DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9330 and ABCF3

DIOPT Version :9

Sequence 1:	NP_649129.1	Gene:	CG9330 / 40131	FlyBaseID:	FBgn0036888	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_060828.2	Gene:	ABCF3 / 55324	HGNCID:	72	Length:	709	Species:	Homo sapiens

Alignment Length:	711	Identity:	400/711 - (56%)
Similarity:	539/711 - (75%)	Gaps:	29/711 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEYTSILQREFPKIDHELLTYVVGVLTGSEEDFESGDDIFEAVGDILQSVDCDRSEES-VRTLC 64
            |:....||:.|||:||.::..||.|||.....||||.||:.||||::||.|..|..::: :|.:|
Human     1 MATCAEILRSEFPEIDGQVFDYVTGVLHSGSADFESVDDLVEAVGELLQEVSGDSKDDAGIRAVC 65

  Fly    65 EQFLNIMK--------NNEVNVERKVLNAPVNIEEMAKNMERLDKDMQSIWVANKDGANKVDSKK 121
            ::..|.::        |::|     :|:||:   :::|..|..|...:...:..::.::.|::||
Human    66 QRMYNTLRLAEPQSQGNSQV-----LLDAPI---QLSKITENYDCGTKLPGLLKREQSSTVNAKK 122

  Fly   122 LGKAEAKLQQKQEKRQEVN----KHGMIPVAVKLQTATASQVTNKKNTKLDQKGLNRSMDIKIEN 182
            |.||||:|:.|||||.|.:    .:.::     |:.|:|||..::|.::|:..|.|:|.|::|||
Human   123 LEKAEARLKAKQEKRSEKDTLKTSNPLV-----LEEASASQAGSRKESRLESSGKNKSYDVRIEN 182

  Fly   183 FDLAFGEKVLLQNANLLLSYGRRYGLVGRNGLGKTTLLRMIAERQLQIPSHISVLHVEQEVVGDD 247
            ||::||::|||..|::.|::||||||||||||||||||:|:|.|.|::|:|||:|||||||.|||
Human   183 FDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDD 247

  Fly   248 TPAVESVLECDTERTRLLTREKEILAALNNGVQDATLSNELSETYASLQNIEADKAVARASVILK 312
            |||::||||.|:.|..||.||:|:.|.:..|..:.:.:.||:|.||.|:.||||||.|||||||.
Human   248 TPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILA 312

  Fly   313 GLGFDADMQLRPTKSFSGGWRMRLALARALFSKPDLLLLDEPTNMLDIKAIIWLENYLQTWATTI 377
            ||||...||.:||:.||||||||||||||||::||||||||||||||::||:|||||||||.:||
Human   313 GLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTI 377

  Fly   378 LVVSHDRNFLDTVPTDIIHLHSQELEAYKGNYEQFEKTKTEKLKSQRREYEAQMAHRAHVQDFID 442
            ||||||||||:.:.|||||||||.|:.|:|::|.|.|:|.|:|.:|:||||||..:|.|:|.|||
Human   378 LVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQREYEAQQQYRQHIQVFID 442

  Fly   443 RFRYNANRASSVQSKIKMLEKLPELKPVEKETVVTLKFPE-VEPLNPPVLAISEVTFRYNPEDPL 506
            ||||||||||.||||:||||||||||||:||:.|.:|||: .|..:||:|.:.||.|.|:|:.
Human   443 RFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKH-- 505

  Fly   507 PIFKGVNLSATSDSRICIVGENGAGKSTLLKIIVGQLSTIHGNIVLHRGLRIGYFAQHHVDHLNM 571
            .||..:::||..:||||:||||||||||:||:::|.|:.:.|....||.|:||||:||||:.|::
Human   506 VIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDL 570

  Fly   572 NVTCVGVLAELFPGRPDEEYRRQLGSFGISGPLALQSIASLSGGQKSRVALAKMCMAEPNFLVLD 636
            ||:.|.:||..|||||:||||.|||.:||||.||::.:||||||||||||.|:|.|..|||.:||
Human   571 NVSAVELLARKFPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILD 635

  Fly   637 EPTNHLDIETIDALGRAINAFKGGVILVSHDERLIKVVCKELWVCGNRTVRAIEGGLDEYK 697
            |||||||:|||:|||||:|.|:|||||||||||.|::||:|||||....|..:|||.|:|:
Human   636 EPTNHLDMETIEALGRALNNFRGGVILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYR 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9330	NP_649129.1	PLN03073	1..698	CDD:215558	400/711 (56%)
		ABCF_EF-3	178..401	CDD:213188	152/222 (68%)
		ABC_tran_Xtn	395..480	CDD:289608	57/84 (68%)
		ABCF_EF-3	491..685	CDD:213188	120/193 (62%)
ABCF3	NP_060828.2	SunT	6..700	CDD:331423	399/706 (57%)
ABCF3	NP_060828.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..171		14/46 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158303
Domainoid	1	1.000	215	1.000	Domainoid score	I2722
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22784
Inparanoid	1	1.050	788	1.000	Inparanoid score	I522
Isobase	1	0.950	-	0	Normalized mean entropy	S692
OMA	1	1.010	-	-		QHG53504
OrthoDB	1	1.010	-	-		D249617at33208
OrthoFinder	1	1.000	-	-		FOG0000863
OrthoInspector	1	1.000	-	-		oto91332
orthoMCL	1	0.900	-	-		OOG6_100624
Panther	1	1.100	-	-	LDO	PTHR19211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1720
SonicParanoid	1	1.000	-	-		X3793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750