Protein Alignment ash1 and Kmt2d

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_063118908.1
• Gene: Kmt2d / 100362634
• RGDID: 2324324
• Length: 5565
• Species: Rattus norvegicus
• Alignment Length: 1942
• Identity: 346/1942 - (17%)
• Similarity: 613/1942 - (31%)
• Gaps: 616/1942 - (31%)

  Fly    15 ETQRAQESGSENEETDSITDQS-------SQSKSIKSATQFSVQRSDTDGLRMRISAIRPTLGVV 72
            :.|:.|:...:.:.:.::..|.       :||: :.|:.|.:.|.....|.|:          :.
  Rat  3806 QQQQQQQQQQQQQHSGALGPQGPHRQVLMTQSR-VLSSPQLAQQGHGLMGHRL----------LT 3859

  Fly    73 ATKKPPKSRKMSTQDTE------SGCSEAKNRAVSK--KVKVKRKKLASSSGISKSDKVSKSKKS 129
            |.::..:.::...|..:      :|.|:.:...:|.  :.|:..:.|.|.....:..:..:.::.
  Rat  3860 AQQQQQQQQQQQQQQQQQQQGSMTGLSQLQQGMMSHGGQPKMSVQALGSLQQQQQQQQQLQQQQQ 3924

  Fly   130 QISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVE 194
            |:.......:..|..:..||..........:|..|...:....:.:....::...|
  Rat  3925 QMQQLQQQQQQQLQQQQQQQMQQLQQQQQQLQQQQQQQQQQQQLHLQQQLHQQQQL--------- 3980

  Fly   195 SDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAV 259
                                  |.|...||...::..:|.|.......:::..:.::.||
  Rat  3981 ----------------------QQQQLQLQQQQQQMSLLNQNRTLLSPQQQQQQQQQVTL----- 4018

  Fly   260 PRKRRGRPKKVVPTVPAPGNSGPAINESADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPIASS 324
               ..|.|.|.:....:||..|||:..:.....|:.|:.....|..|..........|:.|.:.|
  Rat  4019 ---GPGMPVKPLQHFSSPGALGPALLLTGKEQNIAETALPSEVTEGPSAHQGGPPTVGTTPESMS 4080

  Fly   325 -----SKPKI--DMAYLDKRMYATERVLYPP---PRSKRRQNNKKTACSSSNKEEL--------- 370
                 .||.|  |...|..:...|...|.||   |...::.|...|....|:.::|
  Rat  4081 VEPGEVKPSISGDSQLLLVQSQPTSVQLQPPLRLPGQPQQVNLLHTTGGGSHGQQLGSGSSSEAP 4145

  Fly   371 --------------------------QLDPLWREIDVNKKFRLRSMSVGAA-------SGTGAST 402
                                      ...||..|..:......:....|.|       .|.|...
  Rat  4146 SGPHLLAQPSVSLGEQPGPMAQNLLGSQQPLGLERPIQNNTGSQPPKSGPAPQSGQGPPGVGVMP 4210

  Fly   403 TICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRS-------RAKSC 460
            |: .::.|...|.::....:||              .|.:.:...::.:.:|.       |....
  Rat  4211 TV-GQLRAQLQGVLAKTPQLRH--------------LSPQQQQQLQALLMQRQLQQSQAVRQMPP 4260

  Fly   461 GYRSDCKESGKSGL-------RMRRKRRASMLLKSSADDTVEDQDILQL--AGLSLG-------- 508
            |..|..:.|...||       .:....:...|.:..|....:....|.:  ..||.|
  Rat  4261 GQESGTQPSPLQGLLGCQPQPGVFSASQIGPLQELGAGSRPQGPPRLPVPQGALSTGPVLGPVHP 4325

  Fly   509 ----QSSEESN--EYISKPSLKSLPTTSASKK---------YGEINRYVT--TGQYFGRGGSLSA 556
                .|.:|..  ..:..||.:..||...:.|         .|.::....  ...:||:|  |..
  Rat  4326 TPPPSSPQEPKRPSQLPSPSAQLTPTHPGTPKPQGPASELPPGRVSPAAAQLADAFFGKG--LGP 4388

  Fly   557 TNPDNFISKMMNQRKETPA--------------PSKSSCKIKSRRSSAASMCSSYVSGVSRMRR- 606
            .:|.:.:.:.....:.:.|              ||..|.|.:.|....|       .|...::|
  Rat  4389 WDPSDNLPEAQKPEQSSLAAGRLEQVNGQVAHEPSHLSIKQEPREEPCA-------LGAQTVKRE 4446

  Fly   607 ------------RHRRKSFSHNKSLN-IDSKLLTEIEI--------------ITSTFNSRCRIQD 644
                        .|...:.|.:::.: :..|||....:              |....:|:...|:
  Rat  4447 ANGEPAGAPGTSNHLLLAGSRSEAGHLLLQKLLRAKNVQLGAGRGPEGLRAEINGHVDSKLSGQE 4511

  Fly   645 DRLTG-SSGKE------KLLADANKLQAT---LAAPSPAQQLTLNGGGPAS-TLSKPLKRGLKKR 698
            .:|.| ||.||      .|:|...::|.|   ||  |..::|....|..|: .|.|.||:.|.:.
  Rat  4512 QKLQGTSSSKEDAAARKPLMAKPKRVQKTSDRLA--SSRKKLRKEDGVRANEALLKQLKQELSQL 4574

  Fly   699 KLSEPLV--DFAMLSASASGTPNGSGS-SNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHY----- 755
            .|:||.:  :|::.:      |.|||. ..|.::.|.........:.||.:...|.|.:.
  Rat  4575 PLTEPTITANFSLFA------PFGSGCLVGGQSQLRGAFGSGALHTGPDYYSQLLTKNNLSNPPT 4633

  Fly   756 ---LLTPGERPPAEVAFANGKLNAEAWAA----AAAAAKSTASTKSQAQFNARSVKSALTPKKRH 813
               .|.|...|..:....||...:|....    ||:|..|..:.|..|:..:..:.:|| |...|
  Rat  4634 PPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASAQDSERTLKDAAEVKSLDLLAAL-PTPPH 4697

  Fly   814 LLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQR----RGGAAKQKVSAA 874
              .|...|.......|:||..||..:           ||.|:...:..|    ..|..:|...|.
  Rat  4698 --NQTEDVRMESDEDSDSPDSIVPAS-----------SPESILGEEAPRFPQLGSGRWEQDTRAL 4749

  Fly   875 KDLVQLQSPAGSYP------PPGVFEPSV---------------ELEIQIPLS-----KLNESVI 913
            ..::.: .|..|.|      |.||.:..|               |:.:.:.:|     .||..::
  Rat  4750 SPVIPI-IPRTSIPVFPDTKPYGVLDLEVPGKPPATAWEKGKGSEVSVMLTVSAAAAKNLNGVMV 4813

  Fly   914 TKAEV--------------ESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRT 964
            ..||:              :.|..:.|:.|:.          ||  ..:||      |.|.::..
  Rat  4814 AVAELLSMKIPNSYEVLFPDGPARAGLEPKKG----------ET--EGSGG------KEKGLSGR 4860

  Fly   965 G--------------FP--TVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVN 1013
            |              .|  |::.:...:|:.:|.:           |..||......|.:.:|::
  Rat  4861 GPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQES-----------PAPEPSIQHSYTYNVSNLD 4914

  Fly  1014 VQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALER-------LQRPQTPARGRPRGRK 1071
            |:....||      |:......:.:|.:....|...:|.|:.       :..| .|....|...:
  Rat  4915 VRQLSAPP------PEEPSPPPSPLAPSPASPPAEPMVELQAEPPAEPPIPSP-LPLASSPEATR 4972

  Fly  1072 PKNREQAEAAPQPPPKSEPEIRPAKKR-------------------GRQPKQPVLEE-------- 1109
            ||.|      .:||.:||....|..|:                   |||..:..:.|
  Rat  4973 PKPR------ARPPDESEDSRPPRLKKWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTA 5031

  Fly  1110 PPPTPPPQQKKN---------------------------------------------KMEPNIRL 1129
            ..|:..|:..:.                                             .|...:.|
  Rat  5032 LRPSKVPRDNRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVAL 5096

  Fly  1130 PDGI--------------------DPNT-NFSCKIRLK----RRKNLEAGTQPKKEKPVQPVTVE 1169
            ..|:                    .||. :|:|.||.|    :.|.:.......|....|.::..
  Rat  5097 HRGLLTKCSLCQRTGATGSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSF 5161

  Fly  1170 EIPPEIPVSQEEIDAEAEAKRLDSIPTEHD-------------------PLPASESHNPG---PQ 1212
            .:...:.:.::|:      |::.||....:                   |...::.|:..   |.
  Rat  5162 AVFRRVYIERDEV------KQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPV 5220

  Fly  1213 DYAS-----------------CSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQS----LMP 1256
            .|.:                 ||.|..:......:    ||.:..|...:|::...|:    ::.
  Rat  5221 GYEATRIYWSLRTNNRRCCYRCSISENNGRPEFVI----KVIEQGLEDLVFTDASPQAVWNRIIE 5281

  Fly  1257 PPAKVNKKPGL----------EEQVG--------PASLLPPPPYCEKYLRRTEMD--FELPYDI- 1300
            |.|.:.|:..:          ||..|        .|..||....|:.||.|....  .|||..|
  Rat  5282 PVAAMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMIN 5346

  Fly  1301 --WWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHP-TCNCKNQGEKSCLDNCLNRM 1362
              ..|.:..|:.|       :|:::.|::.:.....||.   .| |.|..:..:
  Rat  5347 PTGCARSEPKILT-------HYKRVFTSIISFDPHNNLM---RPHTLNSTSMSK----------- 5390

  Fly  1363 VY--TECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADK-----------GWGVRTKLPIAKGT 1414
            .|  |....:|.|..::..:.|..::      .|..|..|           |.|:.....:.|.|
  Rat  5391 AYQSTFTGETNTPYSKQFVHSKSSQY------RRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHT 5449

  Fly  1415 YILEYVGEVV-------TEKEFKQRMASIY---LNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHS 1469
            .::||:|.::       .||.::::...||   :|:.|          |||....|...|::|||
  Rat  5450 MVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEH----------VIDATLTGGPARYINHS 5504

  Fly  1470 CEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            |.|||..:..:.:...::::.:.|.|.:||||||||.|...:.....||.|....||
  Rat  5505 CAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCR 5561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	63/427 (15%)
		AWS	1340..1388	CDD:197795	8/50 (16%)
		SET_ASH1L	1391..1531	CDD:380951	44/157 (28%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Kmt2d	XP_063118908.1	None