DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and si:ch73-334d15.4

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_001336524.4	Gene:	si:ch73-334d15.4 / 796217	ZFINID:	ZDB-GENE-091204-184	Length:	430	Species:	Danio rerio

Alignment Length:	423	Identity:	134/423 - (31%)
Similarity:	220/423 - (52%)	Gaps:	57/423 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDC-KEYFFDRDPDIFRHILNYYRTGKL 104
            ||:::||.|.:.||.|.||...|    ||...|....|.. .|.||||.|::|.|:|.|||:|||
Zfish    17 EKIVLNVGGVKHETLRTTLMSLP----GSRLAELVNTEKSPSELFFDRHPEVFAHVLQYYRSGKL 77

  Fly   105 HYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLS------ENGDQNLQQ 163
            |.|.:.|....:||..|:||....:..||:|.::..| |..:.|...|.|      |:|.:  ||
Zfish    78 HCPSNLCGLLLEEEFTFWGISSADVEPCCWETFQQNK-ETLKALAGIKPSVMKKEEESGQK--QQ 139

  Fly   164 LTNMR---QKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPC--GH------------ 211
            .::.|   :|:|..|:.|::|..|.:...::.|||.:|::|..:.|:|.  .|
Zfish   140 SSSSRGWQRKIWALFDKPYSSVCARIIAIISLFFILLSIIAFSLWTLPSINSHQFLNAWASNSTD 204

  Fly   212 -----RPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIM 271
                 ||..|..|.          .::..|.:.|..|:.:|..:.|.:..|..:||:|:|::|:.
Zfish   205 DFSRTRPPEAQALD----------AVEIVCSIWFVFEFAIRAGSCPSKLWFFINVMNIVDLLALF 259

  Fly   272 PYYIGLGITDNDDV--SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMA 334
            |::.... ::|..|  .|....:|..|:.|:||..:|..|:|:|.:||::..:.|..:...|::.
Zfish   260 PWFFRWS-SNNFSVFALGFLHAMRCIRLLRVFKLMQHVFGVRVLTHTLRASLTSLCIVPLLLSIC 323

  Fly   335 IIIFATVMFYAEKNVNGTNFTSIPA--AFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLV 397
            .:||.|:.::||.....:..:|...  .||:.:||:||:|||||:|.|..||.|..:|::.|||:
Zfish   324 TLIFGTMFYFAELTHKDSYISSSSGLDGFWWALVTLTTVGYGDMLPVTRQGKCVAFLCAMVGVLL 388

  Fly   398 IALPVPVIVSNFSRI------YHQNQRADKRKA 424
            |.||||:||:||.:.      .|...|.:::::
Zfish   389 IVLPVPIIVNNFLKFSSLVKTKHSMPRMNEKRS 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	42/103 (41%)
		Ion_trans	188..415	CDD:395416	75/255 (29%)
		DUF3399	445..540	CDD:403174
si:ch73-334d15.4	XP_001336524.4	BTB	19..107	CDD:197585	37/91 (41%)
		BTB_2	19..105	CDD:280393	36/89 (40%)
		Ion_trans	217..400	CDD:278921	62/193 (32%)
		Ion_trans_2	319..402	CDD:285168	36/82 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810