DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Nsd1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_032765.3	Gene:	Nsd1 / 18193	MGIID:	1276545	Length:	2691	Species:	Mus musculus

Alignment Length:	2459	Identity:	484/2459 - (19%)
Similarity:	792/2459 - (32%)	Gaps:	886/2459 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PKSRKMSTQDTESGCSEAKNRAVSKKVKVK-RKKLASSSGISKSDKVSKSKKSQISAFSS---DS 138
            |..||...|         |.:....||..| ..|..:|.|:::...|.|..|:|....||   ||
Mouse   397 PVLRKRGKQ---------KEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNQKCVSSSVKLDS 452

  Fly   139 EDDLPLK--VHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTT 201
            |:|:|.:  .:...:..:||:..:::.      ..|...|:.:.|.|    .|..||...::
Mouse   453 EEDMPFEDCTNDPDSEHLLLNGCLKSL------AFDSEHSADEKEKP----CAKSRVRKSSD--- 504

  Fly   202 VEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGR 266
               :.::.:..|:|..::|                            .|||          |||:
Mouse   505 ---NIKRTSVKKDLVPFES----------------------------RKEE----------RRGK 528

  Fly   267 PKKVVPTVPAPGN------SGPAINESADSGV--ISTTSTTQSTTPSPKMQNENAVPTGSLPIAS 323
                     .|.|      ||...::.|.:.:  |:.:.|..||.|            ||...:|
Mouse   529 ---------IPDNLGLDFISGGVSDKQASNELSRIANSLTGSSTAP------------GSFLFSS 572

  Fly   324 S----SKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKK 384
            |    :|...:....|.....:|..|......::::......|||    ::||..:...   :::
Mouse   573 SVQNTAKTDFETPDCDSLSGLSESALISKHSGEKKKLQPGQVCSS----KVQLCYVGAG---DEE 630

  Fly   385 FRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYK------SDASCKS 443
            .|..|:||...|..|     ||.:                  ....||||::      :||..|
Mouse   631 KRSNSVSVSTTSDDG-----CSDL------------------DPTEHNSGFQNSVLGITDAFDK- 671

  Fly   444 RYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLG 508
               |::.:|        .::::.:.|........::::.|::..|.||..:.....::.....|.
Mouse   672 ---TENALS--------VHKNETQYSRYPVTNRIKEKQKSLITNSHADHLMGSTKTMEPETAELS 725

  Fly   509 QSSEESNEYISKPSLKSLP-------TTSASKKYGEINRYVTTGQYFGRGGSLSAT------NPD 560
            |.: .|:..||.|..|..|       ||..|...|..|....|     :||..:.|      ...
Mouse   726 QVN-LSDLKISSPIPKPQPEFRNDGLTTKFSAPPGIRNENPLT-----KGGLANQTLLPLKCRQP 784

  Fly   561 NFISKMMNQRKETPAPSKSS----------CKIKSRRSSAASMC-SSYVSGVSRMRRRHRRKSFS 614
            .|.| :..:.||:||.:::|          |...:..|..|::. |....|:..:...|.:...|
Mouse   785 KFRS-IKCKHKESPAVAETSATSEDLSLKCCSSDTNGSPLANISKSGKGEGLKLLNNMHEKTRDS 848

  Fly   615 HNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLN 679
            .:....:...:|:|::.:  ::.|......|..|..:.|..|.:.|          |....:.:.
Mouse   849 SDIETAVVKHVLSELKEL--SYRSLSEDVSDSGTAKASKPLLFSSA----------SSQNHIPIE 901

  Fly   680 GGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSAS---------ASGTPNGS------GSSNGNTK 729
            .....|||...|| .:...|..|..:..|...||         :||:|.|:      |||..|::
Mouse   902 PDYKFSTLLMMLK-DMHDSKTKEQRLMTAQNLASYRTPDRGDCSSGSPVGTSKVLVLGSSTPNSE 965

  Fly   730 RRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAA-------AAK 787
            :....:|.:...||......|.        ||...:..:.|:.|....|.....:       ..:
Mouse   966 KPGDSTQDSVHQSPGGGDSALS--------GELSSSLSSLASDKRELPACGKIRSNCIPRRNCGR 1022

  Fly   788 STASTKSQAQFNARSVKSALTPK------KRHLLEQPT--------------SVSGAGSSASNSP 832
            :..|:|.:...:|:.||.::.||      ||.....|.              ||:|.....:..|
Mouse  1023 AKPSSKLRETISAQMVKPSVNPKALKTERKRKFSRLPAVTLAANRLGNKESGSVNGPSRGGAEDP 1087

  Fly   833 -----------LR-----------------------------------------IVVDNNSISGG 845
                       ||                                         :..:|:.:.|
Mouse  1088 GKEEPLQQMDLLRNEDTHFSDVHFDSKAKQSDPDKNLEKEPSFENRKGPELGSEMNTENDELHG- 1151

  Fly   846 KLLDISPSSLCSLKQQRR----------------GGA--------AKQKVSAAKDLVQLQSPAGS 886
             :..:.|........|||                .||        |.||  |.:|.::.::|..|
Mouse  1152 -VNQVVPKKRWQRLNQRRPKPGKRANRFREKENSEGAFGVLLPADAVQK--AREDYLEQRAPPTS 1213

  Fly   887 YPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTG-G 950
            .|.....:|:.....:....:||  |..|:.|.         ..|.:||.|   :.:|:.:|. .
Mouse  1214 KPEDSAADPNHGSHSESVAPRLN--VCEKSSVG---------MGDVEKETG---IPSLMPQTKLP 1264

  Fly   951 NLLLKRKRKKINRTGFPT-------------VRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPL-- 1000
            ...::.::|::.:   |:             ...||::..|::|.      |:.....:||.|
Mouse  1265 EPAIRSEKKRLRK---PSKWLLEYTEEYDQIFAPKKKQKKVQEQV------HKVSSRCEDESLLA 1320

  Fly  1001 ---QSLRETRSSNNVNVQAAPNPP-LDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQT 1061
               .|.:..:...|..:.....|| |:.|.....|...::.:..|:.:.|:|:      |..|..
Mouse  1321 RCQPSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSDLGVTHAELPQLT------LSVPVA 1379

  Fly  1062 PARGRPRGRKPKNREQAEAAPQPPPKSEPEI--RPA---KKRGRQPKQPVLEEPPPTPPPQQKK- 1120
            |                ||:|:|..:||..:  .|.   .||.|:|.:.:||.....|....||
Mouse  1380 P----------------EASPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKG 1428

  Fly  1121 -----NKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGT-----QPKKEKPVQPVTV------- 1168
                 .|.....|..:||..:...|      ..|....||     :|:|.|..:.||.
Mouse  1429 DLGLSRKCFEASRSGNGIVESRATS------HLKEFSGGTTKIFDKPRKRKRQRLVTARVHYKKV 1487

  Fly  1169 --EEIPPEIPVSQEEI---DAEAEAKRLDSIPTEHDP---------------------------- 1200
              |::..:.|.|:.|:   ...|..|.:.....||||
Mouse  1488 KKEDLTKDTPSSEGELLIHRTAASPKEILEEGVEHDPGMSASKKLQVERGGGAALKENVCQNCEK 1552

  Fly  1201 ---------------------LP--------ASESHNPGPQDYASCSESSED------------- 1223
                                 ||        .:|.|. |......|.:|.||
Mouse  1553 LGELLLCEAQCCGAFHLECLGLPEMPRGKFICNECHT-GIHTCFVCKQSGEDVKRCLLPLCGKFY 1616

  Fly  1224 ------------------------------------KASTTSLRKLSKVKKTY------LVAG-- 1244
                                                .||...|.:..:....|      |.||
Mouse  1617 HEECVQKYPPTVTQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSK 1681

  Fly  1245 -------LFSNHYKQ----------------------SLM----PPPA----------------- 1259
                   :..||:..                      ||:    .|.|
Mouse  1682 ILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYC 1746

  Fly  1260 ---KVNKKPGLEE----QVG-----PASLLPP---PPYCEKYLRRTEMDFELPY----DIWWAY- 1304
               |..|||...|    :||     ||.:..|   |...:| :|....:|.:.:    |..|.:
Mouse  1747 NDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDK-MRHDVGEFPVLFFGSNDYLWTHQ 1810

  Fly  1305 ----------------------------------------------------TNSKLPTRNVVPS 1317
                                                                .|.|.|     |.
Mouse  1811 ARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKP-----PP 1870

  Fly  1318 WNYRKI-----RTNVYAESVRPNLAGFDHPTCNCKNQGEKSC-LDN-CLNRMVYTECSPSNCPAG 1375
            :.:.|:     |..::...:.      :.|.||||...|..| :|: |:|||:..||.|:.||||
Mouse  1871 YKHIKVNRPIGRVQIFTADLS------EIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAG 1929

  Fly  1376 EKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND 1440
            .:|:||...:... |.||.|.|..:|||:|||..|.||.::.|||||::.|:|.:.|:.....:|
Mouse  1930 VRCQNQCFSKRQY-PDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHD 1993

  Fly  1441 -THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYD 1504
             |:.|.|.||...:||....|:..||:||.|:||||.|||||||.:|:.|||...|:.|.|||::
Mouse  1994 ITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFN 2058

  Fly  1505 YNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQR 1569
            ||.......: ..|:|..|.|.|.:|   .|.|..|.|..:.|           ||.|.|.|.:|
Mouse  2059 YNLECLGNGK-TVCKCGAPNCSGFLG---VRPKNQPIVTEEKS-----------RKFKRKPHGKR 2108

  Fly  1570 QAGKDISSAVAVAKLQPLSEKEKKLVRQFNTFLVRNFEKIRRCKAKRA-----SDAAATASSPAL 1629
            ::..:::             ||    |:...|...:..::..||....     :|.......||
Mouse  2109 RSQGEVT-------------KE----REDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPA- 2155

  Fly  1630 GTTNG---------DIPGRRPSTPSSPSLAAQISALCSPRNIKTR------------GLTQAVHD 1673
                |         |:.|:.         ||....:|.....|..            .|:...||
Mouse  2156 ----GKWECPWHQCDVCGKE---------AASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHD 2207

  Fly  1674 PELEKMAKMAVVLRDIC--SAMETLKMSDLLTTVSSKKKKPIKTTLSGKLGSTAATSKVEFRSIQ 1736
            |               |  :.:|..::.:.:...::....|  .|...:..|..||
Mouse  2208 P---------------CGPNPLEPGEIREYVPPTATSPPSP--GTQPKEQSSEMAT--------- 2246

  Fly  1737 AQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEGKEKALQSLKDSYEQQKIASYVQLVEILGD-- 1799
                ||..|:.|...|..|.|.:..|...|..:      :.|......::..|...|::.:.|
Mouse  2247 ----QGPKKSDQPPTDATQLLPLSKKALTGSCQ------RPLLPERPPERTDSSSHLLDRIRDLA 2301

  Fly  1800 -----SESL-QSFKPKEVLSSEEEP-GKIAVKKSPGAKERDSPIV-------PLKVT-------- 1842
                 |:|| .|.:|::...::|.| .:...:.||..:...||.|       ||::|
Mouse  2302 GSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRASPMTRPSSSPSVSSLPLERPLRMTDSRLDKSI 2366

  Fly  1843 ---PPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMV------WQHTECTKADIDADNYQCE 1898
               .|....:|.:|....:|...   .|..|.....|..:      ..|...|           :
Mouse  2367 GAASPKSQAVEKTPASTGLRLSS---PDRLLTTNSPKPQISDRPPEKSHASLT-----------Q 2417

  Fly  1899 RCEPRE----------VDRE---IPLEEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDI-PIKDE 1949
            |..|.|          |.:|   .|:::.|:..||..:.:...||..||.:.....::: |..||
Mouse  2418 RLPPPEKVLSAVVQSLVAKEKALRPVDQNTQSKHRPAVVMDLIDLTPRQKERAASPQEVTPQADE 2482

  Fly  1950 ----------------------------------SGKVLPTKKHTYETIGAIDY 1969
                                              ||||....:|.::.:.::.:
Mouse  2483 KTAMLESSSWPSSKGLGHIPRATEKISVSESLQPSGKVAAPSEHPWQAVKSLTH 2536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	22/49 (45%)
		SET	1392..1512	CDD:214614	57/120 (48%)
		Bromo_ASH1	1680..1787	CDD:99955	17/108 (16%)
		PHD_ASH1L	1858..1900	CDD:277023	6/47 (13%)
		BAH_polybromo	1929..2073	CDD:240068	12/76 (16%)
Nsd1	NP_032765.3	MSH6_like	320..430	CDD:99898	11/41 (27%)
		TNG2	<1453..1587	CDD:227367	21/139 (15%)
		PHD1_NSD1_2	1546..1587	CDD:277118	2/40 (5%)
		PHD2_NSD1	1593..1639	CDD:277120	4/45 (9%)
		PHD3_NSD1	1640..1693	CDD:277123	7/52 (13%)
		PHD4_NSD1	1710..1749	CDD:277126	4/38 (11%)
		WHSC1_related	1755..1849	CDD:99899	13/94 (14%)
		AWS	1902..1940	CDD:375420	17/37 (46%)
		SET_NSD1	1942..2083	CDD:380987	63/142 (44%)
		PHD5_NSD1	2121..2163	CDD:277129	7/46 (15%)
		C5HCH	2162..2211	CDD:375464	11/72 (15%)
		PHA03307	2255..>2576	CDD:223039	54/302 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848350
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.880