DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and Ezh2

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001396739.1 Gene:Ezh2 / 14056 MGIID:107940 Length:751 Species:Mus musculus


Alignment Length:622 Identity:141/622 - (22%)
Similarity:213/622 - (34%) Gaps:212/622 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   971 RKKRKVSVEQQTTAVIDEHEPEFDPD-DEP-LQSLRETRSSNNVNVQAAPNPPLDCER------- 1026
            ::|.|...|||....:   .||..|: |.| .:|::..:|.::.:.       |.|.|       
Mouse   241 KEKYKELTEQQLPGAL---PPECTPNIDGPNAKSVQREQSLHSFHT-------LFCRRCFKYDCF 295

  Fly  1027 -----------VPQAGEARETFVARTNQK-APR-----------LSVVALERLQRPQTPARGRPR 1068
                       .|...:.:.|..|..|:. .|:           .:.:..||::.|.....||.|
Mouse   296 LHRKCSYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR 360

  Fly  1069 GRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGI 1133
            ||.|.|    .:.|..|..|..|          .|....:....|....:..:|.|...:.....
Mouse   361 GRLPNN----SSRPSTPTISVLE----------SKDTDSDREAGTETGGENNDKEEEEKKDETSS 411

  Fly  1134 DPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEH 1198
            ....|..|:..:|.:.|:|                   |||   :.|...|||...|: .|.|.:
Mouse   412 SSEANSRCQTPIKMKPNIE-------------------PPE---NVEWSGAEASMFRV-LIGTYY 453

  Fly  1199 DPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNK 1263
            |...|                             ::::..|.....::....|:|.:..|.    
Mouse   454 DNFCA-----------------------------IARLIGTKTCRQVYEFRVKESSIIAPV---- 485

  Fly  1264 KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIR---- 1324
                     |...:..||..:|...|          :|.|:.               |||:    
Mouse   486 ---------PTEDVDTPPRKKKRKHR----------LWAAHC---------------RKIQLKKD 516

  Fly  1325 ---TNVYAESVRPNLAGFDHP------TCNC---KNQGEK--SCLDNCLNR-------------- 1361
               .:||      |....|||      :|.|   :|..||  .|...|.||              
Mouse   517 GSSNHVY------NYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQ 575

  Fly  1362 ----MVYTECSPS---NCPAGE-------KCRNQKIQRHA-----VAPGVERFMTAD-KGWGVRT 1406
                :...||.|.   .|.|.:       .|:|..|||.:     :||       :| .|||:..
Mouse   576 CPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAP-------SDVAGWGIFI 633

  Fly  1407 KLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCE 1471
            |.|:.|..:|.||.||::::.| ..|...:|......:..:|:...|:|..|.|:..||.|||..
Mouse   634 KDPVQKNEFISEYCGEIISQDE-ADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVN 697

  Fly  1472 PNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFS 1508
            |||..:...|||..|:.:||||||:.||||.:||.:|
Mouse   698 PNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 48/292 (16%)
AWS 1340..1388 CDD:197795 22/91 (24%)
SET_ASH1L 1391..1531 CDD:380951 45/119 (38%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Ezh2NP_001396739.1 Interaction with EED 39..68
EZH2_WD-Binding 39..68 CDD:463308
PRC2_HTH_1 158..249 CDD:436286 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..217
Interaction with CDYL. /evidence=ECO:0000250 334..527 52/302 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..431 23/118 (19%)
preSET_CXC 564..595 CDD:408079 4/30 (13%)
SET_EZH2 614..733 CDD:380995 46/126 (37%)
Blue background indicates that the domain is not in the aligned region.

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