DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shal and kcna6a

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001124098.1	Gene:	kcna6a / 795490	ZFINID:	ZDB-GENE-080722-21	Length:	475	Species:	Danio rerio

Alignment Length:	429	Identity:	160/429 - (37%)
Similarity:	238/429 - (55%)	Gaps:	55/429 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EKLLINVSGRRFETWRNTLEKYPDTLLGSN-EREFFYDEDCKEYFFDRDPDIFRHILNYYRT-GK 103
            |.:.||:||.||||...||.:||:||||.. :|..|:|....|:||||:...|..||.||:: |:
Zfish    31 ELVTINISGLRFETQLKTLARYPNTLLGDPIKRMRFFDPLRNEFFFDRNRPSFDAILYYYQSGGR 95

  Fly   104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMR 168
            |..|.:..:..:.:|:.|:.|..|||                :...:|:.....|:........:
Zfish    96 LRRPINVPVDMFLDEIKFYEIGDDVI----------------KHFQEDEGLLKEDERPLPSNEFK 144

  Fly   169 QKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP---------CGHRPGRAGT-LPCGE 223
            :::|..||:|.:|.:|.:...|:...|.:|::...:||:|         ..|.|..:.| :....
Zfish   145 RQIWLLFEHPDSSGAARIIAIVSVMVILISIIIFCIETLPEFREDDRVFDNHLPANSTTSVQRLS 209

  Fly   224 RYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLG-----ITDND 283
            .|...||.|:|.|::.|..|..:|..|.|.:..|.:.:|:.||:||||||:|.|.     :..|.
Zfish   210 AYTDPFFLLETICIVWFCFELFIRFLACPSKPTFFKDIMNTIDIVAIMPYFITLSLELGEVQSNQ 274

  Fly   284 DVSGAFVTLRVF---RVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYA 345
            ..:.:...|||.   |||||||.||||:||:|||.||::...|||.|:|.|.:.||:|::.:::|
Zfish   275 QQTTSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLIIGIILFSSAVYFA 339

  Fly   346 EKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFS 410
            |.:...|:|||||.|||:.:|:|||:|||||.|.||.|||||.:|:::|||.||||||||||||:
Zfish   340 EADDPETSFTSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSMCAIAGVLTIALPVPVIVSNFN 404

  Fly   411 RIYHQN-------------------QRADKRKAQRKARL 430
            ..||:.                   .:.|:.|:..|:.|
Zfish   405 YFYHREHNEADQVEYTHVTCGRSLPMQCDRNKSDSKSSL 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	39/104 (38%)
		Ion_trans	188..415	CDD:395416	108/244 (44%)
		DUF3399	445..540	CDD:403174
kcna6a	NP_001124098.1	BTB	33..122	CDD:197585	38/104 (37%)
		BTB_2	33..121	CDD:280393	36/87 (41%)
		Ion_trans	211..411	CDD:278921	100/199 (50%)
		Ion_trans_2	<350..401	CDD:285168	35/50 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810