DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and ezh1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_031750333.1	Gene:	ezh1 / 100493532	XenbaseID:	XB-GENE-1010736	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	765	Identity:	169/765 - (22%)
Similarity:	264/765 - (34%)	Gaps:	206/765 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   878 VQLQSPAGSYP----------PPG-----VFEPSVELEIQIPL----SKLNESVITKAEVESPLL 923
            :|:..|...:|          .||     :|..|:.....:|:    |.|.::.:.:.|.   :|
Frog    84 IQMMKPTSGHPFLKKSTVESSFPGFAVQTIFMRSLNTVALVPIMYSWSPLQQNFMVEDET---VL 145

  Fly   924 SALDIKEDTKKEVGQRVVETLLHKTGG------NLLLK---------RKRKKINRTG--FPTVRR 971
            ..:....|..||..:..:|.|::...|      .|.||         ..|:::.|.|  |.:.|.
Frog   146 CNIPYMGDEVKEEDETFIEELINNYDGKVHGEEELDLKSTMLSSPRLHDRERLFRFGQSFSSGRN 210

  Fly   972 KKRKVSVEQQTTAVIDE------HEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQA 1030
            ...|..     :.::|:      .|......||..:.|..:.......|:.........:|:.:.
Frog   211 STIKTG-----SGLLDDASFLELMEALLQYTDEEEKWLSYSTEGKGEEVKEEGPMTRKRKRIAEE 270

  Fly  1031 GEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEA-APQP-PPKSEPEIR 1093
            |..|.......|.    |...|:..:    .|.||.|...|.:.:|..|| .|.. ||:..|.|.
Frog   271 GSKRVCRSLLPND----LIFSAISAV----FPERGFPEEVKKRYKELTEAYDPNALPPQCTPNID 327

  Fly  1094 PAKKRGRQPKQPV-----------------LEEPPPTPPPQQKKN---KMEPNIRLPDGID---- 1134
            ....:..|.:|.:                 |.....:|...:::|   |:|..   |.||.
Frog   328 GPCAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHASPNVYRRRNREIKIETE---PCGIHCFLW 389

  Fly  1135 ----------PNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAK 1189
                      .|....|..| :|||.............::   .:|...:.....:...:.:||.
Frog   390 LEGAKEYAMMNNPRSKCLGR-RRRKTTALAASGSNSNVME---TKEGDSDRDTGNDCASSSSEAN 450

  Fly  1190 RLDSIPTEH------DPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSN 1248
            .....||:.      ..||          |.:..||..|...:..||.:        :..|.:.|
Frog   451 SRSQTPTKQRQGSLSGELP----------DVSEPSEPVEWSGAEESLFR--------VFHGTYFN 497

  Fly  1249 HYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRN 1313
            ::.........|..|:. .:..|..:.||..|   .|.|..|....:..:.:|.|:.
Frog   498 NFCSIARLMGTKTCKQV-FQFAVTDSLLLKVP---AKELMSTAQKKKRKHRLWAAHC-------- 550

  Fly  1314 VVPSWNYRKIR-------TNVYAESVRPNLAGFDHP------TCNC---KNQGEKSCLDN--CLN 1360
                   |||:       ..||      |....|||      ||.|   :|..||.|..|  |.|
Frog   551 -------RKIQLKKDNSANQVY------NYQPCDHPDHPCDSTCPCIMTQNFCEKFCQCNPDCQN 602

  Fly  1361 RM----VYTECSPSNCP-----------------AGE-------KCRNQKIQRHAVAPGVERFM- 1396
            |.    ..|:|:...||                 |.|       .|:|..|||     |:::.:
Frog   603 RFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDSKVVSCKNCSIQR-----GLKKHLL 662

  Fly  1397 --TAD-KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQR 1458
              .:| .|||...|..:.|..:|.||.||::::.| ..|...:|......:..:|:...|:|..|
Frog   663 LAPSDVAGWGTFIKESVQKNEFISEYCGELISQDE-ADRRGKVYDKYMSSFLFNLNNDFVVDATR 726

  Fly  1459 MGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFS 1508
            .|:..||.|||..|||..:...|||..|:.:||||.|:.||||.:||.:|
Frog   727 KGNKIRFANHSVHPNCYAKVVMVNGDHRIGIFAKRTIQAGEELFFDYRYS 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	25/86 (29%)
		SET	1392..1512	CDD:214614	43/121 (36%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
ezh1	XP_031750333.1	EZH2_WD-Binding	58..84	CDD:402972	169/765 (22%)
		PRC2_HTH_1	216..311	CDD:407952	18/107 (17%)
		SANT	479..520	CDD:238096	7/49 (14%)
		preSET_CXC	606..637	CDD:408079	4/30 (13%)
		SET_EZH1	654..789	CDD:380994	46/129 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000