Protein Alignment ash1 and NSD

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_316738.6
• Gene: NSD / 1277307
• VectorBaseID: AGAMI1_000310
• Length: 1323
• Species: Anopheles gambiae
• Alignment Length: 1549
• Identity: 320/1549 - (20%)
• Similarity: 536/1549 - (34%)
• Gaps: 467/1549 - (30%)

  Fly   158 AIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTL 222
            |:||..:|..|.|.|   ::||.....||   :....:::::|..:.:..:.|...|.
Mosquito    25 AVIQRHKSMKKNTKD---TASDRSFTRLV---LTSSGNNSKETKAQENLLETAAATNF------- 76

  Fly   223 LQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINES 287
                  :|.:|..|..     :|..|::|.|      |:.     :|:....|.   ||..:|||
Mosquito    77 ------ETDLLSPTTT-----QKRVKSQEST------PQS-----QKIAKQEPM---SGSEMNES 116

  Fly   288 ADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSK 352
            ......|     ......|..:|.|.|            .::...||.|::
Mosquito   117 GKENAFS-----DQIRNHPTDENSNTV------------VRVPGRYLLKQL-------------- 150

  Fly   353 RRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVS 417
                      |||      |.|...||:::...|                             ||
Mosquito   151 ----------SSS------LSPKMTEINIDTDRR-----------------------------VS 170

  Fly   418 DYGSVRHQRSSHNHNSGY------KSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRM 476
            .||  |||:  ...||.|      |...|..|::.||               |:..:.......:
Mosquito   171 RYG--RHQK--QKDNSDYVPVDLMKYVGSTPSKFKTK---------------SETDDPNSVNKTL 216

  Fly   477 RRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRY 541
            ..|..:|..|::.::|......::.|..:        ....:.:|..|.|.:....|..|....|
Mosquito   217 ETKPHSSDELRTGSNDISLSLTVVPLPLI--------DGSIMKRPEEKQLLSMEEIKIVGMEEPY 273

  Fly   542 VTTGQYFGRGGSLSATNPDN--FISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRM 604
                 |..:|.       ||  |::.::.:        |:|....|.:.|:..:...|.:| :..
Mosquito   274 -----YTDKGS-------DNNCFMNNLLER--------KTSSDADSGKGSSVDLAIIYRAG-NLY 317

  Fly   605 RRRHRRKSFSHNKSLNID------SKLLTE--IEIITSTFNSRCRIQ-------------DDRLT 648
            .....|||......:::|      ::|..:  :|:..|.|..|.|..             |:..|
Mosquito   318 WAAQTRKSIHWPCIVHVDPETDQITRLYGDKFLEVHVSYFGDRGRRAWIKEHSILPFEGVDEYCT 382

  Fly   649 GSSGKE--KLLADANKLQATLAAPSPAQQ-LTLNGGGPASTLSKPLKRGLKKRKL--SEPLVDFA 708
            .:...|  |||..|.|.:....|.|.|:: :||......::....:|..|.:.|:  ....::..
Mosquito   383 NAKNMEYGKLLKSALKSERWKNACSIAERYMTLALSERIASFDHEVKLELARHKVMRHRMAIEGR 447

  Fly   709 MLSASASGTPNGSGSSNGNT-KRRHKKSQSNDSSSPD---------------------------- 744
            :.:.::...|....|.|... :..:|:.:|:...||:
Mosquito   448 IKNGASQKMPALLPSDNSEVLEHWNKRDRSSSPESPEYELLPGVFPTKNNPIKKIKFSPSMQNCI 512

  Fly   745 --DHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSAL 807
              |::.||.:..:.:...|.||.....|||            ...:|.........|:......|
Mosquito   513 LNDNRSPLDRPLHSMDSEENPPGSATKANG------------PKATTLGVSDLENLNSTEYDDIL 565

  Fly   808 TPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGG----AAK 868
            |..:.::.:..||..              |:       |.|.:....:|:||:....|    ..:
Mosquito   566 TFIRYYMFDGHTSYE--------------VE-------KGLQLYVRGICNLKKHSNRGTERTVGR 609

  Fly   869 QKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTK 933
            |::.|.:.         ||...|: |||.|:           |...|.....|::         |
Mosquito   610 QRMHALRK---------SYEILGI-EPSAEV-----------STSLKTRNAHPVI---------K 644

  Fly   934 KEVGQRVVETLLHKTGGNLLLKRKRKKINRTGF-------PTVRRKKRKVSVEQQTTAVIDEHEP 991
            || .:.:.|..:.:...|.|:|...|     ||       |....|..|.::......:.:
Mosquito   645 KE-PKTLEEKFIFELDKNFLMKGVPK-----GFVCYICNRPNNVTKCSKCTLHLHLVCLAN---- 699

  Fly   992 EFDPDD-EPLQSLRETRSSNNVNVQAAPNPPLDCER-----------------VPQ--------- 1029
              ||:: ..:|.|.:.:.             |.||:                 :|:
Mosquito   700 --DPEEVVKMQELVDQKK-------------LCCEKCSTTSIVEKTCFICNDEIPEKSNEQIYRC 749

  Fly  1030 -AGEARETFVARTNQKAPRLSVVALERLQRP----QTPARGRPRGRKPKNREQAEAAPQPPPKSE 1089
             .|:..:.:.....|..|::..|:...:..|    .|.....||......:.......:.|....
Mosquito   750 VVGKCTQAYHISCLQLFPQVRQVSASTIICPYHTCHTCVASEPRSTASMVKTTLAHCLKCPTSYH 814

  Fly  1090 PEIRPAKKRGR-QPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEA 1153
            |.       |. .|...||........|   |:.:|.       |..|.|: |.|..|....:..
Mosquito   815 PS-------GNCIPAGSVLLTTTQLICP---KHTLEQ-------IPLNVNW-CFICGKGGNLICC 861

  Fly  1154 GTQPKKEKPVQPVTVEEIPPE------------IPVSQEEIDAEAEAKRLDSIPTEHDPLPASES 1206
            .|.|   ....||.::..||:            :|:..|.:.|:..:.|.....|    ||.||.
Mosquito   862 ETCP---LACHPVCLQFTPPDEKYFCEGCESGRLPLYNEIVIAKMGSFRWWPALT----LPPSEI 919

  Fly  1207 HNPGPQDYASCSESSEDKA----STTSLRKLSKVKKTYLV------------AGLFSNHYKQSLM 1255
                ||:.........|..    :|..:..|:: |:.||.            :|...:...:|.|
Mosquito   920 ----PQNMLQLRHKPSDICVKFFNTHDMSWLNR-KRMYLYQREDSESLDGSQSGSSMDKRYRSAM 979

  Fly  1256 PPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNY 1320
            ...:|:.|.....:.:||::.|                         :|:.:       ||.  |
Mosquito   980 TEASKIFKILQTRKMLGPSASL-------------------------SYSKA-------VPV--Y 1010

  Fly  1321 RKIRTNVYAESVRP-----NLAGFDHPTCNCKNQGEKSC--LDNCLNRMVYTECSPSNCPAGEKC 1378
            :||:||.|...::|     .|.|.:...|.|:...:..|  ...||||.:..|||...|||.|.|
Mosquito  1011 KKIKTNRYIPPLKPPSVNRQLDGVEDSVCRCQPSDDDPCGPTSACLNRAIMMECSSKTCPAKESC 1075

  Fly  1379 RNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIY-LNDTH 1442
            .||:..:. :.|.:|....:|||:|:.....:..|.:::||||||:..:||.:|:..:. ..:|:
Mosquito  1076 SNQRFTKR-IYPALEVRFFSDKGFGLVALEDLKSGQFVIEYVGEVINSEEFDRRVMMMQAAKETN 1139

  Fly  1443 HYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMV-LFAKRAIEEGEELTYDYN 1506
            :|.|.::..|.||....|:..||:|||||||||.|||:: |.:|:: |||.:.|..|||||::||
Mosquito  1140 YYFLTVEPDLTIDAGPKGNVSRFINHSCEPNCETQKWTI-GETRVIGLFAIKDINAGEELTFNYN 1203

  Fly  1507 F-SLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQR 1559
            . ||.|  ..:.|.|...:|.|.||.|.:.......|.:..|...|  :||::|
Mosquito  1204 LESLGN--NKRVCLCGAGKCSGFIGEKYRPPNKKDIVISMKSERSL--KNGKKR 1253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	58/322 (18%)
		AWS	1340..1388	CDD:197795	17/49 (35%)
		SET_ASH1L	1391..1531	CDD:380951	57/142 (40%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
NSD	XP_316738.6	None