DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and set-5

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_001256612.1	Gene:	set-5 / 179973	WormBaseID:	WBGene00008145	Length:	1558	Species:	Caenorhabditis elegans

Alignment Length:	1253	Identity:	228/1253 - (18%)
Similarity:	394/1253 - (31%)	Gaps:	434/1253 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVVATKKPPK---SRKMSTQ 86
            :.|||..|..:|.|......::||    ||:..:.:    :.|.:...|.:..||   .||.||
Worm   451 KKEETGIINGESIQVTKKAESSQF----SDSSPILL----VNPHVHTEAPEPTPKEHMERKWST- 506

  Fly    87 DTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRA 151
             |.||......|.|:.:         ||...|:.|...:..|.::||.||         .|.
Worm   507 -THSGSMGELQRPVTSQ---------SSRKSSRWDVTEEDLKRKLSATSS---------THN--- 549

  Fly   152 PRVLLSAIIQAAQSAS-----------KPTLD-----IGISSSDNELPNLVQAAIKRVESDTEDT 200
            ||...|..::..||..           ||..|     ..:.:::.|:|         :|:.:...
Worm   550 PRERASVELETRQSEEIQKLQRLVNVIKPRDDSLEGTSNLDAANREIP---------IEASSTAP 605

  Fly   201 TVEGSFR------KAAKD-------------KNLPQYQSTLLQDFMEKTQM------LGQTVNAK 240
            .:..||:      |:..|             |:.|..|...:...:.||.:      |.:.||.|
Worm   606 LLSRSFQFWRERSKSPDDSAQNHSDLHGTSLKSRPDAQKNPIPQAVAKTMLKFPVSTLDRPVNTK 670

  Fly   241 ----LAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQ- 300
                ..:|.....|....|..||.     .|:|.|....|..:     |.:|....:||.:|..
Worm   671 KSMAFGQEAQIMPKSSVFVNNAVK-----IPQKFVIVKEASSD-----NPNAAENPVSTQNTVDL 725

  Fly   301 ----STTPSPKMQNENAVPTGS-LPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKT 360
                |.||..|:.:||   .|| .|.:|..:.|:|      .:..|.::|...|.|.:
Worm   726 HDIPSKTPQQKVTSEN---RGSGAPNSSEDQQKLD------EIAPTTQILPEDPVSVQ------- 774

  Fly   361 ACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQ 425
              |.|:..|:..:...:.:...:        :|..:.:.:..|:                |||::
Worm   775 --SRSDVCEVTAETSQKSVGPER--------IGGDAQSSSENTV----------------SVRNR 813

  Fly   426 RSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCK------ESGKSGLRMRRKRRASM 484
            ...|    |..|....|...|.||..|.....:......:.:      .|.:|...::.:|..|.
Worm   814 VDLH----GIPSKTPQKLVQSGKSAQSSTENQQQIEMTPEARILSKNPISAQSKTPVKEERPESH 874

  Fly   485 LLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPT-----------TSASKKYGEI 538
            .|..|...|.....|.:::..|....|:.|...:....|:.:|:           .|.|:...:|
Worm   875 SLSESFASTQHPMKISEISENSTQNRSDSSRIGLRSVKLEQIPSRTIKVEEPTDFPSNSEPEAQI 939

  Fly   539 NRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETP-------------------APSKSS---- 580
            .....|.:    ....|:..|:..|.:...:..|.|                   ||..|:
Worm   940 PLETRTLE----PSEASSVQPEPPIDQEEAENDENPEILTPNSPTIDQDEAQNSDAPDASADSDL 1000

  Fly   581 --------------CKIKSRRSSAASMCSSYVSGVSRMRRR------------------HRRKSF 613
                          .:|..:.|..|.....:....:||::.                  ||..::
Worm  1001 PKLEPELERMIDFLVEITEKISVPAIKTDIWKLYQARMKQNVKEECIRQRFMSKLAPIIHRLDNY 1065

  Fly   614 SHNK--------SLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAP 670
            |...        |:.:|:..|.|:.     .|:..|:.|::|.
Worm  1066 SIEARVRIIFVLSVKVDADFLKELR-----KNAVVRVDDEQLI---------------------- 1103

  Fly   671 SPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLV------------DFAMLSASASGTPNGSGS 723
              .:.::.|.||.....:..:...||.||.|..|:            |......|.||:.|
Worm  1104 --TKYVSCNDGGLKLEGNHSMSDRLKNRKRSLDLIKDVDCEKKEAEHDVKKTKKSTSGSEN---- 1162

  Fly   724 SNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKS 788
                         ..|:...|.|.:.           ||.|..|..:..:..     |::|..:.
Worm  1163 -------------DTDAEETDFHSIT-----------ERQPKVVENSENRKR-----ASSAKRRL 1198

  Fly   789 TASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPS 853
            ..|:..::..:.||.:|. |.|:|.:      .:....|::.|.:||:.|::..|.   .:..||
Worm  1199 VTSSSEESDQDDRSSRSK-TEKQRKI------AANEKRSSTASRVRILSDSSDESN---REEGPS 1253

  Fly   854 SLCSLKQQRRGGAAKQKVSAAKDLV-----------QLQSPAGSYPPPGVFEPSVELEIQIPLSK 907
            ...|.|..:..|..|......|.|:           :...|:....|                 |
Worm  1254 CSNSKKLTKISGNKKNPAILRKRLLGDSSDKSDKDERTSCPSSKKRP-----------------K 1301

  Fly   908 LNESVITKAEVESP--LLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVR 970
            |.|:   |.....|  .||..::|.|..::.|          ..|.    :|::|:       |:
Worm  1302 LAEN---KKNASQPKRCLSGSNVKSDKNEKAG----------CSGT----KKQEKV-------VK 1342

  Fly   971 RKKRKVSVEQQTTAVIDEHEPEFDPDD------------------EPLQSLR-ETRSSNNVN--- 1013
            .||:..:.:........:|. ..:.||                  .|:.|:: |.||:.:::
Worm  1343 NKKKPPTPKANENTTTSDHS-RIETDDIQFEGVYPIEPCAPVSSGMPILSVKTEPRSTEHLSFSY 1406

  Fly  1014 -------------VQAAPNPP------------------LDCERVPQAGEARETFVART--NQKA 1045
                         ..|.|.|.                  |.||.:.:.....:| ::.|  ::|.
Worm  1407 ENVAYTQAEFSSTTYACPEPTETISLHDFLTLLRRLLILLQCEELAELARNIKT-ISETGGDEKI 1470

  Fly  1046 PRLSV-----VALERLQR 1058
            |...:     ||..::||
Worm  1471 PTNRINSVLDVAFYKIQR 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795
		SET	1392..1512	CDD:214614
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
set-5	NP_001256612.1	SET	36..151	CDD:214614
		PHA03309	<793..1008	CDD:165564	38/246 (15%)
		SPK	1006..1118	CDD:214732	19/140 (14%)
		PTZ00108	<1115..1328	CDD:240271	52/275 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030