DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and KCNQ4

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_004691.2	Gene:	KCNQ4 / 9132	HGNCID:	6298	Length:	695	Species:	Homo sapiens

Alignment Length:	367	Identity:	87/367 - (23%)
Similarity:	157/367 - (42%)	Gaps:	85/367 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 YYVTGFFIAVS-VMANVVETVPCGHRPGRAGTLPCGERYKIVFFC---LDTACVMIFTAEYLLRL 248
            |:|..|.:..| ::.:|:.|:.              |..::...|   |:...:::|..||::|:
Human   101 YHVFIFLLVFSCLVLSVLSTIQ--------------EHQELANECLLILEFVMIVVFGLEYIVRV 151

  Fly   249 FAA---------PDRCKFVRSVMSIIDVVAIMP--YYIGLGITDNDDVSGAFVTLRVFRVFRIFK 302
            ::|         ..|.:|.|....:||.:..:.  ..|..|...|...:.|..::|..::.|:.:
Human   152 WSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVR 216

  Fly   303 FSRHSQGLRILGYTLKSCASEL------GFLVFSLAMAIIIFATVMFY-AEKNVNGTNFTSIPAA 360
            ..|.....::||..:.:.:.||      ||||       :|||:.:.| |||:.| ::|:|...:
Human   217 MDRRGGTWKLLGSVVYAHSKELITAWYIGFLV-------LIFASFLVYLAEKDAN-SDFSSYADS 273

  Fly   361 FWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQ 425
            .|:..:|:||:||||..|.|..|:::....:|.|:...|||..::.|.|: :..|.|...|...:
Human   274 LWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFA-LKVQEQHRQKHFEK 337

  Fly   426 RKARLARI-----RIAKASSGAAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQHHHL---- 481
            |:...|.:     |:.......|:::      |.|...:|   :..::|:   ..|...|:
Human   338 RRMPAANLIQAAWRLYSTDMSRAYLT------ATWYYYDS---ILPSFRE---LALLFEHVQRAR 390

  Fly   482 ---LRCLEKTTDREFVELEIPFNGQPK---------RPGSPS 511
               ||.||..      ...:| :|.|.         ||||.|
Human   391 NGGLRPLEVR------RAPVP-DGAPSRYPPVATCHRPGSTS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:395416	62/248 (25%)
		DUF3399	445..540	CDD:403174	18/83 (22%)
KCNQ4	NP_004691.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		MIG-14_Wnt-bd	<92..190	CDD:284153	19/102 (19%)
		Ion_trans	126..330	CDD:278921	56/212 (26%)
		Ion_trans_2	246..320	CDD:285168	29/81 (36%)
		Selectivity filter. /evidence=ECO:0000250	283..288		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..480		8/33 (24%)
		KCNQ_channel	474..653	CDD:281513
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..515
		A-domain (Tetramerization)	546..650
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810