DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnq1.2

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_017209602.2	Gene:	kcnq1.2 / 796289	ZFINID:	ZDB-GENE-130530-935	Length:	597	Species:	Danio rerio

Alignment Length:	280	Identity:	72/280 - (25%)
Similarity:	127/280 - (45%)	Gaps:	49/280 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 TNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIV- 228
            |:|:..::...|.| ......:::::....:.|.::.:|:.|:               |:|...
Zfish   114 TSMQGDVYNFLERP-AGLRCFLYHFLVFLMVLVCLIFSVLSTI---------------EQYADFA 162

  Fly   229 ---FFCLDTACVMIFTAEYLLRLFAA---------PDRCKFVRSVMSIIDVVAIMPYYIGLGITD 281
               .|.::...|:.|..||::||::|         ..|.:|:|..:||||::.::...:.|.:..
Zfish   163 TGSLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIKGRLRFIRKPISIIDLIVVVASVVVLSVGS 227

  Fly   282 NDDV--SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLVFSLAMAIIIF 338
            |..|  :.|...:|..::.|:....|.....|:||..:.....||      |||.       :||
Zfish   228 NGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLG-------LIF 285

  Fly   339 ATVMFY-AEKNV----NGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVI 398
            ::...| |||:.    ..|.|:|...|.|:.:||:||:||||.||:|..||.:....|:..:...
Zfish   286 SSYFVYLAEKDAVDEEGKTGFSSYADALWWGVVTVTTIGYGDKVPQTWIGKAIASCFSVFAISFF 350

  Fly   399 ALPVPVIVSNFSRIYHQNQR 418
            |||..::.|.|:....|.||
Zfish   351 ALPAGILGSGFALKVQQKQR 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:395416	65/252 (26%)
		DUF3399	445..540	CDD:403174
kcnq1.2	XP_017209602.2	Ion_trans	133..369	CDD:306908	66/257 (26%)
kcnq1.2	XP_017209602.2	KCNQ_channel	487..>597	CDD:308886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910