Protein Alignment ash1 and set-21

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_500555.2
• Gene: set-21 / 177204
• WormBaseID: WBGene00021282
• Length: 568
• Species: Caenorhabditis elegans
• Alignment Length: 573
• Identity: 110/573 - (19%)
• Similarity: 200/573 - (34%)
• Gaps: 166/573 - (28%)

  Fly  1085 PPKSEPEIRPAKKR--GRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKR 1147
            |..:|.....|:||  |....:....|||      :|::|.   :|||.. |.:..:     ::.
 Worm     2 PVDAEKLKSKAQKRSIGENDDKSSNAEPP------RKRSKA---MRLPTD-DEDAKY-----VET 51

  Fly  1148 RKNLEAGTQPKKEKPVQPVTVE-EIPP---EIPV----SQEEIDA----------EAEAKRLDSI 1194
            ::.|:..:..|..:.::.:... :.||   |:||    |..::.:          .:|..|::..
 Worm    52 KRALKKYSADKTSEMLRVIKFAFKAPPFKLELPVYLRYSSYQLSSYRDRCQLLKDNSELTRINVE 116

  Fly  1195 P-----TEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSL 1254
            |     ..|..|......:|....|....| :|:|.....:|.:::    .:|....:|:..:.|
 Worm   117 PNIITLNAHLNLLERIRDDPELNTYYEYQE-TENKDLGRCMRFIAQ----RIVMARTNNNLMKHL 176

  Fly  1255 MPPPAKVNKKPGLEEQVGPASLL-------PP------------------PPYCE---KYLRRTE 1291
            :       .:.|...::.|.||.       ||                  |.|.:   :.|...|
 Worm   177 L-------AEQGTSTEITPESLQEYFPAYEPPKNRIRIKSNLTFNENDVIPVYSDLEGETLESLE 234

  Fly  1292 MDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAE--------SVRPNLAGFDHPTCNC-- 1346
            :...|.||    ||:..:..:...|:.....|.:....|        |.:|.:..:::..|.|
 Worm   235 IPVTLTYD----YTDVNMVDQFTEPNLTKAIIMSEENGENMIRCTCCSSKPIVPCYENEKCPCFI 295

  Fly  1347 ---KNQGEKSCLDNCLNRMVYTECSP-------------------SNCPAGEKCRNQK------- 1382
               :.||.:...:.| .:..:|...|                   ..|..|.||.|..
 Worm   296 MNQRMQGFQIPREGC-GKTEFTSFKPIYFFNPKDHYYDHAGFACSELCGCGGKCTNNSMLLPHKK 359

  Fly  1383 ---IQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEK----------------- 1427
               ::.:...|.|        |:.||:.:.|..||.::|:.||:|..|
 Worm   360 LFPLEIYRNDPAV--------GFVVRSTVMIPAGTPLMEFTGEIVELKNMELDNRDYAYQITYSD 416

  Fly  1428 --EFKQRMASIYLNDTHHYCLH--LDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLS--- 1485
              :|::.:..:..:..:...|.  ......||.:..|:..|.|.|:|.||.|:.:.....||
 Worm   417 DVKFRRLLQEVKFSKEYTKLLEKLSRKRFFIDPKIHGNVARTVGHACAPNMEVVRVFQKSLSPAH 481

  Fly  1486 -RMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVK 1537
             .:||.....:.....||.||..:..:..:.: |||.|..||     :.:.||
 Worm   482 LHLVLVTLEDVFPSVPLTIDYGKTYTDVLKDR-CRCRTFACR-----RGEHVK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	43/245 (18%)
		AWS	1340..1388	CDD:197795	12/81 (15%)
		SET_ASH1L	1391..1531	CDD:380951	38/164 (23%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
set-21	NP_500555.2	SET	<336..503	CDD:394802	37/174 (21%)