DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9330 and GCN20

DIOPT Version :9

Sequence 1:	NP_649129.1	Gene:	CG9330 / 40131	FlyBaseID:	FBgn0036888	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_116664.1	Gene:	GCN20 / 850561	SGDID:	S000001905	Length:	752	Species:	Saccharomyces cerevisiae

Alignment Length:	785	Identity:	323/785 - (41%)
Similarity:	459/785 - (58%)	Gaps:	119/785 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEYTSILQREFPKIDHELLTYVVGV---LTGSEEDFESGDDI-----FEAVGDILQSVDCDRSE 57
            |:...|.:::....||..:..|.||.   |:|...|......:     .:.|.|:|  :|...|:
Yeast     1 MASIGSQVRKAASSIDPIVTDYAVGYFNHLSGITFDAVQSKQVDLSTEVQFVSDLL--IDAGASK 63

  Fly    58 ESVRTLCEQFL---------------------------NIMKN----NEVNVERKVLNAPVNIEE 91
            ..|:.|.|..|                           |::|:    :::||...:|....:||.
Yeast    64 AKVKELSESILKQLTTQLKENEAKLELTGDTSKRLLDINVLKSHNSKSDINVSLSMLGVNGDIEH 128

  Fly    92 MAKNMERLDKDMQSIWVANKDGANKVDSKKLGKAEAKLQQKQEKRQEVNKHGMIPVAVKLQTATA 156
            ..:.||                 .:||.|||.|||.|:.:|..||.  ||.      ||.:   |
Yeast   129 TGRKME-----------------TRVDLKKLAKAEQKIAKKVAKRN--NKF------VKYE---A 165

  Fly   157 SQVTNKKNTKLDQK------------------GLNRSMDIKIENFDLAFGE-KVLLQNANLLLSY 202
            |::.|      |||                  ...:|.||.|:.|||..|: :.:|.||.|.||:
Yeast   166 SKLIN------DQKEEDYDSFFLQINPLEFGSSAGKSKDIHIDTFDLYVGDGQRILSNAQLTLSF 224

  Fly   203 GRRYGLVGRNGLGKTTLLRMIAERQLQIPSHISVLHVEQEVVGDDTPAVESVLECDTERTRLLTR 267
            |.||||||:||:||:||||.::.|:|.:|.|:|:||||||:.||||.|::|||:.|..|.:||:.
Yeast   225 GHRYGLVGQNGIGKSTLLRALSRRELNVPKHVSILHVEQELRGDDTKALQSVLDADVWRKQLLSE 289

  Fly   268 EKEI--------------------LAALNNGVQDATLSNELSETYASLQNIEADKAVARASVILK 312
            |.:|                    :..|:|..:|  |.|.|.:....|.::|:|||.|||:.||.
Yeast   290 EAKINERLKEMDVLRQEFEEDSLEVKKLDNERED--LDNHLIQISDKLVDMESDKAEARAASILY 352

  Fly   313 GLGFDADMQLRPTKSFSGGWRMRLALARALFSKPDLLLLDEPTNMLDIKAIIWLENYLQTWATTI 377
            ||||..:.|.:||.||||||||||:||||||.:|||||||||:||||:.:|.:|..||:|:..|:
Yeast   353 GLGFSTEAQQQPTNSFSGGWRMRLSLARALFCQPDLLLLDEPSNMLDVPSIAYLAEYLKTYPNTV 417

  Fly   378 LVVSHDRNFLDTVPTDIIHLHSQELEAYKG-NYEQFEKTKTEKLKSQRREYEAQMAHRAHVQDFI 441
            |.|||||.||:.|.||||:.|::.|:.|:| :::.|..||.|:.|:.:|||:.||.:|.|:|:||
Yeast   418 LTVSHDRAFLNEVATDIIYQHNERLDYYRGQDFDTFYTTKEERRKNAQREYDNQMVYRKHLQEFI 482

  Fly   442 DRFRYNANRASSVQSKIKMLEKLPELKPVEKETVVTLKFPEVEPLNPPVLAISEVTFRYNPEDPL 506
            |::||||.::...||:||.|||||.|:|.|::..:..||||.:.|:||::.:.:|:|.|:..:.|
Yeast   483 DKYRYNAAKSQEAQSRIKKLEKLPVLEPPEQDKTIDFKFPECDKLSPPIIQLQDVSFGYDENNLL 547

  Fly   507 PIFKGVNLSATSDSRICIVGENGAGKSTLLKIIVGQLSTIHGNIVLHRGLRIGYFAQHHVDHLNM 571
              .|.|||....||||.:||.||.||:|||||::.||..:.|.:..:..||||||.|||||.:::
Yeast   548 --LKDVNLDVQMDSRIALVGANGCGKTTLLKIMMEQLRPLKGFVSRNPRLRIGYFTQHHVDSMDL 610

  Fly   572 NVTCVGVLAELFPGRPDEEYRRQLGSFGISGPLALQSIASLSGGQKSRVALAKMCMAEPNFLVLD 636
            ..:.|..:::.|||:.||||||.||||||:|.|.||.:..||||||||||.|.:|:..|:.||||
Yeast   611 TTSAVDWMSKSFPGKTDEEYRRHLGSFGITGTLGLQKMQLLSGGQKSRVAFAALCLNNPHILVLD 675

  Fly   637 EPTNHLDIETIDALGRAINAFKGGVILVSHDERLIKVVCKELWVCGNRTVRAIEGGLDEYKREVY 701
            ||:||||...:|||..|:..|.|||::||||..:|..||||:||....||:..||.:.:|:..:.
Yeast   676 EPSNHLDTTGLDALVEALKNFNGGVLMVSHDISVIDSVCKEIWVSEQGTVKRFEGTIYDYRDYIL 740

  Fly   702 KEIEA 706
            :..:|
Yeast   741 QSADA 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9330	NP_649129.1	PLN03073	1..698	CDD:215558	322/775 (42%)
		ABCF_EF-3	178..401	CDD:213188	124/243 (51%)
		ABC_tran_Xtn	395..480	CDD:289608	37/85 (44%)
		ABCF_EF-3	491..685	CDD:213188	99/193 (51%)
GCN20	NP_116664.1	PLN03073	<190..742	CDD:215558	272/555 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345871
Domainoid	1	1.000	176	1.000	Domainoid score	I735
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22784
Inparanoid	1	1.050	542	1.000	Inparanoid score	I174
Isobase	1	0.950	-	0	Normalized mean entropy	S692
OMA	1	1.010	-	-		QHG53504
OrthoFinder	1	1.000	-	-		FOG0000863
OrthoInspector	1	1.000	-	-		oto100186
orthoMCL	1	0.900	-	-		OOG6_100624
Panther	1	1.100	-	-	LDO	PTHR19211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1720
SonicParanoid	1	1.000	-	-		X3793
TreeFam	1	0.960	-	-
	16	15.740