DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ash1 and set-12

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_509306.2	Gene:	set-12 / 187229	WormBaseID:	WBGene00019584	Length:	389	Species:	Caenorhabditis elegans

Alignment Length:	320	Identity:	90/320 - (28%)
Similarity:	138/320 - (43%)	Gaps:	66/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1343 TCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADK-GWGVRT 1406
            :|.|   |.....:.|.|...:.|| |..|   ..|.||:.::.... |||.|:|.:. |.|:|.
Worm    56 SCKC---GTDCTTEECSNFANHREC-PRGC---SNCENQRFRKRQFC-GVETFLTDNGIGHGLRA 112

  Fly  1407 KLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND--THHYCLHLDGGLVIDGQRMGSDCRFVNHS 1469
            ...||.|..||||.||.:|:.|..:|:.. |..|  .|.|...:.....:|..|.|:..||:|||
Worm   113 TEEIATGKLILEYRGEAITKAEHNKRVKR-YKKDGIKHSYSFEVGRNYYVDPTRKGNSARFINHS 176

  Fly  1470 CEPNCEMQKWSV--NGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIG-- 1530
            |.||..::.|:|  ..:..:.:||.:.|:.|||:|:||..|..|   .|||:|....|||.||
Worm   177 CNPNALVKVWTVPDRPMKSLGIFASKVIKPGEEITFDYGTSFRN---DQPCQCGEAACRGWIGKP 238

  Fly  1531 ----------------GKSQRVKPLPAVEAKPSGEG----LSG-------RNGRQRK-------- 1560
                            |:..::.|...:....:|.|    |||       |.||:||
Worm   239 STSEVPKDVSKELKKRGRKPKMDPTAPISTTSTGGGDKGKLSGTIPVPKSRRGRKRKTDVTAPVP 303

  Fly  1561 --QKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKKLVRQFNTFLVRNFEK----IRRCKA 1614
              .|.|:|:.....:....    ..::|.||::  :....|..|.:.::.    :..|::
Worm   304 LATKTKRHSPPAENESEDK----ENVKPPSEED--ITNAMNNLLNKTYDNQNGVLDECRS 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	12/44 (27%)
		SET	1392..1512	CDD:214614	46/124 (37%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
set-12	NP_509306.2	AWS	53..94	CDD:197795	12/44 (27%)
set-12	NP_509306.2	SET	97..221	CDD:214614	47/127 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940