DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Ash1l

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_619620.3	Gene:	Ash1l / 192195	MGIID:	2183158	Length:	2958	Species:	Mus musculus

Alignment Length:	2622	Identity:	685/2622 - (26%)
Similarity:	1076/2622 - (41%)	Gaps:	693/2622 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SENEETDSITDQSSQSKSIKSATQFSV------------------QRSDTDGLRMRISAIRPTLG 70
            |..|:.:.|::...:|:....:|..:|                  :.:::....:.|..|..:||
Mouse   586 STAEQMEEISESIGKSQFTAESTHLNVGHRSLGHSLSIECKGIDKELNESKNTHLDIPRISSSLG 650

  Fly    71 VVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFS 135
                |||       :..::||........|:.......|.......::..||..:..:|..|:|.
Mouse   651 ----KKP-------SLTSDSGIHAITPSVVNFTSLFSNKPFLKLGAVTAPDKHCQVAESLSSSFQ 704

  Fly   136 SDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISS-----SDNELPNLVQAAIKRVES 195
            |.     |||..:.|.||  .:.::..:...|...||:..|.     |.:.|.|..:.| |.:::
Mouse   705 SK-----PLKKRKGRKPR--WTKVVARSTCRSPKGLDLERSELFKNVSCSSLSNSSEPA-KFMKT 761

  Fly   196 DTEDTTVEGSFRKAAKDKNLPQYQST------LLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETL 254
            ....:.|:..|.|    :.||:...:      ||.|..:.:..  ..:..||:......:.
Mouse   762 IGASSFVDHDFLK----RRLPKLSKSSAPSLALLTDSEKPSHK--SFITHKLSSSMCVTSD---- 816

  Fly   255 VQTAVPRKRRGRPK-KVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKMQNENAVPTGS 318
            :.:.:.:.:||||| |.:|.:..|    |.......:..:.:..:.:...| |.:|.|..:|:..
Mouse   817 LLSDIYKPKRGRPKSKEMPQLEGP----PKRTLKIPASKVFSLQSKEEQEP-PILQPEIEIPSFK 876

  Fly   319 LPIASSSKPKIDMAYLDKRMYATERVLYPPPRS--------------KRRQNNKKTACSSSNKEE 369
            ..::.|..||  .....||...:...:.||..|              ...:|::.::....::::
Mouse   877 QSLSVSPFPK--KRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLESESENHRSSSDFFESEDQ 939

  Fly   370 LQ----LDPLWR---------EIDVNKKFRLRSMSVGAASGTGASTTICS----KVLAAKSGYVS 417
            ||    ||...|         |::.:||...|:      :|....|.|..    |.|..|
Mouse   940 LQDTDDLDDSHRQSVCSMSDLEMEPDKKISKRN------NGQLMKTIIRKINKMKTLKRK----- 993

  Fly   418 DYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRA 482
               .:.:|..|.:..|..|.....| .::|.|.::....:| .|.:.:..:.|...:..||.|:.
Mouse   994 ---KLLNQILSSSVESSNKGKVQSK-LHNTVSSLAATFGSK-LGQQINVSKKGTIYIGKRRGRKP 1053

  Fly   483 SMLLK-----SSADDTVEDQDILQLAGLSLGQ-------SSEESNEYISKPSLKSLPTTS----- 530
            ..:|.     |.|...|.:|...|.||.:|||       |...|:|.:..|.......||
Mouse  1054 KTVLNGLLSGSPASLAVLEQTAQQAAGSALGQILPPLLPSPASSSEILPSPICSQSSGTSGGQSP 1118

  Fly   531 ----------ASKKYGEINRYVTTGQYFGRGGSLSAT--------------------NPDNFISK 565
                      :|..|..::         .|.||:..|                    |..:.:|:
Mouse  1119 VSSDAGFVEPSSVPYLHVH---------SRQGSMIQTLAMKKASKGRRRLSPPTLLPNSPSHLSE 1174

  Fly   566 MMNQRKETPAPSKSS--------------------------CKIKSRRSS----------AASMC 594
            :.:.::.||:|...|                          |..|.||.|          .:::.
Mouse  1175 LTSLKEATPSPVSESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHISLIPPETSTVL 1239

  Fly   595 SS---------------YVSGVSRMRRRHRRKSFSHNKSLN-IDSKLLTEIEIITSTFNSRCRIQ 643
            :|               |:| ..:|:|:.|::...:.:..| .|...:.|:|.:.|      |:.
Mouse  1240 NSLKEKHKHKCKRRSHDYLS-YDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELIS------RLS 1297

  Fly   644 DDRLTGSS-------------------------------------------GKEKLLADA----- 660
            :.|:|..|                                           |:...:.:|
Mouse  1298 EIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMP 1362

  Fly   661 -------------------------------------NKLQATLAAPSPAQQLTLNGGGPA---- 684
                                                 .:...||..|.|:...|.....|:
Mouse  1363 FMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHA 1427

  Fly   685 -STLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSS-------------------NGNTK 729
             ..|..|.|...||.||   |...|.|:.|.  ||..|.|:                   :.:..
Mouse  1428 GHLLLNPTKYHKKKHKL---LRQEAFLTTSR--TPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKH 1487

  Fly   730 RRHKKSQ---SNDSSSP------------------DDHKLPLKKRHYLLTPGERPPAEVAFANGK 773
            |.|:..|   |.||.|.                  |.:|...|.|.::..|...|      :...
Mouse  1488 REHRSEQPQVSMDSGSSRSVLESLKRYRFGKDTVGDRYKHKEKHRCHMSCPHLSP------SKNL 1546

  Fly   774 LN-AEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVV 837
            :| .|.|.:...:..|:.:...|            ||.:....|...|:|..|.:.::.|
Mouse  1547 INREEQWVSREPSESSSLALGLQ------------TPLQIDCSESSPSLSLGGFTPNSEP----- 1594

  Fly   838 DNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQ 902
                .|..:.:::..|::.|.:......:.::|::.:..|..:|..|.:.|......||.|..||
Mouse  1595 ----ASSDEHMNLFTSAIGSCRVSNPNSSCRKKLTDSPGLFPVQDTALNRPHRKEPLPSSERAIQ 1655

  Fly   903 IPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRT--- 964
                                  :|...:....:..||..|:.      |....|||.....|
Mouse  1656 ----------------------SLAGSQSASDKPSQRSSEST------NCSPTRKRSSSESTSST 1692

  Fly   965 --GFPTVRRKKRKV-----SVEQQTTAVIDEHEPE--------------FDPDDEPLQSLRETRS 1008
              |.|:  |..|.|     ||:.....::...|.|              ..|...|..|..:.|:
Mouse  1693 VNGVPS--RSPRLVASMDDSVDSLLQRIVHHDEQESMEKNGDASITTVSAPPSSSPGHSYSKERA 1755

  Fly  1009 ---SNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGR 1070
               |:::.|.|.||.  .|..:|...|..   .:|.:....:.|||  |.:||         :.|
Mouse  1756 LGKSDSLLVPAVPND--SCSNIPLLSEKS---ASRCSPHHIKRSVV--EAMQR---------QAR 1804

  Fly  1071 KPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQP---VLEEP-PPTPPPQQKKNKMEP------ 1125
            |..|.::..|..:...... :|..|||..||.:..   |...| .|...|.|....|:.
Mouse  1805 KMCNYDKILATKKNLDHVN-KILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQF 1868

  Fly  1126 -NIRLPDGIDPNTNFS------------CKIRLK-------RRKN--LEAGTQPKKEKPVQPVTV 1168
             :..|.:|.|.:.:.|            ..:.|.       :|||  ||..|: ||:|.| |...
Mouse  1869 VSPELNEGEDMSLHLSPDTVTDVIEAVVQSVNLTSEHKKGVKRKNWLLEEQTR-KKQKTV-PEEE 1931

  Fly  1169 E--------EIPPEIPVSQEEIDAEAEAKRLDSIPTEHD----PLPA---SESHNPGPQDYASCS 1218
            |        |.|.||| |..|..||         |:|.:    |:.|   .|...|.|.
Mouse  1932 EQENNKSFIETPVEIP-SPLETPAE---------PSEPENTLQPVLALIPREKKAPRPP------ 1980

  Fly  1219 ESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYK------QSLMPPPAKVNKKPGLEEQVGPASLL 1277
                              ||.|..|||:|:.||      :.:.....|:...|| |.:.|   |.
Mouse  1981 ------------------KKKYQRAGLYSDVYKTIDPKSRLIQLKKEKLEYTPG-EHEYG---LF 2023

  Fly  1278 PPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHP 1342
            |.|.:..||||:..:||:|||||.|.:.:::|..:..||.  |:|||:|||.: |:| |:|::..
Mouse  2024 PAPIHVGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPL--YKKIRSNVYVD-VKP-LSGYEAT 2084

  Fly  1343 TCNCKNQGE---KSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGV 1404
            |||||...:   |.|.|:|||||::.||||:.||.||:|.||:||||.....:|||...:||||:
Mouse  2085 TCNCKKPDDDTRKGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGI 2149

  Fly  1405 RTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHS 1469
            |||.|:..|.:|:||:||||:|:||:.||...|.|.:.||||:||.|:|||..|||::.||:|||
Mouse  2150 RTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHS 2214

  Fly  1470 CEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQ 1534
            |:||||||||||||:.|:.|:|.:.:..|.||||||||..||..:.|.|:|...:|||:||||||
Mouse  2215 CDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQ 2279

  Fly  1535 RVKPLPAVEAKPSG----EGLSGRNGRQRKQKAKK---HAQRQAGKDISSAVAVA---KLQPLSE 1589
            |:..||:.:...|.    :....:..|:.|.|.||   |...:..::|::...:.   :::|:|.
Mouse  2280 RMNGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQLQMKPMSN 2344

  Fly  1590 KEKKLVRQFNTFLVRNFEKI--RRCKAKRASD---AAATASSPALGTTNGDIPGRRPSTPSSPSL 1649
            :|:..|.:.:.|||||:|||  ::.:.|...|   |:.......|...:|:|        .|...
Mouse  2345 RERNFVLKHHVFLVRNWEKIHQKQEEVKHTRDIHSASLYTRWNGLCRDDGNI--------KSDVF 2401

  Fly  1650 AAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDIC--------SAMETLKMSDLLTTVS 1706
            ..|.|||.:.|:::||.|..|..:.|:.:.|::|.:.::||        |:.:|| .:.||....
Mouse  2402 MTQFSALQTARSVRTRRLAAAEENLEVARAARLAQIFKEICDGIISYRDSSQQTL-AAPLLNLPP 2465

  Fly  1707 SKKKKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGK 1771
            .||.......:|..|         :..:|:.|:..|:|||.:.||..|.::|..|::.:|.....
Mouse  2466 KKKNADYYEKISDPL---------DLSTIEKQILIGYYKTVEAFDADMLKVFRNAEKYYGRKSPI 2521

  Fly  1772 EKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAKERDSPI 1836
            .:.:..|:.:|...:..:..|:.||:|::            :||.:..:.:|.:.....|:
Mouse  2522 GRDVCRLRKAYYSARHEASAQIDEIVGET------------ASEADSSETSVSEKESGHEK---- 2570

  Fly  1837 VPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNYQCERCE 1901
                             |:|||||||||||||||||||.|||||||.:|...:.|.::|.||:|:
Mouse  2571 -----------------DDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNTDVEHYLCEQCD 2618

  Fly  1902 PREVDREIPL---EEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTKKHTYET 1963
            ||.||||:|:   ..:.:.|..|::.|:|.||.:||||.||::||.....:...|    :.:|..
Mouse  2619 PRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPV----RQSYRL 2679

  Fly  1964 IGAIDYQECDIFRVEHLWKNELGKRFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELV 2028
            :..|:..:.||||:|.|||||..:||.||||:.|||||.|.||||||.||:.||.|||::|:|.|
Mouse  2680 LSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAV 2744

  Fly  2029 IGRCWVLDRTTFCKGRPMECNDEDHCYICELRVDKTARFFSKAKAN-HPACTKSYAFRKFPEKIK 2092
            :|.|.|||..|:|||||....::| .|||:.|:||:|..|.|...| :|.|||.|||..||:|:.
Mouse  2745 VGTCCVLDLYTYCKGRPKGIKEQD-VYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLT 2808

  Fly  2093 ISKSYAPHDVDP--------SLLKTRKQKTEL-DVGAGPTTM--------------HKVSGRQEQ 2134
            ..:.::||.|..        |..|:.:.|..| |:|.....:              .:|...:|.
Mouse  2809 PKRDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAAREVPSPEEP 2873

  Fly  2135 HQAKMVG------RKPRGISAPADATAVHVVTPVAPNKQMLKKRKSRLENVLITMKLKCLDAQTA 2193
            .|.:..|      :||...|..|...:    ||    ::....::.||..:|:.: |:.:..:.|
Mouse  2874 DQERATGDIGDAEKKPEESSQEAQLAS----TP----EERRHSQRERLNQILLNL-LEKIPGKNA 2929

  Fly  2194 QEQPIDLSYLL---SGRGARQR 2212
                ||::|||   |||..|:|
Mouse  2930 ----IDVTYLLEEGSGRKLRRR 2947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	28/50 (56%)
		SET	1392..1512	CDD:214614	70/119 (59%)
		Bromo_ASH1	1680..1787	CDD:99955	27/114 (24%)
		PHD_ASH1L	1858..1900	CDD:277023	29/41 (71%)
		BAH_polybromo	1929..2073	CDD:240068	72/143 (50%)
Ash1l	NP_619620.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..137
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..580
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..843		9/23 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..963		15/87 (17%)
		motB	<1061..1187	CDD:183756	27/134 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1094..1126		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1149..1219		7/69 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1279		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1599		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1613..1704		23/120 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1722..1754		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1921..1941		6/21 (29%)
		Catalytic domain. /evidence=ECO:0000250	2059..2278		121/222 (55%)
		AWS	2082..2133	CDD:197795	28/50 (56%)
		SET_ASH1L	2136..2276	CDD:380951	78/139 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2278..2334		13/55 (24%)
		Bromo_ASH1	2432..2537	CDD:99955	27/114 (24%)
		PHD_ASH1L	2575..2617	CDD:277023	29/41 (71%)
		BAH_polybromo	2654..2788	CDD:240068	69/138 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2814..2846		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2861..2909		10/55 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848374
Domainoid	1	1.000	149	1.000	Domainoid score	I4431
eggNOG	1	0.900	-	-		E2759_KOG1083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.721928	Normalized mean entropy	S5577
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007422
OrthoInspector	1	1.000	-	-		oto95017
orthoMCL	1	0.900	-	-		OOG6_106446
Panther	1	1.100	-	-	LDO	PTHR46147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X5557
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.680