DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcns3

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001376159.1	Gene:	Kcns3 / 83588	RGDID:	621527	Length:	491	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	144/417 - (34%)
Similarity:	232/417 - (55%)	Gaps:	49/417 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DDEKLLINVSGRRFETWRNTLEKYPDTLLGS-----NEREFF-----YDEDCKEYFFDRDPDIFR 93
            |:|.:.:||.|.:....::||.::|.|.||.     :|....     |....|||:|||:|.:||
  Rat    13 DEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFR 77

  Fly    94 HILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSE-NG 157
            ::||:|.|||||..:..|:.|:.:|:.::||....|..||...|::||.|:.|:..|.|.:: :.
  Rat    78 YVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSSRYQERKEESHEKDWDQKSNDVST 142

  Fly   158 DQNLQQLT---------------NMRQKMWRAFENPHTSTSALVFYYVTGFFIAVS----VMANV 203
            |.:.::.:               .:|:|:|...|||        .|.::...||:|    |:|::
  Rat   143 DSSFEESSLFEKELEKFDELRFGQLRKKIWIRMENP--------AYCLSAKLIAISSLSVVLASI 199

  Fly   204 VETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVV 268
            |  ..|.|....... ..||....|...::.||:..||.|..:||.|||.:.||.::.::|||.|
  Rat   200 V--AMCVHSMSEFQN-EDGEVDDPVLEGVEIACIAWFTGELAIRLVAAPSQKKFWKNPLNIIDFV 261

  Fly   269 AIMPYYIGLGITDNDDVS------GAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 326
            :|:|:|..|.:...::.|      |..| .||:.|:|||.|.:|||.|||.||.||:....|:|.
  Rat   262 SIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGL 326

  Fly   327 LVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCS 391
            |:..|::.|.||:.:::..||:...::.||||..:|:..::|||:||||..|.|:||||:...|.
  Rat   327 LLLFLSVGISIFSVLIYSVEKDELASSLTSIPICWWWATISMTTVGYGDTHPVTLAGKIIASTCI 391

  Fly   392 LSGVLVIALPVPVIVSNFSRIYHQNQR 418
            :.|:||:|||:.:|.:.||: |:|.|:
  Rat   392 ICGILVVALPITIIFNKFSK-YYQKQK 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	41/114 (36%)
		Ion_trans	188..415	CDD:395416	90/237 (38%)
		DUF3399	445..540	CDD:403174
Kcns3	NP_001376159.1	BTB_POZ_KCNS3	15..122	CDD:349735	37/106 (35%)
		Ion_trans	184..417	CDD:395416	90/236 (38%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810