 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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