DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shal and kcnq5b

DIOPT Version :9

Sequence 1:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	XP_697081.4	Gene:	kcnq5b / 568646	ZFINID:	ZDB-GENE-090312-178	Length:	974	Species:	Danio rerio

Alignment Length:	313	Identity:	73/313 - (23%)
Similarity:	145/313 - (46%)	Gaps:	51/313 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 RDRKRENAE-RLMDDKL---SENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAV- 197
            |||.::.|. .|:...|   :::|.:| .:...::..::...|.|.    :..|.|....|:.|
Zfish    64 RDRGKQGARLSLLGKPLVYGTQSGRRN-ARYRRIQNYLYNVLERPR----SWAFIYHAFVFVLVF 123

  Fly   198 -SVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAA---------P 252
             .::.:|..|:| .|:...:.:|          ..|:...:::|..||::|:::|         .
Zfish   124 GCLVLSVFSTIP-DHQEMASQSL----------LILEFVMIVVFGLEYIIRIWSAGCCCRYRGWQ 177

  Fly   253 DRCKFVRSVMSIIDVVAIMP--YYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGY 315
            .|.:|.|....:||::.::.  ..:..|...|...:.|..:||..::.|:.:..|.....::||.
Zfish   178 GRLRFARKPFCVIDIIVLIASVAVVSAGSQSNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGS 242

  Fly   316 TLKSCASEL------GFLVFSLAMAIIIFATVMFY-AEKNVNGTNFTSIPAAFWYTIVTMTTLGY 373
            .:.:.:.||      ||||       :||::.:.| .||..| .:|.:...|.|:..:|:||:||
Zfish   243 VVYAHSKELVTAWYIGFLV-------LIFSSFLVYLVEKEFN-KDFATYADALWWGTITLTTIGY 299

  Fly   374 GDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFS---RIYHQNQRADKRK 423
            ||..|:|..|:::....:|.|:....||..::.|.|:   :..|:.:..:||:
Zfish   300 GDKTPKTWTGRMLSAGFALLGISFFTLPAGILGSGFALKVQEQHRQKHFEKRR 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	3/5 (60%)
		Ion_trans	188..415	CDD:395416	59/249 (24%)
		DUF3399	445..540	CDD:403174
kcnq5b	XP_697081.4	Ion_trans	145..343	CDD:278921	52/215 (24%)
		Ion_trans_2	259..333	CDD:285168	26/81 (32%)
		KCNQ_channel	443..625	CDD:281513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810