DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and nsd2

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_002936809.1 Gene:nsd2 / 100125213 XenbaseID:XB-GENE-988824 Length:1298 Species:Xenopus tropicalis


Alignment Length:1459 Identity:314/1459 - (21%)
Similarity:497/1459 - (34%) Gaps:437/1459 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 VAKAKEETLVQTAVPRKRRGRPKKVVPTVPAP-----------GNSGPAINESA---DSGVISTT 296
            :.:|:....:|..|.:|..|...  :|.:|..           |.||  ..|:.   ::..:...
 Frog    28 LGRAQISASLQEGVIQKLNGHDS--LPFIPTEKLKDLTSRVFNGESG--AQEAKVRFEAQEVQGI 88

  Fly   297 STTQSTTPSPKMQNENAVPTGSLPIAS---SSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNK 358
            .|..||||:     :|..|...|.|..   :.||..:.:....|   .|....|..:..:|...:
 Frog    89 ETPPSTTPT-----KNGSPEIKLKITKTYMNGKPLFESSICGDR---GEEEPQPEQKKSKRGRKR 145

  Fly   359 KTACSSSNK----------EELQLDPL----WREIDVNKKFRLRSMSVGAASGTGASTTICSKVL 409
            |...|.:|:          |..::.|:    :.|....:.|.|: .|||        ..:.||| 
 Frog   146 KIITSEANEKSSSEMPSHSESSKMKPVSESEFLEHKNKEDFSLK-YSVG--------DVVWSKV- 200

  Fly   410 AAKSGY-------VSD-----YGSVRHQRSS-HNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCG 461
               |||       .||     :..|:.|:.: ..::..:..:|..::..|.||.:..:...:   
 Frog   201 ---SGYPWWPCMVTSDPVLYSHTKVKGQKKNVRQYHVQFFGNAPERAWISEKSMVPFKGENE--- 259

  Fly   462 YRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDI-LQLAGLSLGQSSEESNE-----YI-S 519
            |...|:||.|   :...|...:.|||..........|| ::.|...:..:.||..|     || .
 Frog   260 YDHLCQESAK---QAPTKAEKTKLLKPITGKIRAQWDIGIEQAKEGILMTPEERKEKFTFIYIKD 321

  Fly   520 KPSLK-------SLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRK--ETPA 575
            :|.|.       .:|..|:.|                     |..:|....|....:|:  .|||
 Frog   322 RPQLNPRVASEVGVPVESSEK---------------------STESPQKEGSSSYKRRRVSRTPA 365

  Fly   576 PSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHR--------RKSFSHNKSLNIDSKLLTEIEII 632
            .||.........::.....||...|::....:.|        ||..:.|:.|....|...|:   
 Frog   366 ASKEVDPADKTTTAKGPENSSDPKGMTSPASKKRSGAYTPRSRKGDAVNQFLVFCQKHKDEV--- 427

  Fly   633 TSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKK 697
               .|......|:.:     :|.|.:..|.|       |..|:...|                  
 Frog   428 ---INEHPDASDEEI-----EELLESQWNML-------SNKQKARYN------------------ 459

  Fly   698 RKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKK-RHYLLTPGE 761
                   ..||:|::..|  ...|||.:|: ||.|.|:..|.:...:..:.|.|: |.:.....|
 Frog   460 -------TKFAILTSPKS--EEDSGSLHGH-KRNHLKTTHNQTEDSEIQESPRKRLRMHNRKQRE 514

  Fly   762 --RPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTP-KKRHLLEQPTSVSG 823
              :||.              |.|:|..|:     |.|.|   |:..|..| |||:......||: 
 Frog   515 TCKPPK--------------ARASAPVKN-----SPAMF---SLSDACKPLKKRNRSSTLGSVA- 556

  Fly   824 AGSSASNSPLRIVV--------DNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQL 880
            ...|.|:||..:..        |..|.|..:..|.|.:.:..|.::...||.|:           
 Frog   557 LPVSKSSSPASLTENEVSDSQGDERSESPSESADESQAEISMLHRKSERGAMKK----------- 610

  Fly   881 QSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPL-LSALDIKEDTKKEVGQRVVETL 944
                             ||..|: ..|:.:.::.:....|.. ||.:.:   :.:..|:.:.:..
 Frog   611 -----------------ELVCQV-CEKVGDLMLCEGVCCSAFHLSCIGL---STRPAGKYLCKEC 654

  Fly   945 LHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSS 1009
            ........|.|...:.:.|...|...:...:..:.:...||.:......     ||........|
 Frog   655 TSGARSCFLCKESNRDVKRCIVPHCGKFYHESCLRKYPLAVFESRGFRC-----PLHRCATCYFS 714

  Fly  1010 NNVNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKP-- 1072
            |..|.:|:....:.|.|.|.|....|:.:..........|::.....      |..:.:....  
 Frog   715 NPSNPRASKGKMVRCVRCPLAYHGAESCIVAGCTALTSTSIICSSHF------AANKAKSHHAHI 773

  Fly  1073 --------KNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRL 1129
                    .|..........|....|:..                                ||.:
 Frog   774 NVSWCFVCSNGGSLLCCESCPAAFHPDCL--------------------------------NIEM 806

  Fly  1130 PDGIDPNTNF--SCKIRLKRRKN----LEAGTQPKKEKPVQPVTVEEIPP----------EIPV- 1177
            |||    :.|  .|::..|.|.|    ::.|..  :..|.:....:.:||          |.|| 
 Frog   807 PDG----SWFCNDCRLGKKPRFNDIIWVKLGNY--RWWPAEVCHPKNVPPNIQKMKHAIGEFPVF 865

  Fly  1178 ----------SQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRK 1232
                      .|..:....|..|             ...|:.|                    :.
 Frog   866 FFGSKDYYWTHQARVFPYMEGDR-------------GSKHHGG--------------------KS 897

  Fly  1233 LSKVKKTYLVAGLFSNHYKQSLMPPPAKV---NKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDF 1294
            :.||.|..|...  ...:.:.:....|||   |:|             .||||  |:::..:   
 Frog   898 IGKVFKNALQEA--ETRFCEIMRQREAKVTQENEK-------------KPPPY--KHIKVNK--- 942

  Fly  1295 ELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCNCKNQGEKSC-LDN- 1357
              ||.                        :..||...:.      :.|.||||...||.| .|: 
 Frog   943 --PYG------------------------KVQVYTADIS------EIPKCNCKPSSEKPCGFDSE 975

  Fly  1358 CLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGE 1422
            |||||:..||.|..||||::|:||...:... |..:...|..||||:.....|.||.::.||:||
 Frog   976 CLNRMLMYECHPQVCPAGDRCQNQCFNKRQY-PETKIIKTEGKGWGLIATRDIKKGEFVNEYIGE 1039

  Fly  1423 VVTEKEFKQRMASIYLND-THHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSR 1486
            ::.|:|...|:.....|| ||.|.|.:|...:||....|:..||:||||:||||.|||||||.:|
 Frog  1040 LIDEEECMYRIRHAQENDITHFYMLTIDKDRIIDAGPKGNFSRFMNHSCQPNCETQKWSVNGDTR 1104

  Fly  1487 MVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGK---------SQRVKPLPAV 1542
            :.|||.|.|..|||||::||..... :|...|||..|.|.|.:|.:         .::||     
 Frog  1105 VGLFAVRDIPAGEELTFNYNLDCLG-NEKTICRCGAPNCSGFLGDRPKNNTASSHEEKVK----- 1163

  Fly  1543 EAKPSGEGLSGRNGRQRKQKAKKHAQRQA 1571
              ||        ..:|:|::.|...::|:
 Frog  1164 --KP--------KKKQKKRRTKTDGKKQS 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 24/49 (49%)
SET 1392..1512 CDD:214614 55/120 (46%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
nsd2XP_002936809.1 MSH6_like 188..307 CDD:99898 30/137 (22%)
HMG-box 414..463 CDD:238037 13/91 (14%)
TNG2 <484..654 CDD:227367 45/224 (20%)
PHD1_NSD1_2 613..655 CDD:277118 6/45 (13%)
PHD2_NSD2 660..706 CDD:277121 7/50 (14%)
PHD3_NSD2 707..760 CDD:277124 10/52 (19%)
PHD4_NSD2 777..817 CDD:277127 9/75 (12%)
WHSC1_related 822..916 CDD:99899 18/130 (14%)
AWS 967..1004 CDD:375420 19/36 (53%)
SET_NSD2 1006..1147 CDD:380988 63/142 (44%)
PHD5_NSD2 1185..1227 CDD:277130
C5HCH 1226..1273 CDD:375464
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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