Protein Alignment ash1 and EHMT2

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_006715037.2
• Gene: EHMT2 / 10919
• HGNCID: 14129
• Length: 1395
• Species: Homo sapiens
• Alignment Length: 1541
• Identity: 285/1541 - (18%)
• Similarity: 473/1541 - (30%)
• Gaps: 577/1541 - (37%)

  Fly   259 VPRKR-----RGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTP-------SPKMQNE 311
            :||.|     |||.:...|.....|..||.........::|......|.||       ||
Human   125 LPRGRGLMRARGRGRAAPPGSRGRGRGGPHRGRGRPRSLLSLPRAQASWTPQLSTGLTSP----- 184

  Fly   312 NAVPTGSLPIASSSKPKIDMAYLDKRMY-ATERV---LYPPPRS-----KRRQNNKKTACSSSNK 367
               |...||....:..::....|:|... |||||   |...|||     |...::.:.|..||..
Human   185 ---PVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPA 246

  Fly   368 EELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTI-CSKVLAAKSGYVSDYGSVRHQRSSHNH 431
            ..                   :::||   ..||.|.: .:.::..:|..:...|.:|..|....|
Human   247 SV-------------------TVTVG---DEGADTPVGATPLIGDESENLEGDGDLRGGRILLGH 289

  Fly   432 NSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVED 496
                          :|||..|..|:..||..|:....:|
Human   290 --------------ATKSFPSSPSKGGSCPSRAKMSMTG-------------------------- 314

  Fly   497 QDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDN 561
                  ||.             |.||::||.....|..              |..|:.:|.:
Human   315 ------AGK-------------SPPSVQSLAMRLLSMP--------------GAQGAAAAGS--- 343

  Fly   562 FISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLL 626
                       .|.|:.:|                 ..|..::.|..:..|...|....:..|..
Human   344 -----------EPPPATTS-----------------PEGQPKVHRARKTMSKPGNGQPPVPEKRP 380

  Fly   627 TEIEIITSTFNSRCRIQDD-----RLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPAST 686
            .||:        ..|:.||     ::|....|.:.|.....|...|.:...:.::||..|.|.|.
Human   381 PEIQ--------HFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSL 437

  Fly   687 LSKPLKRGLKKRKLSEPLV--DFAMLSASASGTPNGSGSSNGN----TKRRHKKSQSNDSSSPDD 745
                        :..|.:|  ||::...|.|........|...    |::..::.:..:....::
Human   438 ------------EEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEE 490

  Fly   746 HKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARS----VKSA 806
            .:             |....|        ..|...:...:.:|.:|.:.:|:...|.    ||.:
Human   491 EE-------------EEEEEE--------EEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPS 534

  Fly   807 LTPKKRH--LLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQ 869
            ...:||.  ..::|..|:|.|||..:..:.:                  .|.||:....|..:..
Human   535 RKRRKREPPRAKEPRGVNGVGSSGPSEYMEV------------------PLGSLELPSEGTLSPN 581

  Fly   870 KVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKK 934
            ....:.|...|::..|       ||       ::||        ....:|:|.:..:      .:
Human   582 HAGVSNDTSSLETERG-------FE-------ELPL--------CSCRMEAPKIDRI------SE 618

  Fly   935 EVGQRVVETLLHKTGGNL------LLKRKRKKINRTGFPTVRRKKR---KVSVEQQTTAVIDEH- 989
            ..|.:.:.|  ....|.|      :|||:          |:|...|   .|..|.....::..|
Human   619 RAGHKCMAT--ESVDGELSGCNAAILKRE----------TMRPSSRVALMVLCETHRARMVKHHC 671

  Fly   990 ------------EPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTN 1042
                        ..|..||........:...|....:...|:...|      |.||:|..:.|.:
Human   672 CPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGED------ASEAQEVTIPRGD 730

  Fly  1043 QKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPP----------KSEPEIRPAKK 1097
            ...|                    |.|         .|||.|||          .|:|.   |:.
Human   731 GVTP--------------------PAG---------TAAPAPPPLSQDVPGRADTSQPS---ARM 763

  Fly  1098 RGR-QPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDG---------IDPNTNFSCKIRL----KRR 1148
            ||. :|::      ||..|.....:...|::.||:|         :.|......|..:    :||
Human   764 RGHGEPRR------PPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERR 822

  Fly  1149 KNLEAGTQPK------KEKPVQPV---TVEEIPPEIPVSQEE----------------------- 1181
            |.|.  ..|:      |:..:|.|   .::.:.|.....|:.
Human   823 KKLR--FHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQA 885

  Fly  1182 ------IDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTY 1240
                  :|.:.....::::...|..:........|      |..|.|:..| |.|...:|:....
Human   886 GANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGG------CVYSKEEDGS-TCLHHAAKIGNLE 943

  Fly  1241 LVAGLFS-----------------------NHYK--QSLMPPPAKVNKKPGLEEQV--------- 1271
            :|:.|.|                       .|.:  :.|:...|.|.....:.|::
Human   944 MVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLH 1008

  Fly  1272 -----GPASLL-----------------PPPPYC---EKY---------------LRRTEMD--F 1294
                 |.|::.                 ..|.:.   |.|               ||..|.|  :
Human  1009 WASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAW 1073

  Fly  1295 ELP---YDIWWA-----------------------------YTNSKLPTRNVV-----PSWNYRK 1322
            :|.   .|:|:|                             |.|..:|..|.|     |. :|:.
Human  1074 DLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPE-DYKY 1137

  Fly  1323 IRTNVYAE--SVRPNLAGFDHPTC--NCKNQGEKSCLDNCL--------------------NRM- 1362
            |..|....  ::..|:....|.||  :|.:       .|||                    |::
Human  1138 ISENCETSTMNIDRNITHLQHCTCVDDCSS-------SNCLCGQLSIRCWYDKDGRLLQEFNKIE 1195

  Fly  1363 --VYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVT 1425
              :..||:.: |.....|:|:.:| ..:...::.:.||..|||||....|.:||:|.|||||:::
Human  1196 PPLIFECNQA-CSCWRNCKNRVVQ-SGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS 1258

  Fly  1426 EKEFKQRMASIYLNDTHH-----YCLHLDGGLVIDGQRMGSDCRFVNHSCEPN-CEMQKWSVN-- 1482
            :.|...|....||.|..:     ||        ||.:..|:..||:||.|:|| ..::.:.::
Human  1259 DAEADVREDDSYLFDLDNKDGEVYC--------IDARYYGNISRFINHLCDPNIIPVRVFMLHQD 1315

  Fly  1483 -GLSRMVLFAKRAIEEGEELTYDYNFSLFN-PSEGQPCRCNTPQCR 1526
             ...|:..|:.|.|..||||.:||....:: .|:...|:|.:.:|:
Human  1316 LRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCK 1361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	61/380 (16%)
		AWS	1340..1388	CDD:197795	14/72 (19%)
		SET_ASH1L	1391..1531	CDD:380951	47/146 (32%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
EHMT2	XP_006715037.2	PHA03247	<126..382	CDD:223021	72/389 (19%)
		2A1904	<396..504	CDD:273344	21/140 (15%)
		EHMT_ZBD	598..727	CDD:411018	29/167 (17%)
		ANKYR	806..1072	CDD:440430	38/274 (14%)
		ANK repeat	864..893	CDD:293786	0/28 (0%)
		ANK repeat	928..960	CDD:293786	7/32 (22%)
		ANK repeat	962..993	CDD:293786	4/30 (13%)
		ANK repeat	1002..1033	CDD:293786	2/30 (7%)
		ANK repeat	1035..1066	CDD:293786	4/30 (13%)
		SET_EHMT2	1133..1371	CDD:380931	65/247 (26%)