Protein Alignment ash1 and ehmt2

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_004917185.1
• Gene: ehmt2 / 100484992
• XenbaseID: XB-GENE-487387
• Length: 1150
• Species: Xenopus tropicalis
• Alignment Length: 1435
• Identity: 258/1435 - (17%)
• Similarity: 445/1435 - (31%)
• Gaps: 474/1435 - (33%)

  Fly   247 AKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKMQNE 311
            |.|.|...:.:|....:.|.|::.:..:.|..|||   :::|:.     .|.|:..:|:
 Frog     3 APAGESERMLSAEGADKEGCPERDLVGLSASINSG---DDNAEE-----LSNTREISPA------ 53

  Fly   312 NAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLW 376
            :.:||                       ..|:                   ..:.||.:.:.|:.
 Frog    54 DVIPT-----------------------VEEK-------------------EETEKESVNISPVG 76

  Fly   377 REIDVNKKFRLRSMSVGAASGTGASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASC 441
            |.:..:     .|.|:.....| :|:.|.|:...:.:|    .|.:.|...|          .:.
 Frog    77 RGLSGH-----ASKSLPTPPST-SSSPISSRAKMSLTG----TGKLPHAAQS----------LAM 121

  Fly   442 KSRYSTKSCMSRRSRAKSCGYRS-DCKESG---KSGLRMRRKRRASMLLKSSADDTVEDQDILQL 502
            :....|:....:..||:....|: :...:|   ..|.:...:|.:.|..:.|.|.|.:......:
 Frog   122 RLLNITRDGADKVHRARKTIPRAVNVPGNGVLVSDGEKQSVRRESEMETRDSPDSTQKRSSSSLV 186

  Fly   503 AGLSLGQSSEESNEYISKPSLKSLPTTSASK------------KYG-EINRYVTTGQYFGRGGSL 554
            |.:|..||.|     :...||...|...:|:            :.| |.:.:..:.....:|.|.
 Frog   187 ADISANQSRE-----VEVSSLLLSPEPGSSRDPEGVDAEEWEPEVGAEFSLFYDSFSLEEQGDSD 246

  Fly   555 SATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSL 619
            |....|.......||.:      :||..:|.:......|..:::....:.:||.|.|..:...|:
 Frog   247 SKEEEDEEEEGSGNQSE------RSSSSMKKKTKKKWKMDKAWLKPTRKRKRREREKPVTAVSSV 305

  Fly   620 NIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPA 684
            .:.:...||:.:                                 ..|..||.......:.|...
 Frog   306 GVSNSEYTEVPL---------------------------------GALDLPSEGTLSPNHAGVCN 337

  Fly   685 STLSKPLKR----GLKKRKLSEPLVD--------FAMLSASASGTPNGSGSSNGNTKRRHKKSQS 737
            .|.|...:|    .|...::..|.||        ..|.:.|..|..:|.     |.....:::..
 Frog   338 ETSSMDTERYEELPLCSCRMEAPSVDRVCEQANNMCMATESVDGELSGC-----NVTITKRETMR 397

  Fly   738 NDSSSP-----DDHKLPLKKRH------YLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTAS 791
            ..|..|     :.|:..:.|.|      |..|.|........|
 Frog   398 PSSRVPLMVLCESHRARMVKHHCCPGCGYFCTTGTFLECHPDF---------------------- 440

  Fly   792 TKSQAQFNARSVKSALTPKK-----RHLLEQPTSVSGAGSSASNSPLRIVVDNNSISG--GKLLD 849
                 :.|.|..|:.::|..     .|..|..:.......:.:::|:.|....:...|  |:...
 Frog   441 -----RINHRFHKACVSPLNGIIFCPHCGEDASEAEQITIAKADTPVPIPAPPHHDGGGPGRADT 500

  Fly   850 ISPSSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVIT 914
            ..||:       |..|..:.|.||.:: ...:.|.|         |||.|...:.||...   :.
 Frog   501 TQPSA-------RMRGVGEGKRSALEN-TSNEEPQG---------PSVLLHSGVYLSTAG---LP 545

  Fly   915 KAEVESPLLSALDIKEDTKKEVGQR---VVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRK- 975
            .......|..||..:|......|:.   :.|:||.:       ||.|:|       .:|...|:
 Frog   546 PGHARDALEKALQSQETDSLLQGRNCHSLTESLLQQ-------KRDRRK-------KIRYNSRQL 596

  Fly   976 -VSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLD----------CERVPQ 1029
             :||:|.....:             |..|.:.:.||.:|.|.....||.          |..:.|
 Frog   597 YLSVKQGELQKV-------------LLMLMDNQDSNFLNDQQLKRSPLHAAAQRGSLELCHILVQ 648

  Fly  1030 AGEARETFVARTNQ--KAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEI 1092
            ||.:    :..|::  :.|.|..|....:...:...:   .|....::|:         .....:
 Frog   649 AGAS----INSTDKVLRTPLLEAVVNNHIDIAKYLVQ---CGACVYHKEE---------DGSTCL 697

  Fly  1093 RPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEA---- 1153
            ..|.|.|                                    |....|.:....:.|:.|
 Frog   698 HHAAKSG------------------------------------NLELLCFLLSTGQVNVNAQDNG 726

  Fly  1154 GTQP----KKEKPVQ----------PVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPAS 1204
            |..|    .:.|.:.          .||:::....|.:........||...:  :......|.|.
 Frog   727 GWTPIIWAAEHKHIDVIRTLLTRGADVTLQDNEKNICLHWASFTGSAEIAEV--LLNAQCDLHAV 789

  Fly  1205 ESHNPGPQDYAS------CSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNK 1263
            ..|...|...||      |......:.:.|.:|.
 Frog   790 NFHGDTPLHIASREGFIQCVNLFLSRGADTEIRN------------------------------- 823

  Fly  1264 KPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRT--- 1325
                .|...|         |:..|..|        |:|:|...:    |.:....|.|.:||
 Frog   824 ----NEGDTP---------CDLTLEHT--------DVWYALQLN----RKIRQGINNRAVRTERI 863

  Fly  1326 ------NVYAESVRPNLAGFDHPTC---------NCKNQGEK-----------SCLDNC------ 1358
                  :.|.....|.:.|.|...|         ||:.....           ||:|:|
 Frog   864 ISRDIAHGYERVPIPCVNGVDEELCPDDYKYVSENCETSAMSIDRNITHLQNCSCVDDCSSSNCL 928

  Fly  1359 -------------------LNRM---VYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKG 1401
                               .|::   :..||:.: |...:.|:|:.:| ..:...::.:.||..|
 Frog   929 CGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA-CSCWQTCKNRVVQ-SGIKVRLQLYRTAKMG 991

  Fly  1402 WGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHH-----YCLHLDGGLVIDGQRMGS 1461
            ||||....|.:||:|.|||||::::.|...|....||.|..:     ||        ||.:..|:
 Frog   992 WGVRALQAIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYC--------IDARYYGN 1048

  Fly  1462 DCRFVNHSCEPNCEMQKWSVN----GLSRMVLFAKRAIEEGEELTYDYNFSLFN-PSEGQPCRCN 1521
            ..||:||.||||....:..::    ...|:..|:.|.|..||||.:||....:: .|:...|:|.
 Frog  1049 VSRFINHLCEPNLIPVRVFMSHQDLRFPRIAFFSGRDIRAGEELGFDYGDRFWDIKSKYFTCQCG 1113

  Fly  1522 TPQCR 1526
            :.:|:
 Frog  1114 SERCK 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	38/298 (13%)
		AWS	1340..1388	CDD:197795	15/95 (16%)
		SET_ASH1L	1391..1531	CDD:380951	48/146 (33%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
ehmt2	XP_004917185.1	EHMT_ZBD	348..477	CDD:411018	24/160 (15%)
		ANKYR	574..861	CDD:440430	66/423 (16%)
		ANK repeat	628..657	CDD:293786	6/32 (19%)
		ANK repeat	659..690	CDD:293786	4/33 (12%)
		ANK repeat	692..724	CDD:293786	7/67 (10%)
		ANK repeat	727..757	CDD:293786	5/29 (17%)
		ANK repeat	759..790	CDD:293786	5/32 (16%)
		ANK repeat	792..823	CDD:293786	6/30 (20%)
		SET_EHMT2	890..1128	CDD:380931	61/239 (26%)