DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9330 and ABCF1

DIOPT Version :9

Sequence 1:	NP_649129.1	Gene:	CG9330 / 40131	FlyBaseID:	FBgn0036888	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_001020262.1	Gene:	ABCF1 / 23	HGNCID:	70	Length:	845	Species:	Homo sapiens

Alignment Length:	662	Identity:	277/662 - (41%)
Similarity:	382/662 - (57%)	Gaps:	50/662 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 MKNNEVNVERKVL---NAPVNIEEMAKNMER-LDKDMQSIWVANKDGANKVD------SKKLGKA 125
            :.|.|.:.|.:::   ..|...:|.||..|: .:::.:......:.|.:|.|      |||..|
Human   196 LDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKK- 259

  Fly   126 EAKLQQKQEKRQEVNKHGMIPVAVKLQTATASQ---VTNKKNTKLDQKGLNRSMDIKIENFDLAF 187
              ||:::.|..::|         ..|:.|.|::   ..::......|..|..:.|||:|.|.::.
Human   260 --KLKKQMEYERQV---------ASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISA 313

  Fly   188 GEKVLLQNANLLLSYGRRYGLVGRNGLGKTTLLRMIAERQLQIPSHISVLHVEQEVVGDDTPAVE 252
            ..|.|..||:|.:..||||||||.||.||||||:.||.|.|.||.:|.||..|||||.|:||||:
Human   314 HGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQ 378

  Fly   253 SVLECDTERTRLLTREKEILAALNNGVQDATLSNELSETYASLQNIEADKAVARASVILKGLGFD 317
            :||..||:|.:||..|:.:...|..|  |.|.:..|.:.|..|:...|..|.|:|..||.|||||
Human   379 AVLRADTKRLKLLEEERRLQGQLEQG--DDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFD 441

  Fly   318 ADMQLRPTKSFSGGWRMRLALARALFSKPDLLLLDEPTNMLDIKAIIWLENYLQTWATTILVVSH 382
            .:||.|||:.||||||||::||||||.:|.||:||||||.||:.|:|||.||||.|..|:|:|||
Human   442 PEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSH 506

  Fly   383 DRNFLDTVPTDIIHLHSQELEAYKGNYEQFEKTKTEKLKSQRREYEAQ---------------MA 432
            |:.|||.|.||||||.:|.|..|:|||..|:|...:|.|...::||.|               .|
Human   507 DQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQA 571

  Fly   433 HRAHVQDFIDRFRYNANRASSVQSKIKMLEKLPELKPVEKETVVTLKFPEVEPLNPPVLAISEVT 497
            .: ..::.:.|.:....|.:..:..    ::.|||....||..|...||:..||:||||.:..||
Human   572 EK-QTKEALTRKQQKCRRKNQDEES----QEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVT 631

  Fly   498 FRYNPEDPLPIFKGVNLSATSDSRICIVGENGAGKSTLLKIIVGQLSTIHGNIVLHRGLRIGYFA 562
            |.|..:.||  ||.::.....||||||||.||.||||||.::.|:|:..||.:..:..|:||:|.
Human   632 FGYQGQKPL--FKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFN 694

  Fly   563 QHHVDHLNMNVTCVGVLAELFPGRPDEEYRRQLGSFGISGPLALQSIASLSGGQKSRVALAKMCM 627
            |.:.:.|.|..|....|...| ..|.::.|:.||.||:........|..||||||:||..|::..
Human   695 QQYAEQLRMEETPTEYLQRGF-NLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELAC 758

  Fly   628 AEPNFLVLDEPTNHLDIETIDALGRAINAFKGGVILVSHDERLIKVVCKELWVCGNRTVRAIEGG 692
            .||:.|:||||||:||||:|||||.|||.:||.||:||||.|||.....:|||...::|..|:|.
Human   759 REPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGD 823

  Fly   693 LDEYKREVYKEI 704
            .::|||||.:.:
Human   824 FEDYKREVLEAL 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9330	NP_649129.1	PLN03073	1..698	CDD:215558	273/654 (42%)
		ABCF_EF-3	178..401	CDD:213188	125/222 (56%)
		ABC_tran_Xtn	395..480	CDD:289608	25/99 (25%)
		ABCF_EF-3	491..685	CDD:213188	90/193 (47%)
ABCF1	NP_001020262.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..261		15/67 (22%)
		Uup	302..833	CDD:223562	253/540 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..602		5/47 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53504
OrthoDB	1	1.010	-	-		D249617at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830