DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14100 and MRM3

DIOPT Version :9

Sequence 1:	NP_649130.2	Gene:	CG14100 / 40132	FlyBaseID:	FBgn0036889	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_060616.1	Gene:	MRM3 / 55178	HGNCID:	18485	Length:	420	Species:	Homo sapiens

Alignment Length:	416	Identity:	129/416 - (31%)
Similarity:	213/416 - (51%)	Gaps:	58/416 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PRGEIQDALDIEANLFGNSDLRHEPMN----TREALRKNRFAGRKP-KVPF-ASVASRNLSAPSN 89
            |..::..|.|::|..:..: ||..|:.    :.|.:.:.|..|::| |.|. ||...:....|..
Human    14 PLLQVVQAWDLDARRWVRA-LRRSPVKVVFPSGEVVEQKRAPGKQPRKAPSEASAQEQREKQPLE 77

  Fly    90 PAPRVAPTPAPVIKDNELNLEFVRLTLQDPLTSTLLTTVRSRKRRDKNRQIIVEGRRLIQEALQC 154
            .:...||:..     .|..|.:.:....|...|:::|.|:||..|:|..:|::||||||.:||:.
Human    78 ESASRAPSTW-----EESGLRYDKAYPGDRRLSSVMTIVKSRPFREKQGKILLEGRRLISDALKA 137

  Fly   155 GLKMEVLLFSQKDQLALVKEEVGVAQVETGTKIYKVPQHDLKTWSSLVTPPGLMAIFDRPSDKGL 219
            |...::..||:.:.|    :|:.|.::: |..:.||...|:|.||.||||.|:|.||.:|....:
Human   138 GAVPKMFFFSRLEYL----KELPVDKLK-GVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDHVKM 197

  Fly   220 EKNLAEQQRLGSQPFPITVVCDNIREPNNLGSIIRTCAALPCSQVVVTHGCCDPWESKALRGGCG 284
            .....:.|    ...|:.::|||:|:|.|||:|:|:.|...||:|::|.||.|.||.|.||.|.|
Human   198 TYPKTQLQ----HSLPLLLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMG 258

  Fly   285 GQFRVPIRDDVTWDELALTIPPE----AADDCHVFI-AETNQRKRENNQTIDYADIK-------- 336
            ..||:||.:::.|:.:...:||:    .||:|.::. ||.:.:..::....|...:|
Human   259 AHFRMPIINNLEWETVPNYLPPDTRVYVADNCGLYAQAEMSNKASDHGWVCDQRVMKFHKYEEEE 323

  Fly   337 --GLGAHN--------------------LLIIGGESHGVSEEAYRFLNLVGGKGKCIYIPLAAGI 379
              ..||..                    .::||||::|||.|:.:.....|||.  :.||:..|:
Human   324 DVETGASQDWLPHVEVQSYDSDWTEAPAAVVIGGETYGVSLESLQLAESTGGKR--LLIPVVPGV 386

  Fly   380 DSLNVASALTLLLFELRRKLIHQASE 405
            ||||.|.|.::||||.:|:|..:|.:
Human   387 DSLNSAMAASILLFEGKRQLRGRAED 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14100	NP_649130.2	SpoU	131..399	CDD:223640	102/302 (34%)
		SpoU_sub_bind	141..214	CDD:285300	29/72 (40%)
		SpoU_methylase	235..393	CDD:278985	63/192 (33%)
MRM3	NP_060616.1	SpoU_sub_bind	125..191	CDD:214943	29/70 (41%)
MRM3	NP_060616.1	SpoU-like_RNMTL1	210..402	CDD:349979	64/193 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6526
eggNOG	1	0.900	-	-		E1_COG0566
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10033
Inparanoid	1	1.050	180	1.000	Inparanoid score	I4010
Isobase	1	0.950	-	0	Normalized mean entropy	S7460
OMA	1	1.010	-	-		QHG50134
OrthoDB	1	1.010	-	-		D1183644at2759
OrthoFinder	1	1.000	-	-		FOG0006042
OrthoInspector	1	1.000	-	-		oto89033
orthoMCL	1	0.900	-	-		OOG6_102998
Panther	1	1.100	-	-	LDO	PTHR43191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4335
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790