Protein Alignment ash1 and Phf3

DIOPT Version :9

• Sequence 1: NP_001246834.1
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001074549.1
• Gene: Phf3 / 213109
• MGIID: 2446126
• Length: 2025
• Species: Mus musculus
• Alignment Length: 1668
• Identity: 317/1668 - (19%)
• Similarity: 507/1668 - (30%)
• Gaps: 623/1668 - (37%)

  Fly     1 MSCSQNETAAAKVLETQRAQESGSE--NEE---------TDSITDQSSQS--KSIKSATQFSVQR 52
            |.|| .......:::....:|||::  :||         .|.:.|.|.:|  ||.:...|..|:
Mouse    77 MPCS-TVVGLDDIMDEGVVKESGNDTIDEEELILPNRSLRDRVEDNSVRSPRKSPRLMAQEQVR- 139

  Fly    53 SDTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGI 117
                .||....|.|.....::||| |..:.:||  ::.|...|      ::.:.|.:..||
Mouse   140 ----SLRQSTIAKRSNAATLSTKK-PSGKTLST--SKVGVKPA------ERCQGKEEVYAS---- 187

  Fly   118 SKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQS--------------ASK 168
            .||:...:|::|...|...|.            ||.|..|::..:..|              |..
Mouse   188 LKSEHPKESRRSGRHAEQMDV------------APEVSASSVDSSVSSCAGMKEEAEFDPKHACN 240

  Fly   169 PTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQM- 232
            ...::.:.|.:.:.|.|.:.:     :..|:..:|......||..:.|.::..:.:|  |::.:
Mouse   241 NQGEVNVPSPELDCPLLSETS-----ASVEEKNIEALMECKAKTNSSPLFKFPVRED--EQSDLV 298

  Fly   233 ---LGQTVNAKLAEEKVAKAKEETLV-----QTA------------------VPRKRRGRP---- 267
               |..|:..|.|..|..:..||...     |||                  ...|..|..
Mouse   299 SGELNDTIEGKDAGGKPDQESEEVKFPCEGDQTAEEPESSDVSSDSACANKNKAEKNEGAECHLE 363

  Fly   268 -KKVVPTVPAPGNSGPAIN-----------ESADSGVIST------------------TSTTQST 302
             |..|..|..|.|| |..|           ||.|:.:.||                  .||.::|
Mouse   364 LKNTVDIVDKPENS-PQRNELETLGYGEDTESNDARLQSTEFNKSDLEEVDACAFEPEASTLENT 427

  Fly   303 --------------TPSPKMQNENAVPTGSLPIASSSKPK-IDMAYLDKRMYATERVLYPPPR-- 350
                          |.|.||:..|.....|.....:.||| |......|:...||     .||
Mouse   428 ICDVLDQNSKQLNITQSIKMETANLQDDRSGLEPKNIKPKHIKSVTHSKQSMTTE-----TPRKT 487

  Fly   351 ---------SKRRQNNKKTACSSSNKE------------ELQLDPLWREIDVN---KKFRLRSMS 391
                     ||.:.|.|....:|...|            :.|.|.:|:....|   |..:.::.|
Mouse   488 VAAKHEVGHSKTKSNVKAVKRNSGEPEPQPDSQRPVKVRKKQGDKVWKSQSCNSGVKSVKSQAHS 552

  Fly   392 VGAASGTGASTTICSKVLA--------AKSGYVSD----------------------------YG 420
            |........:|...||.|.        ..||:..:                            .|
Mouse   553 VLKRMPQDQNTMQISKPLTHPHSDKLHGHSGFSKEPPHPVQTGHLVHSSQKQSQKPQQQAAVGKG 617

  Fly   421 SVRHQRSSHNH--NSGYKSDASCKSRYSTKSCMSRRSR--------------------------- 456
            | .|.:..|:|  :...|.|...|.|...::...|:.|
Mouse   618 S-SHVKDEHDHPVSEHLKEDDKLKPRKPDRNLQPRQRRSSRSFSLDEPPLFIPDNIATVKKEGSD 681

  Fly   457 -------------AKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLG 508
                         :|.||:   ||:  ..|.|.       |:.....||......:    ||||.
Mouse   682 QTTSIESKYMWTPSKQCGF---CKK--PHGNRF-------MVGCGRCDDWFHGDCV----GLSLS 730

  Fly   509 QS---SEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMM--- 567
            |:   .||..||:....     .....||...::..:...|     ..:.|.:.|    |.|
Mouse   731 QAQQMGEEDKEYVCVRC-----CAEEDKKTDILDTEIFEAQ-----APIEAHSED----KRMECG 781

  Fly   568 -----------NQRKETPAPSKSSCKIKSRRSSAASMCSS---------YVSGVSRMRRRHRRKS 612
                       ::.:.:..|.|...||..|.|......|.         .::.:.::.:.|..:.
Mouse   782 KLTSSKHAVTDDKHRHSDDPGKHKVKILKRESGEGKTSSDSRDNEIKKWQLAPLRKLSQPHLPRR 846

  Fly   613 FSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLT 677
            .|..||    .|:..|...:.||        .:|:..|...||......|::
Mouse   847 SSEEKS----EKIAKESTALAST--------GERVARSGTHEKQETKKKKME------------- 886

  Fly   678 LNGG----GPASTLSKP------------LKRGLKKR------------------KLSEPLVDFA 708
             .||    .||:| |||            ||..|.||                  |:.:.|..|.
Mouse   887 -KGGPNVHPPAAT-SKPSADQIRQSVRHSLKDILMKRLTDSNLKIPEEKAAKVATKIEKELFSFF 949

  Fly   709 MLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGK 773
            .             .::...|.:::....| ...|.::.| .||    :..||..|..:.    :
Mouse   950 R-------------DTDAKYKNKYRSLMFN-LKDPKNNIL-FKK----VLKGEVTPDHLI----R 991

  Fly   774 LNAEAWAAAAAAA---KSTASTKSQAQFNARSVKSALTPKKRH-----------LLEQPTSVSGA 824
            ::.|..|:...||   :....|....:...|.|:.....|..|           :.||..::...
Mouse   992 MSPEELASKELAAWRRRENRHTIEMIEKEQREVERRPITKITHKGEIEIESDAPMKEQEAAIEIQ 1056

  Fly   825 GSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRR-------------------------- 863
            ..||:.|     ::...:|..:..::..:|..:..|.|:
Mouse  1057 EPSANKS-----MEKPDVSEKQKEEVDSTSKDTTSQHRQHLFDLNCKICIGRMAPPIDDLSPKTV 1116

  Fly   864 ----GGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNES----VITKAEVES 920
                |||.|...:.|:.|....|...:.....:||   |.:.:.|.|..:.:    :....||||
Mouse  1117 KVVVGGARKHSDNEAESLADALSSTTNILTSDLFE---EEKQESPKSTFSPTPRPEMPGTVEVES 1178

  Fly   921 PLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGF---PTVRR---KKRKVSVE 979
            ..|:.|                        |.:.|         ||   |:|.:   |...||
Mouse  1179 TFLARL------------------------NFIWK---------GFINMPSVAKFVTKAYPVS-- 1208

  Fly   980 QQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLD-CERVPQAG------------ 1031
                     ..||:..:|.|        .|..|..:.:|....| .|::..:|
Mouse  1209 ---------GSPEYLTEDLP--------DSIQVGGRISPQTVWDYVEKIKASGTKEICVVRFTPV 1256

  Fly  1032 ---------------EARETF-VARTNQKAPR----LSVVALERLQRPQTPARG------RPR-- 1068
                           .:|:.: ||..|.|..:    :.:.|.:::..|..|..|      ||.
Mouse  1257 TEEDQISYTLLFAYFSSRKRYGVAANNMKQVKDMYLIPLGAADKIPHPLVPFDGPGLELHRPNLL 1321

  Fly  1069 -----GRKPKNREQAEAAPQ---PPPKSEPEIRPAKKRGR------------------------- 1100
                 .:|.|....|.|.|.   ..|:|.|.:.|..|:|:
Mouse  1322 LGLIIRQKLKRPHSASAGPSHTGETPESAPIVLPPDKKGKMESCTEEAAEEESDFFNSFTTVLHK 1386

  Fly  1101 ---QPKQPVLEEPPPTPPPQQKKNKMEP--NIRLPDGI------DPNTNFSCKIRLKRRKNLEA- 1153
               :|.||:.|:.|....|..:..|.||  .:|...|:      .|:|.......|.....|::
Mouse  1387 QRNKPSQPLQEDLPTAAEPLMEVTKQEPPKPLRFLPGVLIGWDNQPSTLELANKPLPVDDILQSL 1451

  Fly  1154 -GTQPKKEKPVQPV----TVEEIP-------PEIPVSQEEID----AEAEAKRLD------SIPT 1196
             ||..:..:..||:    |::|||       |::    |:||    .|.:||.:.      |:.|
Mouse  1452 LGTTGQVYEQAQPLVEQSTLKEIPFINDQANPKV----EKIDKVEVTEGDAKEIKVKAENISVST 1512

  Fly  1197 -----EHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLS 1234
                 |......|.|.:|||....|......|.::...|..||
Mouse  1513 SKNSGEETSSVGSSSISPGPLASLSLRGKPPDVSTEAFLTNLS 1555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795
		SET	1392..1512	CDD:214614
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Phf3	NP_001074549.1	PHD_PHF3	697..747	CDD:277108	18/65 (28%)
		TFIIS_M	904..1017	CDD:369395	22/135 (16%)
		PHA03369	<983..1184	CDD:223061	37/212 (17%)
		SPOC	1181..1327	CDD:369497	32/197 (16%)
		SF-CC1	1916..>2025	CDD:273721

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030