DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shal and KCNB2

DIOPT Version :9

Sequence 1:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster
Sequence 2:NP_004761.2 Gene:KCNB2 / 9312 HGNCID:6232 Length:911 Species:Homo sapiens


Alignment Length:550 Identity:189/550 - (34%)
Similarity:296/550 - (53%) Gaps:66/550 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ATHPLPPPPMPKDRRKTDDEKLLINVSGRRFET-WRNTLEKYPDTLLGS----NEREFF------ 75
            :|..|||.|:...|.||...::.|||.|...|. || ||::.|.|.||.    |..|..      
Human    16 STLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWR-TLDRLPRTRLGKLRDCNTHESLLEVCDD 79

  Fly    76 YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDR 140
            |:.:..||||||.|..|..|||:|||||||..:..|..|:.:||.::||....:..||...|..:
Human    80 YNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQK 144

  Fly   141 KRENAERL------MDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSV 199
            |.:..|.|      |.::..|..|...  ..:.|:|:|...|.|::|.:|.:...|:..||.:|.
Human   145 KEQMNEELRREAETMREREGEEFDNTC--CPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLST 207

  Fly   200 MANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSI 264
            :|..:.|:|........|.|....:...|    :..|:..||.|||||..::|::.||.:..:::
Human   208 IALSLNTLPELQETDEFGQLNDNRQLAHV----EAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNV 268

  Fly   265 IDVVAIMPYYIGLGITDND-------DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
            ||::||:|||:.:.:|:::       :|.......|:.|:.||.|.:|||.||:.||:||:...:
Human   269 IDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYN 333

  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387
            |||.|:..|||.|:||::::|:|||:.:.|.||||||:||:..:||||:||||:.|:|:.|||||
Human   334 ELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVG 398

  Fly   388 GVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADK----RKAQRKAR-------------LAR--- 432
            |:|.::||||||||:|:||:|||..|.:.:|.:|    |:|..:|:             .||   
Human   399 GLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSME 463

  Fly   433 -IRIAKASSGAAFVSKKKA-----AEARW-----AAQESGIELDDNYRDEDIFELQHHHLLRCLE 486
             |.:|...:|.:..:|..|     :.:||     |..|:........:.:::.:...|..|....
Human   464 LIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTS 528

  Fly   487 KTTDREF--VELEIPFNGQPK-RPGS-PSP 512
            .::.:..  .:||:.:|...| :|.| |:|
Human   529 SSSPQHLSAQKLEMLYNEITKTQPHSHPNP 558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 52/132 (39%)
Ion_trans 188..415 CDD:395416 99/233 (42%)
DUF3399 445..540 CDD:403174 15/81 (19%)
KCNB2NP_004761.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 2/5 (40%)
BTB 37..143 CDD:197585 43/106 (41%)
BTB_2 37..136 CDD:280393 40/99 (40%)
Ion_trans 230..428 CDD:278921 90/201 (45%)
Ion_trans_2 341..422 CDD:285168 49/80 (61%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 381..386 3/4 (75%)
Kv2channel 471..759 CDD:281514 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..534 2/30 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 549..571 4/9 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..665
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..739
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 760..865
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 892..911
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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