Protein Alignment ash1 and setdb2

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001096194.1
• Gene: setdb2 / 100124743
• XenbaseID: XB-GENE-1219030
• Length: 697
• Species: Xenopus tropicalis
• Alignment Length: 848
• Identity: 145/848 - (17%)
• Similarity: 228/848 - (26%)
• Gaps: 412/848 - (48%)

  Fly   919 ESPLLSAL--DIKEDTKKEVGQR---------VVETLLHKTGGNLLLKRKRKKINRTGFPTVRRK 972
            ||..||.|  |:..:..||..:.         :.|.||:|.   .:|.:|.|..:.|....||
 Frog    18 ESNTLSVLSKDVSLEDAKEYWKDCQADGKVDWIFEKLLNKL---KILWQKIKDGSATNLEYVR-- 77

  Fly   973 KRKVSVEQQTTAVIDEHEPE-FDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARET 1036
                       |||..:|.| .:.|.|.|.:  :.:..|.|....      ||     |.|.:|.
 Frog    78 -----------AVILVNEAEQLEEDTETLHT--DIQKENKVQENT------DC-----APERKED 118

  Fly  1037 FVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPP-------------PKS 1088
            ..|..|...              :|...|      .:...:..:...||             |..
 Frog   119 SCADLNSDC--------------ETDVSG------SECEHEDHSTVSPPATGAVCFGKHLCGPSC 163

  Fly  1089 EPEIRPAKKRGRQP-KQPV-------------LEEPP----PTPPPQQKKNKMEPNIRLPD---- 1131
            ..:|.|:..:...| ..||             .|.||    ..|..:..::..|.:..|.:
 Frog   164 LSDINPSLLKKENPLNLPVSCDFQRWRVKTNGSEYPPHILYKAPCGRSLRDSDEVHSYLTETGCH 228

  Fly  1132 --GIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVS-QEEIDAEAEAKRLDS 1193
              |:| |.:||.:::|:...::       |::.||...:......:||| ..|||        |:
 Frog   229 FLGVD-NFSFSTQVQLESHLSI-------KQEIVQDCDISNDVESVPVSLSNEID--------DT 277

  Fly  1194 IPTEHDPLPASESHNPGPQDYA------------SCSESSEDKASTTSLRKLSKVKKTYLVAGLF 1246
            .||..  :....|..||   |:            ||::...|.::.:.|:         |.|..|
 Frog   278 RPTNF--IYRKTSWPPG---YSINNFTDIFVKCCSCTDGCLDISTCSCLQ---------LTAQAF 328

  Fly  1247 SNHYKQSLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPT 1311
            ......||               .:||.                            .|.:.:|
 Frog   329 EKFTDSSL---------------GIGPL----------------------------GYKHKRL-- 348

  Fly  1312 RNVVPSWNYRKIRTNVYAESVRPNLAGFDHPTCN--CKNQGEKSCLDNCLNRMVYTECSPSNCPA 1374
            :..||:..|.                      ||  ||      | |..|
 Frog   349 QEPVPTGLYE----------------------CNLSCK------C-DRTL--------------- 369

  Fly  1375 GEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTE------------- 1426
               |:|:.:| |.:...::.|.|..||||||....:..||::..|.|.::..
 Frog   370 ---CQNRVVQ-HGLQLRLQVFKTDTKGWGVRCLDDVDNGTFVCIYAGRILIRTADSSVKTTLEDS 430

  Fly  1427 -------KEFKQRMASIYL---------NDTHHYCLHL-------------------------DG 1450
                   ||.....:::.|         :|:....:||                         .|
 Frog   431 VACGNEAKEDNGSTSTLMLSKRKRKPSHSDSEVTVMHLTPYSMRSLGLSVHRQSNTLSLTHLRSG 495

  Fly  1451 GLVI------------------------------------------------------------- 1454
            |..|
 Frog   496 GREISLEPFRRPKTKTSMLQKRRRQLIEEGACTVHNSSEEEGPTPPQSPKQKFNAGRKIHRNENS 560

  Fly  1455 --------------------------------------------------------DGQRMGSDC 1463
                                                                    |..:.|:..
 Frog   561 DETASGYVSEESSSSVISGGHPSEKPTCRTKSKLNKMTPHLSTSPEQTCEEDLHFLDASKEGNVG 625

  Fly  1464 RFVNHSCEPNCEMQKWSVNGLSR----MVLFAKRAIEEGEELTYDYNFSLFN-PSEGQPCRCNTP 1523
            ||:||||.||..:|...|:...:    :..|....::.|.|||:|||:.:.. |.:...|.|...
 Frog   626 RFLNHSCCPNLFVQHVFVDTHQKSFPWVAFFTNSVVKAGTELTWDYNYVIGTAPDQEIQCLCGQQ 690

  Fly  1524 QCR 1526
            .|:
 Frog   691 TCK 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	56/312 (18%)
		AWS	1340..1388	CDD:197795	11/49 (22%)
		SET_ASH1L	1391..1531	CDD:380951	45/312 (14%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
setdb2	NP_001096194.1	HMT_MBD	177..237	CDD:238689	12/60 (20%)
		SET	235..696	CDD:394802	91/581 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	438..461		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..605		0/75 (0%)