DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnc4

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001182125.1	Gene:	kcnc4 / 799410	ZFINID:	ZDB-GENE-060503-773	Length:	603	Species:	Danio rerio

Alignment Length:	447	Identity:	164/447 - (36%)
Similarity:	245/447 - (54%)	Gaps:	66/447 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RKTDDEKLLINVSGRRFETWRNTLEKYPDT---LLGSNEREFFYDEDC------KEYFFDRDPDI 91
            |..|.:|::|||.|.|.||:|:||...|.:   .|...:.:...|.|.      .|:||||.|.|
Zfish    31 RCEDSDKIIINVGGTRHETYRSTLRTIPGSRLAWLADTDSQVNPDADTGQTHPNSEFFFDRHPGI 95

  Fly    92 FRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMD-----D 151
            |.::||||||||||.|...|...::|||||:||....:..||:..||..:  :||..:|     |
Zfish    96 FAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR--DAEEALDIFEPPD 158

  Fly   152 KLSENGDQNLQQLTNM--------------RQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMAN 202
            ......||::.:...:              :.|:|..||:|::|.:|.|..:|:.|||.||:...
Zfish   159 PEDAEDDQDMPRRFGIEDSPDRSRGCCEVWQPKIWALFEDPYSSRAARVIAFVSLFFILVSITNF 223

  Fly   203 VVETVPC-----GHRPGRAGTLPCGERYKIVFFCLDT---------ACVMIFTAEYLLRLFAAPD 253
            .:||...     .|...::.|     ....:...:||         .||:.||.|:|:|:...|:
Zfish   224 CLETHEAFFEFHNHTDTKSAT-----NSTTIIQVMDTKPVLTVVEGICVVWFTFEFLVRIICCPN 283

  Fly   254 RCKFVRSVMSIIDVVAIMPYYIGLGITDN-----DDVSGAFVTLRVFRVFRIFKFSRHSQGLRIL 313
            :..|:::.::|||.|||:|:|:...:..|     .||.|....:|..|:.||||.:||..|||:|
Zfish   284 KLLFIKNQLNIIDFVAILPFYLERSLIGNTSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVL 348

  Fly   314 GYTLKSCASELGFLVFSLAMAIIIFATVMFYAEK---------NVNGTNFTSIPAAFWYTIVTMT 369
            |:||::..:|...|:..||:.::||||:::|||:         ..|.|:|.:||..||:.:||||
Zfish   349 GHTLRASVNEFCLLIIFLALGVLIFATMIYYAERISADPDDPSGCNHTHFKNIPIGFWWAVVTMT 413

  Fly   370 TLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRK 423
            |||||||||:|..|.|||.:|:::|||.||:||||||:||...|.   ..|:..|:|
Zfish   414 TLGYGDMVPKTWLGMIVGALCAIAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	48/116 (41%)
		Ion_trans	188..415	CDD:395416	99/257 (39%)
		DUF3399	445..540	CDD:403174
kcnc4	NP_001182125.1	amino terminal assembly domain	1..206		60/176 (34%)
		Potassium_chann	1..29	CDD:288290
		BTB	38..144	CDD:197585	45/105 (43%)
		BTB_2	38..136	CDD:280393	41/97 (42%)
		S1-S6 membrane domain	207..516		103/269 (38%)
		Ion_trans	248..461	CDD:278921	89/212 (42%)
		Ion_trans_2	365..451	CDD:285168	45/85 (53%)
		post S6 proximal carboxyl terminal domain	517..581
		distal carboxyl terminus	582..603
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810