Protein Alignment ash1 and nsd1

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: XP_002936997.3
• Gene: nsd1 / 100145675
• XenbaseID: XB-GENE-989206
• Length: 2440
• Species: Xenopus tropicalis
• Alignment Length: 2300
• Identity: 453/2300 - (19%)
• Similarity: 751/2300 - (32%)
• Gaps: 851/2300 - (37%)

  Fly     1 MSCSQNETAAAKVLETQRAQESGSEN--------EETDSITDQSSQSKSIKSATQFSVQRSDTDG 57
            |:.||.|:..:|.:..:....|..:|        .:.|.:.:||...:..|:.|....::|:
 Frog   532 MAPSQQESCISKQISKEVYNISQEKNVTLSAKKWNKNDELVEQSLGLERTKAQTDNGQEKSE--- 593

  Fly    58 LRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDK 122
                    :|.:|   .|...|.:....:.:.|...:.::...:|    |||:|...|.:|:|.|
 Frog   594 --------KPLMG---HKIEAKQKDFRLKQSVSSVQKERSAGTTK----KRKRLRIHSELSRSSK 643

  Fly   123 --VSKSKKSQISAFSSD----SEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTL-DIGISSSDN 180
              |:.|..|..:..||:    |:|.:...|.......|        .::...|:| ::.:|.|..
 Frog   644 RLVASSLDSSTNVESSNEFSLSKDWVTEDVPDGNGHSV--------DKNKYSPSLTNVSLSDSCE 700

  Fly   181 ELPNLVQAAIKRVESDTEDTTVEG--SFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAE 243
            .|.|.:      :||:....:...  .|.||.    .|:.::.|:.|...:.......:::||.
 Frog   701 NLHNSL------LESNAPSPSQHSIKDFPKAL----TPESKNCLVHDSATQNSQSKNILDSKLG- 754

  Fly   244 EKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPAPGNSGPAIN-------ESADSGVISTTSTTQS 301
            .|.|||   :|.:|       |||:              |:|       :|.||
 Frog   755 HKPAKA---SLGKT-------GRPE--------------AMNLLSNMHEKSCDS----------- 784

  Fly   302 TTPSPKMQNE----NAVPTGSLPIASS-----------SKPKIDMAYLDKRMYATERVLYPPPRS 351
                  |:||    |:|.:|...::|.           |||...:.:
 Frog   785 ------MKNETKLVNSVISGLKELSSRSLSEDGAESTVSKPSTPLLF------------------ 825

  Fly   352 KRRQNNKKTACSSSNKEELQLDPLWREIDV--------NKKFRLRSMSVGAASGTGASTTICSKV 408
                      .|:..:..:.|:|.::..::        :.|.:.|.:..|..:.:..|.. |...
 Frog   826 ----------ASAPGQNRIPLEPDYKFSNLLMMLKDMHDTKTKERKLMTGQNTVSSCSDP-CEDS 879

  Fly   409 LAAKSGYVSDYGSVRHQRSSHNHNS--GYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGK 471
            :......|.|.|.:   ..:|.|::  |...:.:.:|:...                     :|:
 Frog   880 IKGSPDIVPDVGGI---SGNHTHSNEVGMVKEPNNESKLGA---------------------TGQ 920

  Fly   472 SGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKP------------SLK 524
            :.:...||                             .||::::.:..||            |:.
 Frog   921 NKIVCNRK-----------------------------SSSKKNSNFQKKPPMEPKKVSKYKKSMI 956

  Fly   525 SLPTTSASKKYGEI--NRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRR 587
            |....:||.:..|:  |.|.|:.|..|...|.|.|:|.|.........:||...|:.|
 Frog   957 SAQNVNASSECTELTTNSYNTSVQLHGECPSKSITHPYNCSEVGAGYPEETGPGSEQS------- 1014

  Fly   588 SSAASMCSSYVSGVSRMRRRHRRKSFSHN---KSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTG 649
                |.||.:......:..:.|.:...||   .|.|:.:|        .||.:|.|:
 Frog  1015 ----SECSQWNESQKYVAPKKRWQKIKHNGPESSTNLLNK--------ASTKSSLCK-------- 1059

  Fly   650 SSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASA 714
                        |.|..|..|...|...:..|.|                      :.:.::|..
 Frog  1060 ------------KEQDVLEVPKQLQDHEVTFGEP----------------------ELSSIAAQP 1090

  Fly   715 SGTPNGSGSSNGNTKRRHKKSQSND---SSSPDDHK-------LPL----KKRHYLLTPGERPPA 765
            .....||.......||:....:|.|   :|:|..:|       |.|    :|...|:.|.....:
 Frog  1091 EAPKRGSNFGKKYKKRKRFTRRSGDHVKTSTPKINKQKKLGVSLQLEVNKQKNLKLILPAVDFLS 1155

  Fly   766 EVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASN 830
            |:   |.|..:.:..:..|.|.|| .||:.    ....||..:.|:.|.|..|......|.|
 Frog  1156 EI---NSKATSSSQFSKLAEAYST-ETKNP----DNEEKSDSSEKEDHGLASPEQSLSDGFS--- 1209

  Fly   831 SPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDL-VQLQSPAGSYPPPGVFE 894
                   :.:||:       :.|.:..:::.||......:|....|| .||          |:.|
 Frog  1210 -------EPSSIT-------AQSQVNPVRENRRKSKLIPRVCEFDDLDEQL----------GLLE 1250

  Fly   895 PSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTK-KEVGQRVVETLLHKTGGNLLLKRKR 958
                 |...|.:|:.::...|..|         :|:..: :...:|:.|.           :|:|
 Frog  1251 -----EDSKPPAKIAKTTSFKQNV---------LKQSFRYRAASRRLPEN-----------RRRR 1290

  Fly   959 KKINRTG-FPTVRRKKRKVSVEQQTTAVIDEHE----PEFDPDDEPLQ------SLRETR----- 1007
            |:|...| |    :|||.:...|.:....:.||    ...|..:|.|:      ||:..:
 Frog  1291 KRIRLAGKF----KKKRNLISRQSSYPGEEPHENGVASHSDTAEEGLEHELTGASLKRNQGERSG 1351

  Fly  1008 -----SSNNVNVQAAPNPPLDC---------------ERVPQ---------AGEAR---ETFVAR 1040
                 ..|...|...|...|.|               |.:||         :|..:   ..||.:
 Frog  1352 GGAAMKENVCQVCEKPGELLLCEAQCCGAFHLQCLGMEAMPQGKFVCTECSSGTLQGYHTCFVCK 1416

  Fly  1041 TNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQP 1105
            .:.:.          ::|...|..|:        ....|.|.:.||.::      :.||.:....
 Frog  1417 ESDQG----------VKRCMLPLCGK--------YYHEECALKYPPATQ------QNRGFRCSLH 1457

  Fly  1106 VLEEPPPTPP--PQQKKNKMEPNIR-----------LPDG---------IDPNTNF--------- 1139
            :......|.|  |...|.::...:|           ||.|         |.|| :|
 Frog  1458 ICSTCYATNPSNPSASKGRLMRCVRCPVAYHANDFCLPAGAVTLASNSIICPN-HFTPRRGCKNH 1521

  Fly  1140 ---------------------SCKIRLKRR-------------KNLEAGTQPKKEK--------- 1161
                                 ||.....|.             .:.:||.:|..::
 Frog  1522 EHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWFCNDCKAGKKPHYKEVVWVKVGRY 1586

  Fly  1162 ---PVQPVTVEEIPPEIPVSQEEID-----------------------AEAEAKRLDSIPTEHDP 1200
               |.:....:.|||.|...:.:|.                       .|.:|...|.:....|.
 Frog  1587 RWWPAEVCHPKTIPPNIQKMKHDIGEFPVVFFGSKDYLWTHQARVFPYMEGDALNKDKMSKGMDA 1651

  Fly  1201 LPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKP 1265
            :     :..|..:.|   |..|:..:...:|:|.:.||.                      :||
 Frog  1652 V-----YKKGLMEAA---ERFEELKAQKEMRQLQEDKKN----------------------DKK- 1685

  Fly  1266 GLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAE 1330
                         |||                                      |:.|:.|....
 Frog  1686 -------------PPP--------------------------------------YKHIKVNRPVG 1699

  Fly  1331 SVRPNLAGFDH-PTCNCKNQGEKSCLDN--CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGV 1392
            .|:...|.... |.||||...|..|..:  |:|||:..||.||.|||||:|:||...:... |.|
 Frog  1700 KVQILTADLSEIPRCNCKATDENPCGQDSECINRMLLYECHPSVCPAGERCQNQAFSKRQY-PEV 1763

  Fly  1393 ERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDG 1456
            |.|.|..:|||:|.:..|.||.::.|||||::.|:|.:.|:......| |:.|.|.||...|||.
 Frog  1764 EIFRTLSRGWGLRCRTDIKKGEFVNEYVGEMIDEEECRARIRYAQEQDITNFYMLTLDKDRVIDA 1828

  Fly  1457 QRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCN 1521
            ...|:..||:||.|:||||.|||:|||.:|:.|||...|:.|.|||::||.......: ..|:|.
 Frog  1829 GPKGNFARFMNHCCQPNCETQKWTVNGDTRVGLFALCDIKAGVELTFNYNLECLGNGK-TVCKCG 1892

  Fly  1522 TPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRN-GRQRKQKAKK-------------------- 1565
            .|.|.|.:|             .:|..:.:|..: |::|||..|:
 Frog  1893 APNCSGFLG-------------VRPKNQPVSSEDKGKKRKQYVKRKKSEVVKEHEDECFSCGDGG 1944

  Fly  1566 --------------HAQ------RQAGK--------DI--SSAVAVAKLQP-------------L 1587
                          ||:      |.|||        ||  ..|.::.::.|             :
 Frog  1945 QLVSCKKPGCPKVYHAECLKLTRRPAGKWECPWHQCDICHKEAASLCEMCPSSFCKQHREGMLFI 2009

  Fly  1588 SEKEKKL-----------------VRQFNTFLVRNFEKIRRCKAKRASDAA--ATASS------- 1626
            |:.:.:|                 :|::::...:|.........|:..|:|  .||||
 Frog  2010 SKLDGRLSCTEHDPCGPHPLEPGEIREYDSSNEQNDSAGPSLPKKKTLDSAKGKTASSNSHKKNV 2074

  Fly  1627 ----------PALGTTNGDIPGRRPSTPSSPSLAAQISALCSPRNIKTRG----LTQAVHDP--- 1674
                      .|..|::|::......:....||:|....|.|.....|.|    |..|:...
 Frog  2075 SVTEVLHTPTTAGSTSSGNVSKENVGSVEQKSLSAGKILLASAGQKCTTGSKLLLASAIQKSLPA 2139

  Fly  1675 ---ELEKMAKMA-----VVLRDI----CSAMETL---------KMSDLLTTVSSKKKKPI----- 1713
               .|..:.|.:     |:|..|    .||.:.|         .:..::.:.:.|...|.
 Frog  2140 GKVVLTSLGKKSLPAGKVLLASIGKKQLSAGKVLVTSLGKNSPSVGRMIISTAGKHSLPAGKVLL 2204

  Fly  1714 ----KTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHG------DD 1768
                |.|.:||:..|:||::      .:..|:.  |..::.|....|..::...:|.      :.
 Frog  2205 ASAGKYTTAGKVLLTSATNQ------HSTAEKN--KADKQNDVKETQNSLDPDTKHRITKKPLNK 2261

  Fly  1769 EGKEKALQSLKDSYEQ------QKIASYVQLVEILGDSESLQSFKPKE----------------- 1810
            ..|:|...:|:....|      ||..|..|:......|.:.:..|||:
 Frog  2262 PSKDKLNTTLEQPLTQNHTTGIQKPVSPCQVERPSNPSLTGRPEKPKDKHQPDSEVHPKILLKRS 2326

  Fly  1811 -------VLSSEEEPGKIAVKK--------------------SPGAKERDSPIVP----LKVTPP 1844
                   .||:.:|..:|:.||                    ||..||:  |..|    |.....
 Frog  2327 TMPTSRRSLSAHKERFQISTKKEGSLESSQVENHATPRKDSCSPTVKEK--PSAPSERSLSTVES 2389

  Fly  1845 PLLPIEASPDEDVIRCI-CGLYKDE 1868
            |.:|  |:|:....|.| |.|...|
 Frog  2390 PSIP--AAPENSSGRAISCTLASSE 2412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	57/389 (15%)
		AWS	1340..1388	CDD:197795	23/50 (46%)
		SET_ASH1L	1391..1531	CDD:380951	60/140 (43%)
		Bromo_ASH1	1680..1787	CDD:99955	26/145 (18%)
		PHD_ASH1L	1858..1900	CDD:277023	4/11 (36%)
		BAH_polybromo	1929..2073	CDD:240068
nsd1	XP_002936997.3	PWWP_NSD1_rpt1	314..428	CDD:438989
		PHD1_NSD1_2	1360..1402	CDD:277118	7/41 (17%)
		PHD2_NSD1	1411..1457	CDD:277120	11/69 (16%)
		PHD3_NSD1	1458..1511	CDD:277123	11/53 (21%)
		PHD4_NSD1	1528..1567	CDD:277126	3/38 (8%)
		PWWP_NSD1_rpt2	1574..1669	CDD:438992	14/102 (14%)
		AWS	1720..1758	CDD:465559	18/37 (49%)
		SET_NSD1	1760..1901	CDD:380987	61/142 (43%)
		PHD5_NSD1	1936..1978	CDD:277129	6/41 (15%)
		C5HCH	1977..2026	CDD:465605	6/48 (13%)
		PTZ00449	<2209..>2434	CDD:185628	45/215 (21%)