DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcnq1

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_114462.2	Gene:	Kcnq1 / 84020	RGDID:	621503	Length:	669	Species:	Rattus norvegicus

Alignment Length:	298	Identity:	78/298 - (26%)
Similarity:	134/298 - (44%)	Gaps:	49/298 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 TNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIV- 228
            |:::.:::...|.| |.....|:::.....:.|.::.:|:.|:               |:|..:
  Rat   104 THIQGRVYNFLERP-TGWKCFVYHFTVFLIVLVCLIFSVLSTI---------------EQYAALA 152

  Fly   229 ---FFCLDTACVMIFTAEYLLRLFAAPDRCKFV---------RSVMSIIDVVAIMPYYIGLGITD 281
               .|.::...|:.|..||::||::|..|.|:|         |..:||||::.::...:.|.:..
  Rat   153 TGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGS 217

  Fly   282 NDDV--SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLVFSLAMAIIIF 338
            ...|  :.|...:|..::.|:....|.....|:||..:.....||      |||.       :||
  Rat   218 KGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLG-------LIF 275

  Fly   339 ATVMFY-AEK---NVNG-TNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVI 398
            ::...| |||   |.:| ..|.|...|.|:.:||:||:||||.||:|..||.:....|:..:...
  Rat   276 SSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFF 340

  Fly   399 ALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIA 436
            |||..::.|.|:....|.||......|..|..:.|:.|
  Rat   341 ALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTA 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:395416	66/252 (26%)
		DUF3399	445..540	CDD:403174
Kcnq1	NP_114462.2	Ion_trans	123..359	CDD:395416	68/257 (26%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		Interaction with CALM. /evidence=ECO:0000250\|UniProtKB:P51787	370..382		3/9 (33%)
		KCNQ_channel	<511..617	CDD:397540
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000250\|UniProtKB:P51787	515..529
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000250\|UniProtKB:P51787	535..572
		Interaction with AKAP9. /evidence=ECO:0000250\|UniProtKB:P51787	588..616
		C-terminal assembly domain. /evidence=ECO:0000250\|UniProtKB:P51787	589..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810