DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and EZH2

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_011514185.1 Gene:EZH2 / 2146 HGNCID:3527 Length:759 Species:Homo sapiens


Alignment Length:622 Identity:142/622 - (22%)
Similarity:215/622 - (34%) Gaps:212/622 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   971 RKKRKVSVEQQTTAVIDEHEPEFDPD-DEP-LQSLRETRSSNNVNVQAAPNPPLDCER------- 1026
            ::|.|...|||....:   .||..|: |.| .:|::..:|.::.:.       |.|.|       
Human   249 KEKYKELTEQQLPGAL---PPECTPNIDGPNAKSVQREQSLHSFHT-------LFCRRCFKYDCF 303

  Fly  1027 -----------VPQAGEARETFVARTNQK-APR-----------LSVVALERLQRPQTPARGRPR 1068
                       .|...:.:.|..|..|:. .|:           .:.:..||::.|.....||.|
Human   304 LHRKCNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR 368

  Fly  1069 GRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGI 1133
            ||.|.|..:         .|.|.|...     :.|....:....|....:..:|.|...:.....
Human   369 GRLPNNSSR---------PSTPTINVL-----ESKDTDSDREAGTETGGENNDKEEEEKKDETSS 419

  Fly  1134 DPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEH 1198
            ....|..|:..:|.:.|:|                   |||   :.|...|||...|: .|.|.:
Human   420 SSEANSRCQTPIKMKPNIE-------------------PPE---NVEWSGAEASMFRV-LIGTYY 461

  Fly  1199 DPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNK 1263
            |...|                             ::::..|.....::....|:|.:..||    
Human   462 DNFCA-----------------------------IARLIGTKTCRQVYEFRVKESSIIAPA---- 493

  Fly  1264 KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIR---- 1324
                     ||..:..||..:|...|          :|.|:.               |||:    
Human   494 ---------PAEDVDTPPRKKKRKHR----------LWAAHC---------------RKIQLKKD 524

  Fly  1325 ---TNVYAESVRPNLAGFDHP------TCNC---KNQGEK--SCLDNCLNR-------------- 1361
               .:||      |....|||      :|.|   :|..||  .|...|.||              
Human   525 GSSNHVY------NYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQ 583

  Fly  1362 ----MVYTECSPS---NCPAGE-------KCRNQKIQRHA-----VAPGVERFMTAD-KGWGVRT 1406
                :...||.|.   .|.|.:       .|:|..|||.:     :||       :| .|||:..
Human   584 CPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAP-------SDVAGWGIFI 641

  Fly  1407 KLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCE 1471
            |.|:.|..:|.||.||::::.| ..|...:|......:..:|:...|:|..|.|:..||.|||..
Human   642 KDPVQKNEFISEYCGEIISQDE-ADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVN 705

  Fly  1472 PNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFS 1508
            |||..:...|||..|:.:||||||:.||||.:||.:|
Human   706 PNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 49/292 (17%)
AWS 1340..1388 CDD:197795 22/91 (24%)
SET_ASH1L 1391..1531 CDD:380951 45/119 (38%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
EZH2XP_011514185.1 EZH2_WD-Binding 47..76 CDD:463308
PRC2_HTH_1 166..257 CDD:436286 2/7 (29%)
preSET_CXC 572..603 CDD:408079 4/30 (13%)
SET_EZH2 622..741 CDD:380995 46/126 (37%)
Blue background indicates that the domain is not in the aligned region.

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