DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and Kmt2b

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_038949797.1 Gene:Kmt2b / 102550344 RGDID:7678027 Length:2714 Species:Rattus norvegicus


Alignment Length:1101 Identity:224/1101 - (20%)
Similarity:340/1101 - (30%) Gaps:379/1101 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   639 RCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQL----------TLNGG-----GPASTLS 688
            ||||.:.|..|...:...|..|.:.|..:.:|:|:.:.          :|..|     .|...|.
  Rat  1776 RCRILEYRPWGPREEPVHLETAEENQTIVHSPAPSSEPPNHDDLPDTDSLVPGDPVHLSPIQNLD 1840

  Fly   689 KPLK-----------RGLKKRKLSEPL----------VDFAMLSASASGT------PNGSGSSNG 726
            .||:           |.....::..|.          |.|..|.:..|.:      |....|...
  Rat  1841 PPLRTDSSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDSDFP 1905

  Fly   727 NTKRRHKKSQ--------SNDSSSP----DDHKLPLKKRHYLLTPGERPPAEVA----------- 768
            ...||.::..        |..:|||    ...::||.......|.||..|.::|           
  Rat  1906 APPRRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVLTPTSGELAPPDLAPSPLPPSEDLG 1970

  Fly   769 ------------------FANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLL 815
                              ||...|..|.:.....||.:..|::...   ..|.:...:|..|::.
  Rat  1971 PDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSQGGP---GDSSEEEASPTTRYVH 2032

  Fly   816 EQPTSVSG---AGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDL 877
            ...|.|||   |.||.:.:| ||    ..:.|   :|....|.....||.||...          
  Rat  2033 FPVTVVSGPTLASSSLAGAP-RI----EQLDG---VDDGTDSEAEAVQQPRGQGT---------- 2079

  Fly   878 VQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVE 942
                      ||.|   |:|.                    ...:|.|...:....:::...:|:
  Rat  2080 ----------PPSG---PAVG--------------------RGGVLGAAGDRARPPEDLPSEIVD 2111

  Fly   943 TLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETR 1007
            .:|...||                                     ..|....|.::.|.|.    
  Rat  2112 FVLKNLGG-------------------------------------PGEGAAGPREDSLPSA---- 2135

  Fly  1008 SSNNVNVQAAPNPPL-DCERVPQAGEARETFVART---NQKAPRLSVVALERLQRPQTPARGR-- 1066
                        ||| :..:.||:.........||   ...||.:.|::|.....|..||..:  
  Rat  2136 ------------PPLANGSQPPQSLSTNPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKII 2188

  Fly  1067 --PRGRKPKNREQAEAAPQPPPKSEPEIRP-----AKKRGRQPKQPVLE----------EPPPTP 1114
              .:..:...:...|..|..||..:|.:.|     |......|..|:|.          .|.|.|
  Rat  2189 LVNKLGQVFVKMAGEGEPVVPPVKQPSLPPIIPPTAPTSWTLPPGPLLSVLPVVGVGVVRPAPPP 2253

  Fly  1115 PPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQ 1179
            ||        |.:.|.....|.:.....||:||.... :|..|    ||.|      |.:.|...
  Rat  2254 PP--------PPLTLVFSSGPPSPPRQAIRVKRVSTF-SGRSP----PVPP------PNKAPRLD 2299

  Fly  1180 EEIDAEAEAKRLDSI-----------------------PTEHDPLPASESHNPG-PQDYASCSES 1220
            |:.|:..:...:..:                       |.||   |..||  || |||  .|...
  Rat  2300 EDGDSLEDTHHVPGVSGSGLSRVRMKTPTVRGVLDLNNPGEH---PEEES--PGRPQD--RCPLL 2357

  Fly  1221 SEDKASTTSLRKLSKVKKTYLVAGLFSNHY-----KQSLMPPPAKVNKKPGLEEQVGPASLLPPP 1280
            ...:|.:.:|...|.:    |....:.:||     ..|...||:..:|:..:.::.||       
  Rat  2358 PLPEAPSRTLDGPSDL----LFESQWHHHYSAGEASSSEEEPPSPEDKENQVPKRAGP------- 2411

  Fly  1281 PYCEKYLRRTEMDFELPYDIWWAYTNSKLPT------RNVVPSWNYRKIRTNVYAESVRPNLAGF 1339
                 :||     ||:..|..::.....|..      ..|..:..:.::|...::......|.|.
  Rat  2412 -----HLR-----FEISSDDGFSVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGI 2466

  Fly  1340 DHPTC-----------NCKN-------QGE-------------------KSCLDNCLNRMVYTEC 1367
            .|...           :|::       |||                   :.|..:..|   :...
  Rat  2467 HHDAVIFLAEQLPGAQHCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFN---FLAS 2528

  Fly  1368 SPSNCPAGEKCRNQKIQ--------------------RH-----AVAPGVERFMTADKGWGVRTK 1407
            .....|.|..|..::.:                    ||     ..|.||.|  :|..|.|:..|
  Rat  2529 QHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYR--SAIHGRGLFCK 2591

  Fly  1408 LPIAKGTYILEYVGEVV-------TEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRF 1465
            ..|..|..::||.|.|:       .||.:..:....|:       ..:|...|:|....|:..||
  Rat  2592 RNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYM-------FRMDDFDVVDATMHGNAARF 2649

  Fly  1466 VNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            :||||||||..:...|.|...:|:||.|.|..||||||||.|.:.:.|...||.|...:||
  Rat  2650 INHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCR 2710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 12/109 (11%)
SET 1392..1512 CDD:214614 45/126 (36%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Kmt2bXP_038949797.1 zf-CXXC 956..1003 CDD:366873
PHD1_KMT2B 1202..1248 CDD:277064
PHD2_KMT2B 1250..1299 CDD:277066
PHD3_KMT2B 1336..1392 CDD:277068
Bromo_ALL-1 1373..1515 CDD:99925
ePHD_KMT2B 1580..1684 CDD:277164
FYRN 1732..1779 CDD:399155 2/2 (100%)
PHA03247 <1807..2315 CDD:223021 116/633 (18%)
FYRC 2412..2496 CDD:197781 13/88 (15%)
SET_KMT2A_2B 2561..2714 CDD:380947 55/159 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166352038
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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