Protein Alignment ash1 and ash1l

DIOPT Version :9

• Sequence 1: NP_001246834.1
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_031747239.1
• Gene: ash1l / 108645568
• -ID: -
• Length: 2656
• Species: Xenopus tropicalis
• Alignment Length: 2824
• Identity: 692/2824 - (24%)
• Similarity: 1079/2824 - (38%)
• Gaps: 924/2824 - (32%)

  Fly    16 TQRAQESGSENEETDSITDQSSQSKSIKSA---TQFSVQRSDTDGLRMRISAIRPTLG------- 70
            :::|.|...|:|......:|...|.:..||   |....| .||.   .|..|:.|:..
 Frog   122 SRKAAEDSPESECLHRSKEQEKVSVAPNSAPLPTDVHAQ-PDTP---PRPRALGPSSASSVTEKL 182

  Fly    71 --VVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISA 133
              ::||..|.||.|          |..|.:|.:.......|:|.::|....:...:|...:..|.
 Frog   183 AQLIATCPPAKSSK----------SRVKKQANAGPNGTPSKELGAASAYEPASDSTKPPNASTST 237

  Fly   134 FSSDSEDDLPL----------KVHQQRAPRVL---LSAIIQAAQSASKPTLDIGISSSDNELPNL 185
            |.|:.::..|:          |.:|::|...|   |||:.:...|:|.|  ..|:|..:..||
 Frog   238 FCSEDKEKQPVPGRQGNGAIDKGNQRQAQEGLKEKLSAMNELGDSSSTP--QGGVSLGEKGLP-- 298

  Fly   186 VQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAK 250
                         ||.::        :|.||.|.::|  ||     .:|...:|..|:...:...
 Frog   299 -------------DTNLQ--------EKMLPVYCTSL--DF-----RMGGASDASTAKSPFSAVG 335

  Fly   251 EETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTP-SPKMQNENAV 314
            |..|                 |: |||..|..:.:.|.:.....:.|::....| |.:..::
 Frog   336 EGNL-----------------PS-PAPATSVTSFSRSPNGTFPHSPSSSLHLNPVSAECSDQ--- 379

  Fly   315 PTGSLPIASSSKP----------KIDM--------------AYLDK--RMYATERVLYPPPRSKR 353
            ||...|.||.:.|          .:|.              |:.:|  |.:....:..||.:
 Frog   380 PTDKSPFASDNLPGTRGHPTAPHSLDSDTVRSNKRSEEYSGAHSEKMSRTHLPSTLRMPPKQ--- 441

  Fly   354 RQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICS------------ 406
                     .||:|.|..:......:...::.::.||:..||....:|:...|
 Frog   442 ---------PSSHKSEPSVVSFASLLRKQRQLKISSMAGAAAERHFSSSQATSHQAKCLKKRKGK 497

  Fly   407 -----KVLAAKSGYVSDYGSVRHQRS--------------------SHNHNSGYKSDAS------ 440
                 ||::..:|..:..|.:..|.|                    |.:|...:|...|
 Frog   498 KPKWTKVVSKSTGQCAKLGQLPEQESLARGIGRAPLLAHTSKGSIPSASHKPTHKLYESHRTYSS 562

  Fly   441 -CKSR---YSTKSCMS------------------------------------------------- 452
             |.||   :.:|.|.|
 Frog   563 LCASRDLFHKSKKCRSQDMPHLDVPPKWALQISPSKLISSQSKEEPGPPILQPEVEIPPAQVSQS 627

  Fly   453 ------RRSRAK-----------------------------SCGYRSD------------CKESG 470
                  :|.|.:                             .||...|            |.|||
 Frog   628 GQLFPKKRGRPRRQLAPPVLKPPCGLSLAPNESIGVEASGAGCGANMDPFGEEPHRASDQCPESG 692

  Fly   471 KSGLR-------------------MRRKRRASMLLKSSADDTVEDQDILQ-----LAGL---SLG 508
            :..|.                   ::|::..|.:|....:.:.:.|..||     ||..   .||
 Frog   693 RKALNRGNGQLVKTIIRKINKMKTIKRRKLVSQILSGGTEPSAQVQPRLQGSVSSLAATFSSKLG 757

  Fly   509 QS---SEESNEYISK----------------------PSL---------------------KSLP 527
            |.   |::...||.|                      |||                     :.||
 Frog   758 QQINVSKKGTIYIGKRRGRKPKVAPLDCLLAKNSTCPPSLLESLGQPLAASTIQPSAASCAEVLP 822

  Fly   528 TTSA---SKKYGEINRYVTTGQYFGRGGSLS---------------------------------A 556
            :.|:   |...|.::. |::...|....|||                                 .
 Frog   823 SPSSCHLSATSGALSP-VSSDASFVEPSSLSYLHMHSARHNSALQTLAMRKAAKDGRQLSPPTLL 886

  Fly   557 TNPDNFISKMMNQRKETPAPSKSS--------------------------CKIKSRRSSAASMCS 595
            .|....||::.:.::.||:|...|                          |..|.||.|...|..
 Frog   887 PNSPAHISELSSLKEATPSPISESHSDETIPSDSGIGTDNNSTSDRAEKLCGQKRRRHSFEHMPL 951

  Fly   596 SYVSG---VSRMRRRHRRKS-------FSHNK---------------SLNIDSKLLTEIEIITST 635
            ..|..   :|.::.:|:.|.       .|::|               .::.|...|.|:|.:..
 Frog   952 MPVEPSVLLSSLKEKHKHKCKHRGHDFLSYDKIKRQKRKRKKKYPQLRVHQDPDFLAELEELIG- 1015

  Fly   636 FNSRCRIQDDRLTGSSG---KEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKK 697
                 |:.|.|:|..:.   ...||....:|........|...|.     |...:.||   .|||
 Frog  1016 -----RLSDVRITHRTHHFIPRDLLPTIFRLNFNNFYSHPTFPLE-----PLHYIRKP---NLKK 1067

  Fly   698 R-----KLSEPLVDFAM---LSASASGT------------------PNG---------------- 720
            :     ||.|.:.:...   |....|||                  |.|
 Frog  1068 KRGRPPKLRETIGEMPFMHSLGFPLSGTGFYPSYGMPYSPSPLTPPPIGLSYYGRYPPTIYPPPP 1132

  Fly   721 ----------------SGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHY-------LLTPGER 762
                            :|....|..:.|||.          ||| |::..:       ||:.|..
 Frog  1133 SPSFTTPLPPPSYMHHAGHLLLNPAKYHKKK----------HKL-LRQEAFLGTGRAPLLSMGTY 1186

  Fly   763 P--PAEVAFA--------------------NGKLNAEAWAAAAAA------------AKSTASTK 793
            |  |.|:|::                    ..:|:.:.....:::            .|.:||.:
 Frog  1187 PSVPPEMAYSWMFEHKHRHRHKHREHRLPDQAQLSIDPLTGVSSSRSVLESLKRYRFGKDSASDR 1251

  Fly   794 SQAQFNAR--------SVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDI 850
            .:.:...|        |....|..:..|...:.:..:.:.|...:|||:|...::| .|..:...
 Frog  1252 YKHKDKHRCHLACPHLSPSQGLLSRDEHWARRDSPETHSLSLGLHSPLQIDCSDSS-PGRSIGGF 1315

  Fly   851 SPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSK--LNESVI 913
            :|||              ::.|:.:......|..|:..|.|        .:..|:.:  |||:
 Frog  1316 TPSS--------------EQASSDEHTNLFTSAIGNCRPSG--------SVSGPVGRKALNEN-- 1356

  Fly   914 TKAEVESPLLSALDIKEDTKKE-VGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVS 977
                  ||......:....:|| ...|:.:.|      ::..:|..::.:|:.....||:
 Frog  1357 ------SPFFMDSTLSRSLRKEPPSDRLAQAL------SVPQERSLRQSDRSSCSPSRRR----- 1404

  Fly   978 VEQQTTAVIDEHEPEFDPDDEPLQSL-----RETRSSNNVNVQAAPNPPLDCERVPQAGEARETF 1037
                            .|.:.|..:|     |.||..:                  ...::.|.|
 Frog  1405 ----------------TPSESPSPALMGVGARGTRMGS------------------LGDDSAEPF 1435

  Fly  1038 VART--NQKAPRLSVVALERLQRPQTP----------ARGRPRGRKPKNRE---QAEAAPQPPPK 1087
            |.|.  |:|..     .||:....|.|          :||..|.|..:||.   ..|:...|.|.
 Frog  1436 VQRIVHNEKPD-----TLEKSVGVQCPIGSVPASGGSSRGHSRERSQENRNPTASIESYNGPGPA 1495

  Fly  1088 SEPE-------------------------------------------IRPAKKRGRQ-------- 1101
            |..:                                           |..|||..||
 Frog  1496 SSRQVGSGCSSQQLKRSMVEAIHKRARRMYSYDRILASKKNLDHVNKILKAKKLQRQSRTGNNFV 1560

  Fly  1102 PKQPVLEEPPPTPPPQQKKNKMEPNIR---LPDGIDPNTNFSCKIRLK-----RRKNLEAGTQPK 1158
            .::|  ..|...|....:..::.|.:|   :.|.|:.... |..:|.:     :||:||...|.|
 Frog  1561 KRRP--GRPRKYPVDSLQAAQLFPIMRSDTVTDVIEAVVQ-SVSLRDEQHKGWKRKHLELDKQVK 1622

  Fly  1159 KEKPVQPVTVEEIPPEIPVSQEE-----------IDAEAEAKRLDSIPTEHDPLPASESHNPGPQ 1212
            |    :|.::.|...|..:|..|           |....|.:|...:.....|.|..:...|.|.
 Frog  1623 K----RPKSLYEDDQESNISLSECAIVEAPAAPDISGNPEVERAGDLLHTMAPPPQKQKKAPRPP 1683

  Fly  1213 DYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVN-KKPGL-----EEQV 1271
                                    ||.|..|||||:.|| :|.|....|. ||..|     |.:.
 Frog  1684 ------------------------KKKYQKAGLFSDMYK-TLDPKSRLVQLKKEKLEYDPREHEY 1723

  Fly  1272 GPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNL 1336
            |   |||.|.:..||||:...||:|||||.|.:.:::|..:..||.  |:|||:|||.: |:| |
 Frog  1724 G---LLPAPIHIGKYLRQKRNDFQLPYDILWQWKHNQLYKKPDVPL--YKKIRSNVYVD-VKP-L 1781

  Fly  1337 AGFDHPTCNCK---NQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTA 1398
            :|::...||||   ||.||.|:::|||||::.||||:.||.||:|.||.||||.....:|||...
 Frog  1782 SGYEATMCNCKCPDNQSEKGCVEDCLNRMIFAECSPNTCPCGEQCNNQCIQRHEWVQCLERFRAE 1846

  Fly  1399 DKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDC 1463
            .||||:|||.|:....:|:||:||||:|.||:.|....|.|.:.||||.||.|:|||..|||::.
 Frog  1847 GKGWGIRTKEPLKASQFIIEYLGEVVSETEFRNRTIEQYHNHSDHYCLSLDSGMVIDSYRMGNEA 1911

  Fly  1464 RFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGV 1528
            ||:||||:||||||||||||:.|:.|:|.:.:..|.||||||||..||..:.|.|:|...:|||:
 Frog  1912 RFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNTEKQQVCKCGVEKCRGI 1976

  Fly  1529 IGGKSQRVKPLPAVEAKPSGEGLSG--RNGRQR-KQKAKKHAQRQAG---KDISSAVAVAK---- 1583
            ||||||||..|    |...|..:..  |.||.: |:|:|...:::.|   :|.|.|:....
 Frog  1977 IGGKSQRVNGL----ANKGGHLVPSQRRLGRSKEKRKSKHRLKKRKGHFPEDRSDAIGTPSRLGP 2037

  Fly  1584 ---LQPLSEKEKKLVRQFNTFLVRNFEKIRRCKAKRASDAAATASS----PALGTTNGDIPGRRP 1641
               ::|:|.:|:..|.:.:.|||||:||||: :.:...|.....|.    .::|..:|:|
 Frog  2038 QLHMKPMSNRERNFVLKHHVFLVRNWEKIRQ-RHEEVKDNLPPGSLYSRWSSMGRDDGNI----- 2096

  Fly  1642 STPSSPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLK------MSD 1700
               .|.....|.|||.:.|:::||.|..|..:.|:.:.|::|.:.::|...:...|      ::.
 Frog  2097 ---KSDVFMTQFSALQTSRSVRTRRLAAAEENTEVARAARLAHIFKEISDGIICYKDFSNRPLAS 2158

  Fly  1701 LLTTVSSKKKKPIKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQH 1765
            .|.::.:|||.|..        ....:..::..|::.|:..|||||.:.||..|.::|..|::.|
 Frog  2159 PLLSLPNKKKNPHY--------YEKVSDPLDLLSVEKQILTGHYKTVEAFDTDMLKVFRNAEKYH 2215

  Fly  1766 GDDEGKEKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIAVKKSPGAK 1830
            |......:.:..|:.:|...:..:..|:.||:|::            :||.:..:.::....|..
 Frog  2216 GRKSQVGRDVCRLRKAYYSARHEAAAQIDEIVGET------------ASEADSSETSLFDKDGGH 2268

  Fly  1831 ERDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTECTKADIDADNY 1895
            |:                     |:|:|||||||:|||||||||.|||||||.:|.....|.::|
 Frog  2269 EK---------------------DDDIIRCICGLFKDEGLMIQCEKCMVWQHCDCMGVTSDVEHY 2312

  Fly  1896 QCERCEPREVDREIPL---EEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIKDESGKVLPTK 1957
            .||:|.||.||||:|:   ..:.:.|..|::.|:|.||.:||||.||::||.....:...|
 Frog  2313 LCEQCNPRPVDREVPMIPCPHYAQPGFIYFICLLRDDLLLRQGDCVYLMRDSRRTPDGQPV---- 2373

  Fly  1958 KHTYETIGAIDYQECDIFRVEHLWKNELGKRFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEV 2022
            :.:|..:..|:.::.||||:|.|||||.|:||.||||:.|||||.|.|||:||.||:.||.|||:
 Frog  2374 RQSYRLLSHINREKLDIFRIEKLWKNEKGERFAFGHHYFRPHETHHSPSRKFYYNELFRVPLYEI 2438

  Fly  2023 VPIELVIGRCWVLDRTTFCKGRPMECNDEDHCYICELRVDKTARFFSKAKAN-HPACTKSYAFRK 2086
            :|:|.|:|.|.|||..|:|||||....::| .|||:.|:||:|..|.|...| :..|||:|||..
 Frog  2439 IPLEAVVGTCCVLDLYTYCKGRPKGVKEQD-VYICDYRLDKSAHLFYKIHRNRYTICTKTYAFDH 2502

  Fly  2087 FPEKIKISKSYAPHDV--------------------DPSLLKTRKQ--KTELDVGAGPTTMHKVS 2129
            ||:|:...:.::||.|                    ..|.|.|.:.  .|..|:...|.|.
 Frog  2503 FPKKLTPKRDFSPHHVPDNYKRNGGRSAWKSDRPKQSSSCLHTEEDPLPTMADLLTNPETC---- 2563

  Fly  2130 GRQEQHQAKMVGRKP-------RGISAPADATAVHVVTPVAPNKQMLKKRKSRLENVLITMKLKC 2187
              |:::.|..|....       ..:...:..|..|:.:    .::..:.::.:|..:|    |:.
 Frog  2564 --QQENPAPEVPETESPCLEVNEQVEESSSTTQAHLCS----TQERQQVQRDKLNRIL----LRL 2618

  Fly  2188 LDAQTAQEQPIDLSYLLSGRGAR--QRKT 2214
            || :...:..||::|||.....|  :|:|
 Frog  2619 LD-KIPGKNAIDVTYLLEEGPCRKLRRRT 2646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	29/50 (58%)
		SET	1392..1512	CDD:214614	68/119 (57%)
		Bromo_ASH1	1680..1787	CDD:99955	25/112 (22%)
		PHD_ASH1L	1858..1900	CDD:277023	28/41 (68%)
		BAH_polybromo	1929..2073	CDD:240068	72/143 (50%)
ash1l	XP_031747239.1	PHA03307	25..>408	CDD:223039	76/352 (22%)
		AWS	1785..1836	CDD:197795	29/50 (58%)
		SET_ASH1L	1839..1979	CDD:380951	76/139 (55%)
		Bromo_ASH1	2132..2237	CDD:99955	25/112 (22%)
		PHD_ASH1L	2275..2317	CDD:277023	28/41 (68%)
		BAH_polybromo	2354..2488	CDD:240068	69/138 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	1	1.000	-	-		FOG0007422
OrthoInspector	1	1.000	-	-		oto105202
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010