DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14100 and mrm3b

DIOPT Version :9

Sequence 1:	NP_649130.2	Gene:	CG14100 / 40132	FlyBaseID:	FBgn0036889	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001157404.1	Gene:	mrm3b / 792923	ZFINID:	ZDB-GENE-030131-158	Length:	449	Species:	Danio rerio

Alignment Length:	472	Identity:	122/472 - (25%)
Similarity:	199/472 - (42%)	Gaps:	115/472 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CNIFKRSLQANIRNVNNLNVLRLSSSSGPRGEIQDALDIEANLFGNSDLRHEPMN---TREALRK 64
            |.:|:.:|......||....:|...:......:.:..:|...:...:..|....|   ||
Zfish    12 CALFQSALTLGRNEVNIKRYVRRRRAVSGVISVNEPTEISEGVISQTSERSSQHNNDITR----- 71

  Fly    65 NRFAGRKPKVPFASVASRNLSAPSNPAPRVAPTPAPVIKDNELN------------------LEF 111
                            :.:.|:..||   |:|..:..::.:.:|                  |.:
Zfish    72 ----------------NTDKSSIENP---VSPNNSQPVQFSHINRQKVINLTSRTRFGEVDGLLY 117

  Fly   112 VRLTLQDPLTSTLLTTVRSRKRRDKNRQIIVEGRRLIQEALQCGLKMEVLLFSQKDQLALVKEEV 176
            .:|...|...:.|.....|:|.|:  .|:::||:.|:..||..|.:.:.|.||..|.|    .|:
Zfish   118 EKLHPGDKSLAKLARIAGSKKLRE--HQVVLEGKHLVCSALDAGAEAQTLYFSSVDAL----REL 176

  Fly   177 GVAQVETGTKIYKVPQHDLKTWSSLVTPPGLMAIFDRPSDKGLEKNLAEQQRLGSQPFPITVVCD 241
            .:.::.. |.:.||...|.:.||.|.|...::|||.||....|   ...:::.| :..|:|::||
Zfish   177 PLDKLRQ-TNVVKVKMEDAQVWSELDTSQEIIAIFKRPEASRL---TFSEEKYG-RAVPLTLICD 236

  Fly   242 NIREPNNLGSIIRTCAALPCSQVVVTHGCCDPWESKALRGGCGGQFRVPIRDDVTWDELALTIPP 306
            .:|:|.||||::|:.||..|..|::|.||.|.||.|.||...|..||:||..::||.:::..:|.
Zfish   237 TVRDPGNLGSVLRSAAAAGCHSVLLTKGCVDIWELKVLRAAMGAHFRLPIIPNLTWTDISNHLPK 301

  Fly   307 EAADDCHVFIAE---TNQRKRENNQT-------IDYADIKG------------------------ 337
            .:.    |.:|:   |...|..:|.|       .||..:||
Zfish   302 TST----VHVADNHSTTMAKHNDNTTPQKHRRPSDYGWVKGHQYQSKAHDDDDDDDDANDLCSLE 362

  Fly   338 -------------------LGAHNLLIIGGESHGVSEEAYRFLNLVGGKGKCIYIPLAAGIDSLN 383
                               :..|..||||||:||:|.||.:......|:.  :.||:..|:||||
Zfish   363 DYCDKNSKSLETQLYYTDWVAGHTSLIIGGETHGLSREALQLAERTSGRR--LLIPMVDGVDSLN 425

  Fly   384 VASALTLLLFELRRKLI 400
            .|.|..:||||.|::|:
Zfish   426 SAIAAGVLLFEGRKQLL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14100	NP_649130.2	SpoU	131..399	CDD:223640	99/320 (31%)
		SpoU_sub_bind	141..214	CDD:285300	23/72 (32%)
		SpoU_methylase	235..393	CDD:278985	65/210 (31%)
mrm3b	NP_001157404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..90		9/61 (15%)
		SpoU	131..444	CDD:223640	101/329 (31%)
		SpoU_sub_bind	146..211	CDD:214943	22/69 (32%)
		SpoU_methylase	230..435	CDD:278985	65/210 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..334		5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581269
Domainoid	1	1.000	102	1.000	Domainoid score	I6794
eggNOG	1	0.900	-	-		E1_COG0566
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4125
OMA	1	1.010	-	-		QHG50134
OrthoDB	1	1.010	-	-		D1183644at2759
OrthoFinder	1	1.000	-	-		FOG0006042
OrthoInspector	1	1.000	-	-		otm24765
orthoMCL	1	0.900	-	-		OOG6_102998
Panther	1	1.100	-	-	O	PTHR43191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4335
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770