DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and KCNG4

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_758857.1	Gene:	KCNG4 / 93107	HGNCID:	19697	Length:	519	Species:	Homo sapiens

Alignment Length:	486	Identity:	151/486 - (31%)
Similarity:	240/486 - (49%)	Gaps:	62/486 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 WVPIATHPLPPPPM-----------------PKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDT 65
            |..:.:.|:..|.:                 |.|.:|    ::||||.|||:....:||:::|.:
Human    23 WSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKK----EILINVGGRRYLLPWSTLDRFPLS 83

  Fly    66 LLGS-----NEREFF-----YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELA 120
            .|..     :..|..     ||||.:|:||||.|..|..|:::...|||...:..|..|:.||||
Human    84 RLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELA 148

  Fly   121 FFGIMPDVIGDCCYEDYRDRKRENAERL----MDDKLSENGDQNLQQLTNMR-----QKMWRAFE 176
            ::||....:..||..... ||.|..|.|    .:|.|.:..:.......:.|     .::....|
Human   149 YWGIEEAHLERCCLRKLL-RKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREMVE 212

  Fly   177 NPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFT 241
            ||.:.....||..::..|:|.:.::..|.|:|........|  .|..:...:|. ::|.||..|:
Human   213 NPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQG--ECSRKCYYIFI-VETICVAWFS 274

  Fly   242 AEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGIT-----DNDDVSGAF------VTLRVF 295
            .|:.||...|.|:|:|.:..::|||::||.|||:.|.::     |.:..||:.      :.|||.
Human   275 LEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVL 339

  Fly   296 RVFRI---FKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGT-NFTS 356
            |..||   .:.:|||.||:.||.|::.|..|.|.|:..||:||.:|:.:::.|||..... .|||
Human   340 RALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTS 404

  Fly   357 IPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADK 421
            |||::|:.|::|||:|||||||.::.|::|.....|||:|::|.|...|...||   |......|
Human   405 IPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFS---HSYLELKK 466

  Fly   422 RKAQRKARLARIRIAKASSGAAFVSKKKAAE 452
            .:.|.:|||..::....:|....:....|:|
Human   467 EQEQLQARLRHLQNTGPASECELLDPHVASE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	45/152 (30%)
		Ion_trans	188..415	CDD:395416	86/241 (36%)
		DUF3399	445..540	CDD:403174	2/8 (25%)
KCNG4	NP_758857.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		1/1 (100%)
		BTB	61..161	CDD:197585	35/99 (35%)
		BTB_2	61..160	CDD:280393	35/98 (36%)
		Ion_trans	262..465	CDD:278921	80/206 (39%)
		Ion_trans_2	377..459	CDD:285168	37/84 (44%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	418..423		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810