DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and set-6

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_510003.2	Gene:	set-6 / 181371	WormBaseID:	WBGene00008206	Length:	708	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	155/752 - (20%)
Similarity:	261/752 - (34%)	Gaps:	217/752 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   858 LKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEI-----QIPLS------KLNES 911
            :::.|.||::...:|.|           :.|...:.:...||.|     :.|:|      :.|.|
Worm     1 MERSRTGGSSTYSMSTA-----------NVPIITISDDDDELTIWEEPRKSPISSNSYSDERNHS 54

  Fly   912 V--ITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKR 974
            :  .:.:.||..::..:   .|.:.|..:|..:.::.:...|.|.:::|:.:.  .|..:..|:|
Worm    55 LSSTSNSSVERSIIITI---SDDESEATERNQQEVVDRAISNNLTEKRRRSVE--SFHRLHSKER 114

  Fly   975 KVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVA 1039
            |:.|                      :|.:::|:|:: :::|:.:......:.......|:|: :
Worm   115 KLEV----------------------KSRKKSRTSSS-SMEASTSCTFPARQTKTKRHKRKTY-S 155

  Fly  1040 RTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQ 1104
            ..:..||..|.:..|  .|...||| ....|.|...|.          |:..:...::..::..:
Worm   156 TISSFAPHHSTICAE--LRNVNPAR-IADFRHPSIFEY----------SDMSLNERREHWKKEMK 207

  Fly  1105 PVLEEPPPTPPPQQKKNKM----EPNIRLPD--GIDPNTNFSCKIRLKRRKNLEAGTQPK----- 1158
            .:           :|.|.:    |..:|..|  .:||..|.    ..:|....|..|:..
Worm   208 VI-----------KKHNDIRLMHEEAVRFDDIIELDPTLNG----YYRRFMGAEQSTRALFMAVR 257

  Fly  1159 ---------KEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRL---DSIPTEHDP--LPASESHNP 1209
                     .|:|.:....||||.|:....|::...|...|:   |.|...:|.  :|.
Worm   258 CLATFGRNFYEEPERDHGEEEIPEELDRYFEKLIYVAPRTRIRITDDIHLSNDTHRIPV------ 316

  Fly  1210 GPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGLEEQVGPA 1274
                      .::.|..|.   |..|:....|...:.:|...:...|...:..|..|..|.|...
Worm   317 ----------YTDAKGETL---KTVKIPNPLLYDHIINNMVDKVKEPLLYEAIKIAGSSENVIRC 368

  Fly  1275 SLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESV----RP- 1334
            ......|....:..:     :.|..|    .|..|.:||.....| .|::.:.:...:    .|
Worm   369 KCCSQDPVVNCFDNK-----DCPCFI----ANQFLQSRNKTTDTN-EKLKFHTFQPLMYNDGNPT 423

  Fly  1335 --NLAGFD-HPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFM 1396
              |..||. .|.|.||..        |.|...|.                 ||:...:..:.|
Worm   424 YYNTVGFACSPKCACKGA--------CTNNATYL-----------------IQKKLYSIEIYR-- 461

  Fly  1397 TADK--GWGVRTKLPIAKGTYILEYVGEVVT--------------------EKEFKQRMASIYLN 1439
             ||.  |:|:|:.|.|..||.|:||.||:|.                    :|.....:...|.|
Worm   462 -ADPQIGFGIRSTLFIPAGTPIIEYCGELVDGERLHSSLENYSYQLTDCEGDKHLYNLLREKYKN 525

  Fly  1440 D-----------THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLS----RMVL 1489
            :           .||:  ||      |.:..||..||.||||.||.|..:....|.:    ||:.
Worm   526 NPEYYDVLDELSKHHF--HL------DAKMQGSVGRFANHSCTPNMEPLRLFKEGFTPANMRMIF 582

  Fly  1490 FAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            |..:.|..||.||.||. |.:.....|.|.|.|..||
Worm   583 FTLKDIFPGEPLTLDYG-SEYKVFRRQRCLCRTFACR 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	9/48 (19%)
		SET	1392..1512	CDD:214614	47/156 (30%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
set-6	NP_510003.2	SET	455..603	CDD:214614	47/159 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840