Protein Alignment ash1 and set-32

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_492529.2
• Gene: set-32 / 183391
• WormBaseID: WBGene00008062
• Length: 517
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 100/548 - (18%)
• Similarity: 177/548 - (32%)
• Gaps: 182/548 - (33%)

  Fly  1071 KPKNREQAEAAP-------------QPPPKSEPEIRPAKKRGRQPKQPVLEEPP---PTPPPQQK 1119
            |.|.|:.:...|             .||.|:|.:.......|.:.::..|:|..   .|.|  ..
 Worm    10 KKKLRQHSSRGPITEMLASNMCIFEAPPFKAEQDFPIYLAAGYEERRTFLKESACLVETKP--DV 72

  Fly  1120 KNKMEPNIRLPDGI--DPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEI 1182
            :|..:.::::.:.|  ||:.|.:.|:            .||.::.|:...:..:.....:||..
 Worm    73 ENYSQSHVKVLNKIRNDPHLNGNWKL------------LPKYDEDVKGTMMRILGQRAMISQGR- 124

  Fly  1183 DAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFS 1247
                          ||              :.::|.:|.:|         :..:..||:..
 Worm   125 --------------EH--------------EISTCPDSGQD---------VPLLSPTYITP---- 148

  Fly  1248 NHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYC----EKYLRRTEMDFELPYDIWWAYTNSK 1308
                          .|:..:.|.:...:|...|.|.    ||.     ...::|..:.:.||::.
 Worm   149 --------------RKRIRVTENLTFNTLDIVPVYSDLPDEKL-----TSIQIPDTLLFEYTDTN 194

  Fly  1309 L----PTRNVVPSWNYRKIRTNVY---AESVRPNLAGFDHPTCNC-----KNQG----------- 1350
            :    ..||:..:....:...|..   ..|..|.:..:::..|.|     |.||
 Worm   195 VLNPCSARNIAKACIMSQKEENTIRCDCCSSNPIVPCYENENCPCYKLNQKLQGLQINSSSHPPT 259

  Fly  1351 ------------EKSCLDNCLNRMVYTECSPSNCPAGEKCRNQK--IQRHAVAPGVERFMTADK- 1400
                        ..|..|.|:.    ..||.: |.....|.|..  |....:.| :|.:.:.:.
 Worm   260 KFASFDPVMFSNSNSTFDRCIG----FSCSEA-CGCKGNCTNNSLLILNKKLFP-LEIYRSNENV 318

  Fly  1401 GWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHL---DGG----------- 1451
            |:|:|:.:.|..||.:||:.||:|...:..:        |:..|...|   |..
 Worm   319 GFGLRSSVLIPAGTAVLEFTGEIVERNQLDR--------DSQDYAYQLTDKDNSNWRRLLDTMKF 375

  Fly  1452 ---------------LVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLS----RMVLFAKRAIEE 1497
                           ..||.:..|:..|.:.|||.||.|:.:....|||    .:|..:...|..
 Worm   376 SDDYKKFLKKLSYEEFFIDPKAKGNVGRMICHSCSPNLEIVRVYQKGLSPAHVHLVFISLLNIYP 440

  Fly  1498 GEELTYDYNFSLFNPSEGQPCRCNTPQC 1525
            |..||.||.::.........|.|.:..|
 Worm   441 GTPLTMDYGYNYMKNHLNGKCECGSFAC 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	34/227 (15%)
		AWS	1340..1388	CDD:197795	14/77 (18%)
		SET_ASH1L	1391..1531	CDD:380951	39/169 (23%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
set-32	NP_492529.2	SET	307..455	CDD:214614	37/156 (24%)