DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ash1 and LOC101883274

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_021331411.1	Gene:	LOC101883274 / 101883274	-ID:	-	Length:	766	Species:	Danio rerio

Alignment Length:	823	Identity:	156/823 - (18%)
Similarity:	261/823 - (31%)	Gaps:	283/823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   829 SNSPL-RIVVDNNSISGGKLLDISPS-------SLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAG 885
            |.:|| |::.:..  |.|.:::..||       |..|...|..|..|:..:....:.:..:|...
Zfish    64 STNPLARMIAEMQ--SKGLVINNLPSVLPEPARSTTSSVPQSSGEGAESSLEPPNESLSDESSGE 126

  Fly   886 SYPPPG--VFEPSVELEIQIPLSKLNESVITKAEVESPLLSALD--IKEDTKKEVGQRVVETL-- 944
            .|...|  ::..||.:|:      :.:.:..|..::.|||:..:  :..|...:..::||||:
Zfish   127 YYQSTGGPMWTSSVRVEM------VKKGLYNKHSIDHPLLAGFNKYLYTDLGYKNSKQVVETVSR 185

  Fly   945 -LH---KTGGNLLLKRKRKKINR-------------TGFPTVRRKKRKVSVEQQTTAVIDEHEPE 992
             ||   .|..||:..|:.:|:..             |.|...:..||.:.....:|.:...:...
Zfish   186 FLHYMDPTEPNLMFVRRVEKVREYFNILSDTKLSKWTVFNYSKSLKRFMKYIITSTDIRHNNPAL 250

  Fly   993 FDPDDEPLQSLRETRS--SNNVNVQAAPNP----------PLDCERVPQAGEARETFVA------ 1039
            |...:..:.:|...:|  |..|:::.....          |.||..|.:|  |.:.|.|
Zfish   251 FQDCESFMDALYGIQSGMSKEVSMEVTAKKSEFGCGKEVLPKDCLAVLEA--AFKDFQAVICKMQ 313

  Fly  1040 ----------RTNQKAPRL----SVVALERLQRPQTPA-------RGRPR-----------GRKP 1072
                      ..|::...|    :|:.|:.:|||....       .||.|           .:.|
Zfish   314 GPGAITGDCLTKNERLLVLYYLEAVIMLKLVQRPGIVTHMTVEDWEGRSRIENGVCVAVKEHKVP 378

  Fly  1073 KNREQAEAAPQPPPKSE-------PEIRPAKKRGRQPKQPVLEEP-------PPTPPPQQKKNKM 1123
            .:.||           |       .|:||...:..:....|..:.       .....|.....::
Zfish   379 LSHEQ-----------ELWFDLYFNEVRPVMLQENRTGDDVAVDSFFVSSSGRSIYNPSNDLKRL 432

  Fly  1124 EPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEA 1188
            .....||       :.:|.   ..::..||..|                     :..|::....|
Zfish   433 HDKYSLP-------SVTCG---DAQRAFEAAAQ---------------------NLSEVERNVAA 466

  Fly  1189 KRLDSIPTEHDP------LPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFS 1247
            :|.....|..||      |.......|.....|||.|:..|:.:.
Zfish   467 ERNYMRRTSSDPFLALSVLDQLAGKTPQRSSRASCCETRVDEQTA-------------------- 511

  Fly  1248 NHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEM---DFELPYDIWWAYTNSKL 1309
              ||..               ||..|.:|..|||   |..||||:   :.|
Zfish   512 --YKTL---------------EQFCPVTLEGPPP---KRSRRTELCGSEHE-------------- 542

  Fly  1310 PTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPA 1374
              |:....|...:::       :|...| .:|.|   ..|..:|.:...:::..:|    ||.|.
Zfish   543 --RHCYDRWRSEQLK-------LREQHA-LEHFT---GQQPSESKISRWMDKQGWT----SNVPQ 590

  Fly  1375 G-----------------------EKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYI 1416
            .                       :...:|:.:...|.|      ..|||.||.||.|...|..:
Zfish   591 AAVVLKQWKPVARLDLVIDSSFVKKMILSQRWKGLTVRP------VPDKGDGVFTKRPFQIGEVV 649

  Fly  1417 LEYVGEVVTEKEFKQRMAS----------IYLNDTHHYCLHLDGGLVIDGQRMGSDC-------- 1463
            .||.||:|:.:: ...:||          .|.|..|.       .:.||.......|
Zfish   650 CEYHGELVSHED-GMAIASTSSIRAGHLFFYRNKQHE-------AMCIDAHEESCQCHPMKFNYG 706

  Fly  1464 RFVNHSCE-PNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDY 1505
            |.:.||.: .|...:.:.:|....::..|.:.|...|||.|||
Zfish   707 RLIRHSSKRANIRPRLYVLNDRDIILFIATKDISSDEELLYDY 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	9/70 (13%)
		SET	1392..1512	CDD:214614	35/133 (26%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
LOC101883274	XP_021331411.1	SET	625..751	CDD:214614	37/139 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840