Protein Alignment ash1 and G9a

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_061503609.1
• Gene: G9a / 1272941
• VectorBaseID: AGAMI1_015044
• Length: 2191
• Species: Anopheles gambiae
• Alignment Length: 1869
• Identity: 369/1869 - (19%)
• Similarity: 599/1869 - (32%)
• Gaps: 573/1869 - (30%)

  Fly     6 NETAAA---KVLETQRAQESGSENEETDSITDQSSQ-----SKSIK-------SATQFSVQRSDT 55
            :|..||   |..|.:...::||.|..|:...|::.|     ::|.|       :||..:...|.|
Mosquito   543 DEAMAAEDRKPAEHEAHSDAGSANTSTEDGADKTKQPAGRTTRSKKGAAVVATAATAVASATSTT 607

  Fly    56 DGLRMRISAIRPTLGVVATKKP-------PKSRKMSTQDTESGCSEAKNRAV--SKKVKVKRKKL 111
            ...|......:.:.|.....||       |.:..:..::.:.|.:..|..:|  :.:.|||
Mosquito   608 LSQRRSQRFQKESAGAAGDGKPNGDVASEPSTIVVKEEEVDDGATAKKRASVGPASEAKVK---- 668

  Fly   112 ASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLK--VHQQRAPRVLLSAIIQAAQSASKPTLDIG 174
                |..|||:..:||:       ..:...||.:  |..:||.    ..:..||..|::|.
Mosquito   669 ----GTLKSDRSLRSKQ-------QGNAGTLPAQPTVMTRRAS----ETVKPAADEANEPL---- 714

  Fly   175 ISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNA 239
                                 ||.:|..:.|.......|.|.|          |::.....||.:
Mosquito   715 ---------------------DTVETGADKSIVGRRGRKRLSQ----------ERSVPAAATVVS 748

  Fly   240 KLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVP---APGNSGPAINESADSG----VISTTS 297
            .  |..|.:|:|         :..|..|.|||....   |..:..||..|.:|:|    |.:|.:
Mosquito   749 N--EPPVIRARE---------KPARDEPAKVVEAAEQRRASRSGFPAETEESDAGGKVTVAATPA 802

  Fly   298 TTQSTTPSPKM------QNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQN 356
            ..:.:||..::      :.:|.....:.|..::|.|....|     ..|.:..|:|..|:.|
Mosquito   803 QQEKSTPQQQVPQRRGRKRKNPSTAEATPPTATSTPSGPGA-----ASADKAPLHPYKRAAR--- 859

  Fly   357 NKKTACSSSNKEELQLDPLWREIDVNKKFRL-RSMSVGAASGTGASTTICSKVLA---AKSGYVS 417
                 .|....:.:....|.|...|:.:.|| |.:.:.|            |:||   .:.|:
Mosquito   860 -----VSRDGSDGILASALARRDKVDSQGRLSRPIKLSA------------KILANEELRQGF-- 905

  Fly   418 DYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRA 482
                       ..||:|             :..:.....:.:.....|...|| |.:...::|:
Mosquito   906 -----------EQHNNG-------------RIIIGSEQSSPAVVVHEDELPSG-SVVEAEKQRK- 944

  Fly   483 SMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQ- 546
                  .|.|.||..   ..:..::|.|||:    ::..|:...||...:.......|.:...|
Mosquito   945 ------PARDVVEHS---VASSSTIGSSSED----VTLVSVTMPPTVKPASSGTSSTRRLPPSQE 996

  Fly   547 -YFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASM----C---SSYVSGVSR 603
             ....|.|.....|        ::|...|:|:......|:|...||..    |   .:::.||..
Mosquito   997 KESEAGPSAQPQQP--------SRRPAEPSPADRLAASKARARQAAKANAPPCPDVDTFLQGVRA 1053

  Fly   604 MRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLA 668
            ||..      :.|:|...|::.|.             |.|..|    :.|.||     |..|.|.
Mosquito  1054 MRLG------TANRSRTDDNRKLN-------------RRQQKR----ADKMKL-----KFMAGLG 1090

  Fly   669 APSPAQQLTLNG-----------------GGPASTLSKPLKRG--------LKKRK----LSEPL 704
            ...|:.|...||                 .|..:....|.|.|        |:.||    |..|.
Mosquito  1091 LQRPSAQQPRNGTDGDDFDVQMSVGESDSSGSEADFVPPQKIGTVGRPNVTLRLRKPETLLENPP 1155

  Fly   705 VDFAMLSASASG---------TPNG------SGSSNGNTK-----RRHKKSQSNDSSSPDDHKLP 749
            ...::  |||:|         .|:|      |.:.|.|.:     .|....|||...:|......
Mosquito  1156 RKASL--ASAAGPANRVPLVTAPSGPVGMPKSSAVNANRQAANAHARQVGKQSNGGRTPLAPANG 1218

  Fly   750 LKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHL 814
            ..|.....:|....||.|.    .|.|.:.|:...|..:||.:||.|   |..:|...|.:.:..
Mosquito  1219 AGKSRSSASPAVILPATVT----TLGARSSASKTVAGSTTAGSKSTA---ATLLKDRETEQFKRS 1276

  Fly   815 LEQ--------PTS----VSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAA 867
            |::        ||:    .....|.|:..|.|.....|:....::.|.:|:  ...:||::...:
Mosquito  1277 LQRLGCEITLIPTTGRADSRAVPSPAAPGPSRSGPATNAWPVRRVKDTAPA--VGQQQQQQRPRS 1339

  Fly   868 KQKVSAAKDLVQLQSPA---------GSYPP----PGVFEPSVELEIQIPLSKLNESVITKAEVE 919
            :|.|:....|....||:         ||..|    .|:...|....:....|..::|::.....:
Mosquito  1340 QQNVATPPILPGTTSPSLQIMLGGGPGSGQPVRTTSGLVASSTRTAVPENESCASDSLVCHCRQK 1404

  Fly   920 SPLLSALDIKEDTKKEV----GQRV------VETLLH------KTGGNLLLKRKRKKINRTG--- 965
            |.:..|..:.......|    ||::      ...||:      :....||....||::...|
Mosquito  1405 SDIFVAKTVGNGYCTAVDDIDGQQIGCCNELSNDLLNMLRPSARVSFQLLCNMHRKRLEDHGCCA 1469

  Fly   966 ----FPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCER 1026
                |.|            |....:.::...|.|......:|....:.......|||...|.|..
Mosquito  1470 ICGWFCT------------QGNFAMCKNAHLFHPKCADKYTLNTPYNPARPGDHAAPTLVLKCPH 1522

  Fly  1027 VPQA---GEARETFVARTNQKA---PRLSVVALERLQRPQTPARGR--------PRGRKPKNREQ 1077
            ..|.   ||. |..:..|:...   .|.|:|...::...:|.:.|.        |...|...|..
Mosquito  1523 CNQECPNGEI-EVNIQLTSPPVLLPSRKSMVKPAKMTVSKTGSGGSSSTNGISGPSNGKDSFRTT 1586

  Fly  1078 AEAAPQPPPKSEPEIRPAKKRG-----------RQPKQPVLEEPPPTPPPQQKKNKMEPNIR--- 1128
            .::......|:......:.|.|           ...:....::...|........|:....:
Mosquito  1587 VQSLVPSSVKNMLATDHSSKNGSGVSASTSASSSASRTSSAKDAGSTAGASSTGTKLRHTAKDFT 1651

  Fly  1129 ---------------LPDGIDPNTNF------------------------SCKIRLKRRKN---- 1150
                           :..|.|..|.|                        .|:.|.....|
Mosquito  1652 NAVCTKKDDALVSEIITSGFDIETRFREYHHGTCLHVVCSYGTPAMAYLIMCRARSVDYLNIFDR 1716

  Fly  1151 ---------------------LEAGTQPKKEKPV------------QPVTVEEIPPEIPVSQEEI 1182
                                 |::|.....:.|.            |..||..|   :..:::.:
Mosquito  1717 ELHTAVMRAVVGSKSDIVKLLLDSGADATLKGPYGMTVLHLAAKQGQHDTVRTI---LECARQRL 1778

  Fly  1183 DAEAEAKRLDSIPTEHDPLPASESHNPGPQ----------DYASCSESSEDKASTTSLR--KLSK 1235
            .|.|....::::........|..:.|...|          |...|     |:.:.|||.  .||.
Mosquito  1779 TARALMAFVNAVDNGRWTALAWAAENRHKQTVEQLISIGADVNVC-----DRLNNTSLHWASLSG 1838

  Fly  1236 VKKT-YLVAGLFSNHYKQS---------------------LMPPPAKVNKKPGLEEQVGPASLLP 1278
            ...| |.:.....|...|:                     |:...|.:|.: ....|:....:|.
Mosquito  1839 CSDTLYRLMTKDCNPNLQNSNGETPLHIACRQGHAEICVVLLAMGASLNVR-NTSNQLPQDIILD 1902

  Fly  1279 PPPYC-------------EKYLRRTEM------------DFELPYDIWWAYTNSKLPTRNVVPSW 1318
            |...|             ...|:.|.:            ..::.|     ||......:..||..
Mosquito  1903 PNSECGNIIAANVKMRNLSNNLKETHIICSDISNGRERHPIQVVY-----YTRGANERQLTVPKL 1962

  Fly  1319 NYRKIRTNV---YAESVRPNLAGFDHPTCNCKNQG----EKSCL----------------DNCLN 1360
            .|  |::||   |..::..:.....  .|:|.:..    :..||                .|.|:
Mosquito  1963 KY--IQSNVQIDYRVTIDTDARNMH--VCSCVDSTCTSMDSECLCSERTWYTNDGRLVNDFNYLD 2023

  Fly  1361 RMVYTECSPSNCPAG-EKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVV 1424
            ..:.|||. ..|... ..|||:.:| |.:...::......|||||||.:||.|||:::|||||::
Mosquito  2024 PPIITECG-DLCDCNLRSCRNRVVQ-HGLDVPLQLCYIPGKGWGVRTMVPIPKGTFLVEYVGEIL 2086

  Fly  1425 TEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLS---- 1485
            .::....|:...||.|       |..|..:|....|:..||.||||.||       |:.:|
Mosquito  2087 PDEAANHRLDDSYLFD-------LGNGYCLDASTYGNVSRFFNHSCRPN-------VSPVSVYYD 2137

  Fly  1486 -------RMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ-PCRCNTPQCR 1526
                   |:.|||.:.|...||:.:||....:...:|. .|||||.:||
Mosquito  2138 HKDQRHPRVALFACQDIGVQEEICFDYGEKFWAVKKGSLACRCNTEKCR 2186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	58/400 (15%)
		AWS	1340..1388	CDD:197795	15/68 (22%)
		SET_ASH1L	1391..1531	CDD:380951	52/148 (35%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
G9a	XP_061503609.1	None