DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and Kcnq4

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001074611.1	Gene:	Kcnq4 / 60613	MGIID:	1926803	Length:	696	Species:	Mus musculus

Alignment Length:	400	Identity:	91/400 - (22%)
Similarity:	170/400 - (42%)	Gaps:	83/400 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 QLTNMRQKMWRAFEN--------PHTSTSALVFYYVTGFFIAV--SVMANVVETVPCGHRPGRAG 217
            |.::..||.:|..:|        |.    ...|.|....|:.|  .::.:|:.|:.
Mouse    72 QRSSAAQKRYRRLQNWVYNVLERPR----GWAFVYHVFIFLLVFSCLVLSVLSTIQ--------- 123

  Fly   218 TLPCGERYKIVFFC---LDTACVMIFTAEYLLRLFAA---------PDRCKFVRSVMSIIDVVAI 270
                 |..::...|   |:...:::|..||::|:::|         ..|.:|.|....:||.:..
Mouse   124 -----EHQELANECLLILEFVMIVVFGLEYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVF 183

  Fly   271 MP--YYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFL 327
            :.  ..|..|...|...:.|..::|..::.|:.:..|.....::||..:.:.:.||      |||
Mouse   184 VASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFL 248

  Fly   328 VFSLAMAIIIFATVMFY-AEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCS 391
            |       :|||:.:.| |||:.| ::|:|...:.|:..:|:||:||||..|.|..|:::....:
Mouse   249 V-------LIFASFLVYLAEKDAN-SDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFA 305

  Fly   392 LSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARI-----RIAKASSGAAFVSKKKAA 451
            |.|:...|||..::.|.|: :..|.|...|...:|:...|.:     |:....:..|:::
Mouse   306 LLGISFFALPAGILGSGFA-LKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDTSRAYLT----- 364

  Fly   452 EARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSPS--PMA 514
             |.|...:|   :..::|:   ..|...|    :::..:.....||:  ...|...|:||  |..
Mouse   365 -ATWYYYDS---ILPSFRE---LALLFEH----IQRARNGGLRPLEV--RRAPVPDGAPSRYPPV 416

  Fly   515 SPAHSTNSAA 524
            :..|...||:
Mouse   417 ATCHRPGSAS 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:395416	61/249 (24%)
		DUF3399	445..540	CDD:403174	16/81 (20%)
Kcnq4	NP_001074611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		MIG-14_Wnt-bd	<93..191	CDD:284153	20/115 (17%)
		Ion_trans	127..331	CDD:278921	56/212 (26%)
		Ion_trans_2	247..321	CDD:285168	29/81 (36%)
		Selectivity filter. /evidence=ECO:0000250	284..289		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..484
		KCNQ_channel	471..654	CDD:281513
		A-domain (Tetramerization). /evidence=ECO:0000250	546..650
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..609
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810