DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and EZH1

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001308008.1 Gene:EZH1 / 2145 HGNCID:3526 Length:753 Species:Homo sapiens


Alignment Length:568 Identity:142/568 - (25%)
Similarity:199/568 - (35%) Gaps:203/568 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1062 PARGRPRGRKPKNREQAEAA-PQP-PPKSEPEIRPAKKRGRQPKQPV-----------------L 1107
            |..|.|...|.:.||..|.: |.. ||:..|.|.....:..|.:|.:                 |
Human   251 PENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFL 315

  Fly  1108 EEPPPTPPPQQKKN---KMEPNIRLPDGID--------------PNTNFSCKIRLKRRKNLEAGT 1155
            .....||...::||   |:||.   |.|.|              .|....|..|.:||.::.:.:
Human   316 HPFHATPNVYKRKNKEIKIEPE---PCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSAS 377

  Fly  1156 QPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSES 1220
                                 .|.....|.||.|..||            ..:.| .|:||.|..
Human   378 ---------------------CSNASASAVAETKEGDS------------DRDTG-NDWASSSSE 408

  Fly  1221 SEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKP-------GLEEQV------- 1271
            :..:..|.:.:|.|..                   ||...|.:.|       |.||.:       
Human   409 ANSRCQTPTKQKASPA-------------------PPQLCVVEAPSEPVEWTGAEESLFRVFHGT 454

  Fly  1272 ------GPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNS---KLPTRNVV-PS--------- 1317
                  ..|.||.... |::..:             :|...|   ||||..:: ||         
Human   455 YFNNFCSIARLLGTKT-CKQVFQ-------------FAVKESLILKLPTDELMNPSQKKKRKHRL 505

  Fly  1318 W--NYRKIR-------TNVYAESVRPNLAGFDHP------TCNC---KNQGEKSCLDN--CLNRM 1362
            |  :.|||:       |.||      |....|||      ||.|   :|..||.|..|  |.||.
Human   506 WAAHCRKIQLKKDNSSTQVY------NYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRF 564

  Fly  1363 ----VYTECSPSNCP-----------------AGE-------KCRNQKIQRHAVAPGVERFM--- 1396
                ..|:|:...||                 |.|       .|:|..|||     |:::.:   
Human   565 PGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQR-----GLKKHLLLA 624

  Fly  1397 TAD-KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMG 1460
            .:| .|||...|..:.|..:|.||.||::::.| ..|...:|......:..:|:...|:|..|.|
Human   625 PSDVAGWGTFIKESVQKNEFISEYCGELISQDE-ADRRGKVYDKYMSSFLFNLNNDFVVDATRKG 688

  Fly  1461 SDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFS 1508
            :..||.|||..|||..:...|||..|:.:||||||:.||||.:||.:|
Human   689 NKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYS 736

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 55/274 (20%)
AWS 1340..1388 CDD:197795 25/86 (29%)
SET_ASH1L 1391..1531 CDD:380951 45/122 (37%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
EZH1NP_001308008.1 EZH2_WD-Binding 45..74 CDD:463308
PRC2_HTH_1 165..268 CDD:436286 6/16 (38%)
SANT 439..480 CDD:238096 8/54 (15%)
preSET_CXC 566..597 CDD:408079 4/30 (13%)
SET_EZH1 614..749 CDD:380994 47/129 (36%)
Blue background indicates that the domain is not in the aligned region.

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