DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and kmt2d

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_009295228.1 Gene:kmt2d / 100536523 ZFINID:ZDB-GENE-060223-2 Length:4967 Species:Danio rerio


Alignment Length:1872 Identity:342/1872 - (18%)
Similarity:573/1872 - (30%) Gaps:675/1872 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSCSQNETAAAKVLETQ-RAQESGSENEETDSITDQSSQSKSIKSATQFSVQRSDTDGLRMRIS- 63
            |..:|...|.|..:.|. ..|...::|.:...:|    .|:.::.......||....|..:|:. 
Zfish  3421 MMMTQRPGAPAGQIRTSINIQAFIAQNPQLRHLT----PSQQLQQIQAMLAQRQLQQGQMLRLQG 3481

  Fly    64 --------------AIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASS 114
                          ::.|.:.|:.|::         |....|.:.....:..::..|.|::    
Zfish  3482 QAQGQMRPQVLQGPSVGPRIPVIETQQ---------QQHRFGLAGKHGSSTQQQPGVIRQQ---- 3533

  Fly   115 SGISKSDKVSKSKKSQISAFSSDSEDDLP--------------LKVHQQ-----RAPRVLLSAII 160
            ||::     .:..:..|.|....|:..||              .:|||.     :.||.::..:.
Zfish  3534 SGMA-----PQFHQGVIGAMQQPSQGPLPQYINSAQQQQMIQQQQVHQHQMMRGQVPRPIMGQVR 3593

  Fly   161 QAAQS----ASKPTLDIGISSSDNELPN---LVQAA-----IKRVESDTEDTTVEGSFRKAAK-- 211
            ..|..    ...|...:|..|..:.|.|   ||:.:     .:.::..|..||....|:.:..  
Zfish  3594 NTAPGHLARPMSPRQLLGQGSPGSPLSNQQRLVRMSQTPPGTQHLQQQTHGTTALSPFQASPSHA 3658

  Fly   212 ----DKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTA--------VPRKRR 264
                ..::|:..|..|.........|...:::....|.:. .|.....||.        .|..:.
Zfish  3659 GSPAGSSVPEAGSPSLNKPEPGNMALSSNLSSPSRPEGIV-GKSSPFSQTGGLIPSPLRSPTAKT 3722

  Fly   265 GRPKKVVPTVPAPGNSGP----AINESADSGVISTTSTTQST-TPSP--KMQNENAVPTGSLPIA 322
            ..|.....:.|.|.| ||    |.|::.:||.||...|:|.| .||.  ||..:|.         
Zfish  3723 QSPNTEALSAPFPLN-GPSSQVAQNQAPNSGQISGGHTSQPTQMPSEMCKMTLQNI--------- 3777

  Fly   323 SSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREID------- 380
                                           :|..::..|.:.|..|...|.:.|||.       
Zfish  3778 -------------------------------KQEPREVQCDTGNIVETHSDGIKREISGESVSGS 3811

  Fly   381 --VNKKFRLRSMS--VGA-ASGTGASTTICSKVLAAKSGYVSDYGSVRHQRSS---HNHNSGY-- 435
              ||.....|:.:  :|: ...|.....:..|:|..|:..|:      .||.|   ||..:|:  
Zfish  3812 GIVNSAVGSRNQAGDIGSQIQRTETGQQLLQKLLRTKNLQVA------AQRPSDGIHNEINGHIN 3870

  Fly   436 --------KSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADD 492
                    |...:.::....:|...|....|:       |.:.|:|.|....|:     |:..::
Zfish  3871 NKLAMLEQKLQGTPRNMEDLQSLTKRAPIVKA-------KRTAKAGERGPNSRK-----KTKKEE 3923

  Fly   493 TVEDQDIL-QL-AGLSLGQSSEESNEYISKPSLKSLPTTSAS----KKYGEINRYVTTGQYFGRG 551
            ..:.:.|: || .||||....|              |:.:||    ..:|.......| |..|..
Zfish  3924 VGKTEAIMKQLKQGLSLLPLME--------------PSITASLDLFAPFGSSPANAKT-QLKGSF 3973

  Fly   552 GSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHN 616
            |:....|..::.|:::.:...:..|:..|....:...|......:.|:.|..:....:....|.:
Zfish  3974 GNAILDNIPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQHKLLNGVTQVEELAEGQKETEASED 4038

  Fly   617 ---------KSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSP 672
                     ||::|.:.|.|.    ....|...|::.|            .|::...:.:.|.||
Zfish  4039 TIGSVPEEVKSVDILAALPTP----PHNQNEDIRMESD------------DDSDASDSIVPASSP 4087

  Fly   673 AQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQS 737
            ..||     |..:|         :...|.:|                             |:.:.
Zfish  4088 ESQL-----GDETT---------RFPSLLDP-----------------------------KEEEE 4109

  Fly   738 NDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEA--WAAAAAAAKS-TASTKSQAQFN 799
            ..:.||   .:|:..|..:....|..|.|  ..:||:.|.:  |..|.:...| |....|.|..|
Zfish  4110 ERAISP---VIPIIPRSTIPNFSETKPFE--SVDGKVVASSSQWDKAKSNEVSVTFMLSSAAAKN 4169

  Fly   800 ARSVKSALT-------PKKRHLL--EQPTSVSGAG----SSASNSPLRIVVD-NNSISGGKLLDI 850
            ..:|..|:.       |....|.  :.|..| |||    ..:||..|:.... :|.....|..|:
Zfish  4170 LNTVMLAVAQLLHIRMPSSYELAFPQSPGRV-GAGPGKVPDSSNPGLKTDASVSNDAEWLKQFDV 4233

  Fly   851 S-PSSLCSLKQQ--------RRGGAAKQK------VSAAKDL---------VQLQSPAGSYPPPG 891
            | |.  |:|::|        :.....:.|      ::...||         |::..|....||| 
Zfish  4234 SLPG--CTLRKQVDILALIKQESQEQEDKPAQHCYMTNVSDLDVRHLPVIPVEVSPPPSPSPPP- 4295

  Fly   892 VFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKR 956
              .||                .|.||.|       :..:...|...:..|:|             
Zfish  4296 --PPS----------------STVAEPE-------NTTQPEPKPESEATVQT------------- 4322

  Fly   957 KRKKINRTGFPTVRRK---KRKVSVEQQT-----TAVIDEHEPEF------DPDDEPLQSLRETR 1007
                   |..|:....   |.::.|:|::     |...:.|||..      .|.::|        
Zfish  4323 -------TSSPSASPSAPVKTEILVKQESHCSPVTVEPESHEPAVLPIAVPPPQEQP-------- 4372

  Fly  1008 SSNNVNVQAAP--NPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPR-- 1068
                    :||  :||||...:                   .:|:.:::...||.:....||:  
Zfish  4373 --------SAPASSPPLDSPTI-------------------EISLKSIKHRSRPLSDEEQRPKVK 4410

  Fly  1069 --------------------GRKPKNREQAE--------AAPQPPPKSEPE-------------- 1091
                                .:|..:||.:|        ..|...|:.:.:              
Zfish  4411 KWKGLRWKRLQIVITIRKGGSKKESSREVSELMERLRITLKPDKLPRDKRKCCFCHEEGDGATDG 4475

  Fly  1092 ----------------------------------IRPAKKRGRQPKQPVLEEPPPTPPPQQKKNK 1122
                                              :..|.:||.:.:....::...|    ...|:
Zfish  4476 PARLLNIDVDLWVHLNCALWSTEVYETQGGALINVEVALRRGLRTRCAYCQKTGAT----NSCNR 4536

  Fly  1123 ME-PNIRLPDGIDPNTNFSCKIRLK----RRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEI 1182
            :. ||:         .:|:|.||.:    :.|.:.. ||.|.:.|               |:||:
Zfish  4537 LRCPNV---------YHFACAIRARCMFFKDKTMLC-TQHKLKGP---------------SEEEL 4576

  Fly  1183 DAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFS 1247
            .:.|..:|:                      |.   |..|.|...:.|::..:: ..:.|.||..
Zfish  4577 SSFAVFRRV----------------------YI---ERDEVKQIASILQRGDRI-HLFRVGGLIF 4615

  Fly  1248 NHYKQSLMPPPAKVNKKPGLEEQVGPA------SLLPPPPYCEKYLRRTEMD----FEL------ 1296
             |....|:|....|...|.....||..      |...|...|....|.:|.|    ||:      
Zfish  4616 -HAVGQLLPSQMAVFHSPSAIYPVGYEATRIYWSTRVPNRRCRYRCRISEQDGRPLFEVRVLEHG 4679

  Fly  1297 ----------PYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVR-PNLAGFD-HPTCNCKNQ 1349
                      |..||....:.....|:       ......::.|.|| ..:.|.. |........
Zfish  4680 YEDLHFRDSTPDGIWAKIVHQVAKLRD-------EAAMLKLFTEHVRGEEMYGLTVHAVMRITES 4737

  Fly  1350 --GEKSCLDNCLNRMVYT-------------ECSPSNCPAGEKCRNQKIQRHAVAPGV------- 1392
              |.:||.|       ||             ..:|:.|...|    .||..|...|..       
Zfish  4738 LPGVESCQD-------YTFRYGRHPLMELPLMINPTGCARSE----PKILTHCKRPHTLNSTSMS 4791

  Fly  1393 ---------------------------ERFMTADK-----------GWGVRTKLPIAKGTYILEY 1419
                                       .|..|..|           |.|:.....:.|.|.::||
Zfish  4792 KAYQSTFTGEINTPYSKQFVHSKSSQYRRLKTEWKTNVYLARSRIQGLGLYAAKDLEKHTMVIEY 4856

  Fly  1420 VGEVV-------TEKEFKQRMASIY---LNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNC 1474
            :|.::       .||.::::...||   :|:.|          |||....|...|:|||||.|||
Zfish  4857 IGTIIRNEVANRREKIYEEQNRGIYMFRINNEH----------VIDATLTGGPARYVNHSCAPNC 4911

  Fly  1475 EMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            ..:..:.:...::::.:.|.|.:||||||||.|...:.....||.|....||
Zfish  4912 VAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCR 4963

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 13/63 (21%)
SET 1392..1512 CDD:214614 40/174 (23%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
kmt2dXP_009295228.1 PHD_SF 122..205 CDD:304600
PHD1_KMT2C_like 218..263 CDD:276984
PHD_SF 265..310 CDD:304600
PHD 346..391 CDD:214584
PHD_SF 821..871 CDD:304600
PHD5_KMT2C_like 872..918 CDD:276988
PHD5_KMT2D 949..999 CDD:277074
HMG 1473..1528 CDD:197700
Med15 3305..>3717 CDD:255446 52/318 (16%)
PHD_SF 4462..4568 CDD:304600 14/119 (12%)
FYRN 4612..4662 CDD:283589 12/50 (24%)
FYRC 4668..4749 CDD:283590 16/94 (17%)
SET 4828..4949 CDD:214614 37/130 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.030

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