DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ash1 and set-23

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_741320.1	Gene:	set-23 / 176969	WormBaseID:	WBGene00021515	Length:	244	Species:	Caenorhabditis elegans

Alignment Length:	247	Identity:	81/247 - (32%)
Similarity:	113/247 - (45%)	Gaps:	54/247 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1319 NYRKIRTNVYAESVRPNLAGFD----HPTCNCKNQGEK----SCLDNCLNRMVYT---------- 1365
            ||.||.:.:..    |.::..|    ...|||:.:...    |||.|.::.  ||
Worm     2 NYEKIDSTIPG----PGISETDWNDVFEGCNCEAECSSAAGCSCLINKIDN--YTVDGKINKSSE 60

  Fly  1366 ---ECSPSNCPA---GEKCRNQKIQRHAVAP--GVERFMTAD--KGWGVRTKLPIAKGTYILEYV 1420
               ||| ..|..   ...|||:.:|   ..|  .:|.|.|.:  ||:|||....||.|.::.||.
Worm    61 LLIECS-DQCACILLPTSCRNRVVQ---CGPQKKLEIFSTCEMAKGFGVRAGEQIAAGEFVCEYA 121

  Fly  1421 GEVVTEKEFKQRMASIYLNDTHHYCLHLD---GG----LVIDGQRMGSDCRFVNHSCEPNCEMQK 1478
            ||.:.|:|.::|......:|  :|.|.|.   ||    ..:|.:..|:..||:|||||||||:
Worm   122 GECIGEQEVERRCREFRGDD--NYTLTLKEFFGGKPVKTFVDPRLRGNIGRFLNHSCEPNCEI-- 182

  Fly  1479 WSVNGLSRMV----LFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
             .:..|.||:    :||||.|..||||.|||..|.......:.|.|.:.:||
Worm   183 -ILARLGRMIPAAGIFAKRDIVRGEELCYDYGHSAIEGENRKLCLCKSEKCR 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	18/71 (25%)
		SET	1392..1512	CDD:214614	53/132 (40%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
set-23	NP_741320.1	Pre-SET	<6..81	CDD:282838	18/81 (22%)
set-23	NP_741320.1	SET	89..213	CDD:214614	51/128 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910