DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and DIDO1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_011526806.1	Gene:	DIDO1 / 11083	HGNCID:	2680	Length:	2276	Species:	Homo sapiens

Alignment Length:	2111	Identity:	373/2111 - (17%)
Similarity:	632/2111 - (29%)	Gaps:	823/2111 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NETAAAKVLETQR-------------AQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDG 57
            ||.|...:..|.:             |:..|:.:.|.|.:.....|.:.               |
Human     9 NEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLEPPPPQQQL---------------G 58

  Fly    58 LRMRISAIRP-------TLGVVATKKPPKSRKMSTQDT--ESGC----------------SEAKN 97
            |.:|.|..:|       ....:|.::..:|..:|.:|:  .:.|                ||.::
Human    59 LSLRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATDAETASEGSVESASETRS 123

  Fly    98 RAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDD-LPLKVHQQR----------- 150
            ...|....||.:. |||..:...|....         :|||:.| |.||..|.|
Human   124 GPQSASTAVKERP-ASSEKVKGGDDHDD---------TSDSDSDGLTLKELQNRLRRKREQEPTE 178

  Fly   151 APRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNL 215
            .|...:.:.::..:....|...:|..:||.     |:..:...:....|   :|...:|.||...
Human   179 RPLKGIQSRLRKKRREEGPAETVGSEASDT-----VEGVLPSKQEPEND---QGVVSQAGKDDRE 235

  Fly   216 PQYQSTLLQDFME---------KTQMLGQTVNA-------------------------------- 239
            .:.:....||..:         |.:..|...||
Human   236 SKLEGKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGIS 300

  Fly   240 ----KLAEEK----------VAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADS 290
                :|.|..          :.:.::||..:||..::.:.||             |.|  :..|.
Human   301 EARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWRP-------------GDA--DGTDC 350

  Fly   291 GVISTTSTTQSTTPSPKMQNENAV-PTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRR 354
            ..|.|.....|.....|.:.|.|. |:|        |.|:             ::..|.|
Human   351 TSIGTIEQKSSEDQGIKGRIEKAANPSG--------KKKL-------------KIFQPGP----- 389

  Fly   355 QNNKKTACSSSNKEELQLDPLWR--EIDVNKKFR----LRSMSVGAASGTGASTTI---CSKVLA 410
                       .....||..||:  ||.|::...    |..:|.......|||..|   |..|..
Human   390 -----------GPVPTQLPVLWQVLEIAVSRSISAFTLLHCISCKVIEAPGASKCIGPGCCHVAQ 443

  Fly   411 AKSGYVSDYGSVRHQRSSHNH-----------------------------------NSGYKSDAS 440
            ..|.|.|:...::|..::...                                   :|.:|..|.
Human   444 PDSVYCSNDCILKHAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAP 508

  Fly   441 CKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGL------RMRRKRRA----SMLLKSSADDTVE 495
            .|...:.|..:...:|:::.|..:.|:.|..|..      .::.::.|    |:|.||:.:|...
Human   509 EKKETTVKKAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKEDRRS 573

  Fly   496 DQDILQLA--------GLSLG----------QSSEESNEYISKPSLKSLPT-------------- 528
            ::....:|        |.::|          :.|..:|...:.|::|..|:
Human   574 EEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWLSA 638

  Fly   529 -------------------TSASKKY-------GEINRYVTTGQYF-----GRGGSLSATNPDNF 562
                               |:||||:       |.:.:.|......     ||.|::||
Human   639 TPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMSA------ 697

  Fly   563 ISKMMNQRKETPAPSKSSCKIKSR-RSSAASMCSSYVSGVSRMRRRHRRKSFSHNK----SLNID 622
                        |||:.:.:|:.. |.|...:....|:....:       ..:.|:    :|:|:
Human   698 ------------APSQPNSQIRQNIRRSLKEILWKRVNDSDDL-------IMTENEVGKIALHIE 743

  Fly   623 SKLLTEIEIITSTFNSRCR-----IQDDRLTGSSGKEKLLADANKLQATLAAPSP----AQQLTL 678
            .::....::..:.:.|:.|     ::|.:..|..  .::|.:...| |.|....|    :::|:.
Human   744 KEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLF--HRVLREEISL-AKLVRLKPEELVSKELST 805

  Fly   679 NGGGPA-------------STLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGS--------G 722
            ....||             |..:.|.:..:...:.|.|:.|......||...|..|        .
Human   806 WKERPARSVMESRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFS 870

  Fly   723 SSNGNTKRRHKK--------------SQSNDSSSPDDHKL-------PLKKRHYLLTPGERPPA- 765
            |...:|..:|:.              ..:.|..:|...||       .||.:|....|...|.:
Human   871 SMLKDTTSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPDSA 935

  Fly   766 ---------EVAFANGKLNAE----------------------------AWAAAAAAAKSTASTK 793
                     |||...|..:|.                            ..|:..:...:|.:..
Human   936 DEVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTTVTVS 1000

  Fly   794 SQAQFNARS------VKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISP 852
            .:....|.|      ..:|..|...|::|....|.....::...|..|:...:|....:.|.:.|
Human  1001 GRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSPDPRYLSVPP 1065

  Fly   853 SSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLN-------- 909
            |...|..:.|.                        ||.|        :..:.||:|:
Human  1066 SPNISTSESRS------------------------PPEG--------DTTLFLSRLSTIWKGFIN 1098

  Fly   910 -ESV---ITKAEVESPLLSALD-IKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTV 969
             :||   :|||   .|:....| :.||         :...:| .||.:..|        |.:..|
Human  1099 MQSVAKFVTKA---YPVSGCFDYLSED---------LPDTIH-IGGRIAPK--------TVWDYV 1142

  Fly   970 RRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSS---------NNVNVQ------AAPN 1019
            .:.|..||.|   ..:|..| |..:.::....||....||         ||.:|:      .:..
Human  1143 GKLKSSVSKE---LCLIRFH-PATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQ 1203

  Fly  1020 PPLDCERVPQAGEARETFVARTNQKAPR----LSVVALERLQRPQTPARGRPRGRKPKNREQAEA 1080
            .|:..:.:|..|...|         :||    |.:|..::::||...........| :.|.|.|.
Human  1204 DPVPSKLLPFEGPGLE---------SPRPNIILGLVICQKIKRPANSGELDKMDEK-RTRLQPEE 1258

  Fly  1081 APQPP-PKSEPEIRPAKKRGRQP----KQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFS 1140
            |..|. ||.....:..||..:.|    ...|...||.:|||
Human  1259 ADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTPPGSPPP------------------------ 1299

  Fly  1141 CKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASE 1205
                                           ||.:|       .....|.|.|:.      ||:
Human  1300 -------------------------------PPPLP-------EPPVLKVLSSLK------PAA- 1319

  Fly  1206 SHNPGPQDYASCSESSEDKASTTSLRKLSKVKKT-----YLVAGLFSNHYKQSLMP----PP--- 1258
               |.|...|:.:.::...||:|:    |...||     :::..||..  |:|..|    ||
Human  1320 ---PSPATAATTAAAASTAASSTA----SSASKTASPLEHILQTLFGK--KKSFDPSAREPPGST 1375

  Fly  1259 AKVNKKPGLEEQVGPASLLPPPPYCEKYLRR----------TEMDFELPYDIWWAYTNSKLPTRN 1313
            |.:.::|....:.|    :|.||..:..:::          .|.:.:.|||
Human  1376 AGLPQEPKTTAEDG----VPAPPLLDPIVQQFGQFSKDKALEEEEDDRPYD-------------- 1422

  Fly  1314 VVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKC 1378
              |...|...|             .||                   .::|            |:.
Human  1423 --PEEEYDPER-------------AFD-------------------TQLV------------ERG 1441

  Fly  1379 RNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHH 1443
            |..:::|...|...||...|                |..|  .|.:.|:      |.:.::|..:
Human  1442 RRHEVERAPEAAAAEREEVA----------------YDPE--DETILEE------AKVTVDDLPN 1482

  Fly  1444 YCLHLDGGLVIDGQRMGSDCR--FVNHSCEPNC--------EMQKWSVNGLSRMVLFAKRAIEEG 1498
                          ||.:|.|  .|....||..        |.|| .:..|::.:...||.:||.
Human  1483 --------------RMCADVRRNSVERPAEPVAGAATPSLVEQQK-MLEELNKQIEEQKRQLEEQ 1532

  Fly  1499 EELTYDY---------NFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGR 1554
            ||.....         :||:.:.....|.:.:.|:..  :..:.|:....|| ...|:.:..:.|
Human  1533 EEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLPKAE--LFQQEQQSADKPA-SLPPASQASNHR 1594

  Fly  1555 NGRQRKQKAKKHAQRQAGKDISSAVAVAKLQPLSEKEKK---LVRQFNTFLVRNFEKIRRCKAKR 1616
            :.||.::.|.:..:.: |:.:|...|......|.|::..   ||.|....:....|.
Human  1595 DPRQARRLATETGEGE-GEPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEP-------- 1650

  Fly  1617 ASDAAATASSPALGT----------------TNGDI---PGRR---PSTP--------------- 1644
            ||...|:...|..|:                |.||.   |.||   |:.|
Human  1651 ASSPWASGEKPPAGSEQDGWKAEPGEGTRPATVGDSSARPARRVLLPTPPCGALQPGFPLQHDGE 1715

  Fly  1645 ----SSPSLAAQISALCS-----PRNIKTRG 1666
                :.|..|:|..||.|     |||:.:.|
Human  1716 RDPFTCPGFASQDKALGSAQYEDPRNLHSAG 1746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	5/47 (11%)
		SET	1392..1512	CDD:214614	28/138 (20%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
DIDO1	XP_011526806.1	TNG2	<160..302	CDD:227367	21/149 (14%)
		PHD_DIDO1_like	266..319	CDD:277109	4/52 (8%)
		TFS2M	708..809	CDD:128786	16/110 (15%)
		SPOC	1093..1199	CDD:285043	29/130 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030