Protein Alignment Shal and Kcnd2

DIOPT Version :10

• Sequence 1: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_113918.2
• Gene: Kcnd2 / 65180
• RGDID: 68393
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 539
• Identity: 377/539 - (69%)
• Similarity: 440/539 - (81%)
• Gaps: 16/539 - (2%)

  Fly     2 ASVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTL 66
            |.|||||||||||||||:|:|:.|:|.||. ::|::|.|..:::||||.||:||::|||:|||||
  Rat     3 AGVAAWLPFARAAAIGWMPVASGPMPAPPR-QERKRTQDALIVLNVSGTRFQTWQDTLERYPDTL 66

  Fly    67 LGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGD 131
            |||:||:|||..:.::|||||||||||||||:|||||||||:|||:::|||||||||::|::|||
  Rat    67 LGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGD 131

  Fly   132 CCYEDYRDRKRENAERLMDDKLSEN-GDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFI 195
            ||||:|:||:|||||||.||..::| |:..|..:| .||::|||||||||||.||||||||||||
  Rat   132 CCYEEYKDRRRENAERLQDDADTDNTGESALPTMT-ARQRVWRAFENPHTSTMALVFYYVTGFFI 195

  Fly   196 AVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRS 260
            ||||:||||||||||..||....|||||||.:.|||||||||||||.||||||.|||.|.:||||
  Rat   196 AVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRS 260

  Fly   261 VMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 325
            ||||||||||:||||||.:|||:||||||||||||||||||||||||||||||||||||||||||
  Rat   261 VMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 325

  Fly   326 FLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVC 390
            ||:|||.|||||||||||||||..:.:.|||||||||||||||||||||||||:||||||.|.:|
  Rat   326 FLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390

  Fly   391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARW 455
            ||||||||||||||||||||||||||||||||:||:||||||||.||:.|..|::..|:......
  Rat   391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSN 455

  Fly   456 AAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFN------GQPKRPGSPSPMA 514
            ..|.|..|.....:....||.||||||.||||||:.|||:.:: |.      ....||.|.||
  Rat   456 QLQSSEDEPAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQV-FEESCMEVATVNRPSSHSP-- 517

  Fly   515 SPAHSTNSAAGLLQSCCGR 533
                |.:|..|:..:||.|
  Rat   518 ----SLSSQQGVTSTCCSR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	94/137 (69%)
		Ion_trans	188..415	CDD:459842	195/226 (86%)
		DUF3399	471..535	CDD:463381	29/69 (42%)
Kcnd2	NP_113918.2	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000305|PubMed:14980206, ECO:0000305|PubMed:14980207	2..20		15/16 (94%)
		BTB_POZ	6..144	CDD:453885	95/138 (69%)
		Interaction with KCNIP1. /evidence=ECO:0000305|PubMed:14980207	71..90		11/18 (61%)
		Ion_trans	184..415	CDD:459842	199/230 (87%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	308..321		12/12 (100%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)
		DUF3399	470..546	CDD:463381	29/70 (41%)
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000305|PubMed:16820361	474..630		29/66 (44%)
		Required for dendritic targeting. /evidence=ECO:0000269|PubMed:12592409	474..489		12/14 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..623
		PDZ-binding. /evidence=ECO:0000269|PubMed:11923279, ECO:0000269|PubMed:14559911	627..630