DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9330 and NEW1

DIOPT Version :9

Sequence 1:	NP_649129.1	Gene:	CG9330 / 40131	FlyBaseID:	FBgn0036888	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_015098.1	Gene:	NEW1 / 855875	SGDID:	S000006147	Length:	1196	Species:	Saccharomyces cerevisiae

Alignment Length:	789	Identity:	222/789 - (28%)
Similarity:	317/789 - (40%)	Gaps:	239/789 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LQSVDCDRSEESVRTLCEQFLNIMK-NNEVNVERKVLNAPVNIEE------------------MA 93
            :|.|....|...||.|.|:.||::| ::|.:.|.| .:..:.:||                  ..
Yeast   435 IQKVVDTASLPEVRELAEKALNVLKEDDEADKENK-FSGRLTLEEGRDFLLDHLKDIKADDSCFV 498

  Fly    94 K---NMERLDKDMQSIWVANKDGANKVDSKKLGKAEAKLQQKQEKRQEVNKHGMIPVAVKLQTAT 155
            |   |.|.:.|.|..|...:   :|..|.|:|......:....:.::|..|...|      ....
Yeast   499 KPYMNDETVIKYMSKILTVD---SNVNDWKRLEDFLTAVFGGSDSQREFVKQDFI------HNLR 554

  Fly   156 ASQVTNKKNTKLDQKGLNRSMDIKIENFDLAFGEKVLLQNANLLLSYGRRYGLVGRNGLGKTTLL 220
            |.....|:....|:     .::|...:|.||:|.::||...||.|..|.||||.||||.||:||:
Yeast   555 ALFYQEKERADEDE-----GIEIVNTDFSLAYGSRMLLNKTNLRLLKGHRYGLCGRNGAGKSTLM 614

  Fly   221 RMIAERQLQIPSHISVLHVEQEVVGDDTPAVESVLECDTERTRLLTREKEILAALNNGVQDATLS 285
            |.||..||                 |..|..:::..|..|. :|...|.::     :.|....|.
Yeast   615 RAIANGQL-----------------DGFPDKDTLRTCFVEH-KLQGEEGDL-----DLVSFIALD 656

  Fly   286 NELSETYASLQNIEADKAVARASVILKGLGFDADMQLRPTKSFSGGWRMRLALARALFSKPDLLL 350
            .||..|  |.:.|.|         .|:.:|||.:.:.:...|.||||:|:|.||||:..|.|:||
Yeast   657 EELQST--SREEIAA---------ALESVGFDEERRAQTVGSLSGGWKMKLELARAMLQKADILL 710

  Fly   351 LDEPTNMLDIKAIIWLENY-LQTWATTILVVSHDRNFLDTVPTDIIHLHSQELEAYKGNYEQFEK 414
            ||||||.||:..:.|||.| |:....|.|:||||..|||||.|||||..:::|..||||...|.:
Yeast   711 LDEPTNHLDVSNVKWLEEYLLEHTDITSLIVSHDSGFLDTVCTDIIHYENKKLAYYKGNLAAFVE 775

  Fly   415 TKTEKLKSQRREYEAQMAHRAHVQDFIDRFRYNANRASSVQSKIKMLEKLPELKPVEKETVVTLK 479
            .|.| .||                       |.....|:.|                      ::
Yeast   776 QKPE-AKS-----------------------YYTLTDSNAQ----------------------MR 794

  Fly   480 FPEVEPLNPP------------VLAISEVTFRYNPEDPLPIFKGVNLSATSDSRICIVGENGAGK 532
            ||      ||            |..:::|||.| |....|....|:.|.:..||:..:|.|||||
Yeast   795 FP------PPGILTGVKSNTRAVAKMTDVTFSY-PGAQKPSLSHVSCSLSLSSRVACLGPNGAGK 852

  Fly   533 STLLKIIVGQLSTIHGNIVLHRGLRIGYFAQHHVDHLNMN------------------------- 572
            |||:|::.|:|....|.:..|..|||||.|||.:.|:|.:
Yeast   853 STLIKLLTGELVPNEGKVEKHPNLRIGYIAQHALQHVNEHKEKTANQYLQWRYQFGDDREVLLKE 917

  Fly   573 ---------------------------VTCVG----------------------------VLAE- 581
                                       ...||                            ||.|
Yeast   918 SRKISEDEKEMMTKEIDIDDGRGKRAIEAIVGRQKLKKSFQYEVKWKYWKPKYNSWVPKDVLVEH 982

  Fly   582 ----LFPGRPDEEYRRQ-LG--------------SFGISGPLALQS-IASLSGGQKSRVALAKMC 626
                |.....|.|..|: ||              ..|:...:|..: :.||||||..:|.:|...
Yeast   983 GFEKLVQKFDDHEASREGLGYRELIPSVITKHFEDVGLDSEIANHTPLGSLSGGQLVKVVIAGAM 1047

  Fly   627 MAEPNFLVLDEPTNHLDIETIDALGRAINAFKGGVILVSHDERLIKVVCKELWVCGN-RTVRAIE 690
            ...|:.||||||||:||.:::.||..||..:.|||:::||:...:..:|.|.|:..| :.|:...
Yeast  1048 WNNPHLLVLDEPTNYLDRDSLGALAVAIRDWSGGVVMISHNNEFVGALCPEQWIVENGKMVQKGS 1112

  Fly   691 GGLDEYKRE 699
            ..:|:.|.|
Yeast  1113 AQVDQSKFE 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9330	NP_649129.1	PLN03073	1..698	CDD:215558	220/786 (28%)
		ABCF_EF-3	178..401	CDD:213188	90/223 (40%)
		ABC_tran_Xtn	395..480	CDD:289608	15/84 (18%)
		ABCF_EF-3	491..685	CDD:213188	79/295 (27%)
NEW1	NP_015098.1	HEAT repeat	183..214	CDD:293787
		HEAT repeat	224..253	CDD:293787
		HEAT repeat	264..291	CDD:293787
		Uup	572..1122	CDD:223562	191/637 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810